Abstract: The invention provides arylthioether acetamide and related compounds, pharmaceutical compositions, and their use in the treatment of medical conditions, such as bacterial infections, and in inhibiting LpxA activity.

Abstract: A hand-held device for picking fruit which includes an elongated grip member and a head member connected to the elongated grip member which includes a pair of fixed immovable blades. Each blade has a cutting edge. The blades are positioned in the head in opposed planar relationship to one another so that at least a portion of each respective cutting edge is in spaced opposed relationship to the cutting edge of the other blade at a distance less than the thickness of the stem of the fruit to be picked. Picking is accomplished by a thrusting motion in which the device is held in one of the laborers hands while the fruit to be picked is grasped in the other. The device is thrust at the stem of the fruit to be picked. The pair of fixed blades guides the stem into the cutting region where the stem is severed. The fruit can be removed by the hand holding it during the cutting operation.