Abstract: The disclosure provides at least one entity chosen from compounds of Formula I, a tautomer thereof, a deuterated derivative of that compound or tautomer, and a pharmaceutically acceptable salt of any of the foregoing, compositions comprising the same, and methods of using the same, including uses in treating APOL1-mediated diseases, including pancreatic cancer, focal segmental glomerulosclerosis (FSGS), and/or non-diabetic kidney disease (NDKD).

Abstract: A method for execution by a touch screen computing device includes obtaining a touch signal associated with a row electrode of a touch screen display that is operable to render frames of data into visible images, where the touch screen display includes rows of electrodes oriented with columns of electrodes. The method further includes spatial filtering the touch signal in a first direction of the row electrode with respect to columns of the electrodes that form intersections with the row electrode to produce first direction touch signal data. The method further includes spatial filtering the touch signal in a second direction of the row electrode with respect to the intersections to produce second direction touch signal data. The method further includes combining the first and second direction touch signal data to produce a filtered touch signal. The method further includes processing the filtered touch signal to determine touch data.

Abstract: A method for execution by a touch screen computing device includes obtaining a touch signal associated with a row electrode of a touch screen display that is operable to render frames of data into visible images, where the touch screen display includes rows of electrodes oriented with columns of electrodes. The method further includes spatial filtering the touch signal in a first direction of the row electrode with respect to columns of the electrodes that form intersections with the row electrode to produce first direction touch signal data. The method further includes spatial filtering the touch signal in a second direction of the row electrode with respect to the intersections to produce second direction touch signal data. The method further includes combining the first and second direction touch signal data to produce a filtered touch signal. The method further includes processing the filtered touch signal to determine touch data.

Abstract: A debris guard for installation on an eavestrough is disclosed. The debris guard including a frame with a back side, a front side, a length and two ends. The frame having a water collection portion between the front side and the back side that extends along the length of the frame, the water collection portion having a plurality of holes to allow rainwater to pass through. The frame having a connector engagement structure that extends outward from a surface of the water collection portion, the connector engagement structure being shaped and/or sized to attach with a connector for joining pieces or lengths of the frame together.

Abstract: Examples of hearing assistance devices are described. The hearing assistance devices include an enclosing structure configured to house a receiver that generates sound waves into an ear canal of a user when the hearing assistance device is worn, and a tube coupled to the receiver to direct the sound waves into the ear canal of the user. The tube may include magnetized particles that form a magnetic field through the tube. The tube may include a portion of hydrophilic coating and a portion of hydrophobic coating. The hearing assistance device may include a coiled wire configured to carry an alternating current to generate an electro-magnetic field through the tube.

Abstract: The disclosure is directed at a hanger bracket for use within an eavestrough system. The hanger bracket provides support to the eavestrough by transferring any weight experienced by the eavestrough to the structure to which the eavestrough is mounted.

Abstract: A modularized, electric pumping unit comprising: a base structure; an electric motor mounted on the base structure; and one or more pump modules. Each of the one or more pump modules comprises a pump and a pump module structure. The one or more pump modules are configured to be removably mounted on the base structure and driven by the electric motor.

Abstract: Computer-aided design of water treatment systems assesses very large numbers of variables and conditions to facilitate water treatment system recommendations. In an embodiment, field engineers or sales representatives at virtually any level of experience can take water samples and gather site data on a customer's site and input the sample data and the site data to a computing system, which may be a standalone portable device or may be a portable device connected via a network or the cloud to a central computing system.

Abstract: A rotary valve and float assembly for controlling a flow of liquid into a container including a plug valve portion and a divider portion. The plug valve portion including a set of plugs that seal against a set of openings in the divider portion when the rotary valve is in a closed position. Movement of the rotary valve between open and closed positions is controlled by the movement of the float assembly in the container. The float assembly typically moves according to a liquid level within the container.

Abstract: An acoustic core may include an array of resonant cells configured as a plurality of resonant cell groups. The resonant cell groups may include a plurality of resonant cells configured as a partitioned resonant cell that include a converging resonant cell and a diverging resonant cell. The converging resonant cell and the diverging resonant cell may be defined by a plurality of cell walls integrally formed with one another and a partition integrally formed with the plurality of cell walls. The partition may at least partially delimit the converging resonant cell from the diverging resonant cell. The converging resonant cell may define an upper resonant space delimited by the partition and a top face of the array of resonant cells. The diverging resonant cell may define a lower resonant space delimited by the partition and a bottom face of the array of resonant cells.

Abstract: A connector is provided to attach a supported member to a supporting member, with the supported member being in sloped and skewed relation to the supporting member. The connector has back members attached to side members. A seat member attaches to the side members through a hinged connection. The seat member interfaces with the bottom face of the supported member and can be disposed at a sloped angle. A pair of seat side members extend from the seat member.

Abstract: Compounds or their pharmaceutically acceptable salts can inhibit the G12D mutant of Kirsten rat sarcoma (KRAS) protein and are expected to have utility as therapeutic agents, for example, for treating cancer. The disclosure also provides pharmaceutical compositions which comprise compounds disclosed herein or pharmaceutically acceptable salts thereof. The disclosure also relates to methods for use of the compounds or their pharmaceutically acceptable salts in the therapy and prophylaxis of cancer and for preparing pharmaceuticals for this purpose.

Abstract: Examples of hearing assistance devices are described. The hearing assistance devices include an enclosing structure configured to house a receiver that generates sound waves into an ear canal of a user when the hearing assistance device is worn, and a tube coupled to the receiver to direct the sound waves into the ear canal of the user. The tube may include magnetized particles that form a magnetic field through the tube. The tube may include a portion of hydrophilic coating and a portion of hydrophobic coating. The hearing assistance device may include a coiled wire configured to carry an alternating current to generate an electro-magnetic field through the tube.

Abstract: A support for enabling cutting of a linear product, such as an eavestrough debris guard, is disclosed. The eavestrough debris guard has a top, two sides, a bottom, and a non-linear profile. The support includes a contoured top complementary to a bottom portion of the non-linear profile. The support includes a plurality of surfaces extending from the contoured top positioned to engage with the two sides of the linear product. The support includes a plurality of contoured portions each coupled to one of the surfaces positioned to engage with the top of the linear product. The support includes a gap passing through the contoured top and the plurality of surfaces shaped and dimensioned to allow passage of at least a portion of a cutting tool.

Abstract: A support for enabling cutting of a linear product, such as an eavestrough debris guard, is disclosed. The eavestrough debris guard has a top, two sides, a bottom, and a non-linear profile. The support includes a contoured top complementary to a bottom portion of the non-linear profile. The support includes a plurality of surfaces extending from the contoured top positioned to engage with the two sides of the linear product. The support includes a plurality of contoured portions each coupled to one of the surfaces positioned to engage with the top of the linear product. The support includes a gap passing through the contoured top and the plurality of surfaces shaped and dimensioned to allow passage of at least a portion of a cutting tool.

Abstract: A downspout diverter for diverting collected water, such as rainwater. The diverter either directs the collected water towards a storage tank, such as a rainwater harvesting storage tank to towards an outflow portion. When the collected water is directed towards the outflow portion, the water exits the diverter spilling the water to the ground.

Abstract: A rotary valve and float assembly for controlling a flow of liquid into a container including a plug valve portion and a divider portion. The plug valve portion including a set of plugs that seal against a set of openings in the divider portion when the rotary valve is in a closed position. Movement of the rotary valve between open and closed positions is controlled by the movement of the float assembly in the container. The float assembly typically moves according to a liquid level within the container.

Abstract: A support for enabling cutting of a linear product, such as an eavestrough debris guard, is disclosed. The eavestrough debris guard has a top, two sides, a bottom, and a non-linear profile. The support includes a contoured top complementary to a bottom portion of the non-linear profile. The support includes a plurality of surfaces extending from the contoured top positioned to engage with the two sides of the linear product. The support includes a plurality of contoured portions each coupled to one of the surfaces positioned to engage with the top of the linear product. The support includes a gap passing through the contoured top and the plurality of surfaces shaped and dimensioned to allow passage of at least a portion of a cutting tool.

Abstract: Methods, apparatus, and systems are disclosed that determine property recommendations for a user. The methods, apparatus, and systems may also predict when a user is likely to become a property buyer and/or seller to determine when certain property recommendations are to be made. The methods, apparatus, and systems use one or more machine learning algorithms to determine a dynamic preference profile for a user that accurately reflects the user and how the user changes over time. The preference profile takes into account property-related information and user characteristic information as variables for the machine learning algorithm(s).

Abstract: A debris guard for installation on an eavestrough is disclosed. The debris guard includes a frame having a back side, a front side, a length, two ends, a top surface, a bottom surface opposite the top surface, and a water collection portion extending from the front side to the back side and along the length of the frame between the two ends. The water collection portion includes a plurality of holes to allow rainwater to pass through. The water collection portion also includes a plurality of drip legs coupled to the plurality of holes, the plurality of drip legs extending below the bottom surface to provide improved water flow through the eavestrough debris guard. Each of the plurality of holes includes at least one drip leg that provide improved flow through the debris guard.