Abstract: In one aspect, the invention relates to a crystalline form of the structure: or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crystalline form; methods of using this crystalline form and its soluble form (I); and processes for preparing soluble (I) and crystalline (I?) forms.

Abstract: In some aspects, systems and methods for rapidly building, managing, and sharing machine learning models are provided. Managing the lifecycle of machine learning models can include: receiving a set of unannotated data; requesting annotations of samples of the unannotated data to produce an annotated set of data; building a machine learning model based on the annotated set of data; deploying the machine learning model to a client system, wherein production annotations are generated; collecting the generated production annotations and generating a new machine learning model incorporating the production annotations; and selecting one of the machine learning model built based on the annotated set of data or the new machine learning model.

Abstract: A system that synchronizes waveforms received over a network from one or more devices, such as medical devices. Because of network delays or losses, waveforms can arrive at varying rates and times. Precise post-synchronization of the received data, to within a few milliseconds, is needed for accurate analysis. Applications include automatic classification of waveforms, such as detection of myocardial infraction from heart monitor waveforms. Synchronization uses sequence numbers assigned by each device, but must also account for sequence number wraparounds. Waveforms may also be synchronized across devices, by calculating the bias between within-device synchronized times and a common time source or common disturbance. Waveform data may also be stored data in a database or data warehouse; embodiments may index the data using a key with a date-time prefix and a hash code suffix, to support distributed indexing while reducing the chance of hash collisions to a very small probability.

Abstract: A system for managing security within an enterprise includes a computing device that receives a vulnerability, generates a user score for each user within the enterprise and generates a threat score for the vulnerability. A user device score may also be generated for each device associated with a user. Based on the user score and the threat score, a composite score is generated. After acquiring a security measure, the security measure is implemented based on the composite score and, at times, the user score.

Abstract: The present invention relates to a nitrification inhibitor formulation for use in combination with anhydrous ammonia, comprising an inhibitor fraction, a solvent fraction and a co-solvent fraction, wherein the inhibitor fraction comprises at least one agriculturally-acceptable inhibitor compound selected from formula 1-6 or a salt thereof, the solvent fraction comprises a polar aprotic solvent, and the co-solvent fraction comprises an ethanolamine compound.

Abstract: A battery pack for an electric vehicle or a hybrid vehicle may include a housing, a stack of battery cells disposed within the housing, and a cooling subassembly. The housing typically holds the cell stack together, and the cooling subassembly typically cools the cell stack to prevent damage to the battery cells and to maintain the performance of the battery cells. The cooling subassembly may include a cold plate defining a liquid flow channel and one or more thermoelectric devices (TEDs) that are operable to cool the cell stack when current is supplied thereto. Heat spreaders may be employed within the battery pack, and exemplary configurations of components to thermally and mechanically couple the cooling subassembly are described.

Abstract: A solid compounded fertilizer in the form of discrete particles, the solid fertiliser having a biological release profile, the solid fertilizer comprising, in a single particle a torrefied organic waste comprising labile carbon and a binder. The torrefied organic material is bound by the binder into the single particle thereby the labile carbon of the organic material is readily available for metabolism by microbes following application of the compounded fertilizer composition to soil or growing media.

Abstract: Described herein is a method of preparing a thermoresponsive polymer biomacromolecule conjugate, the method comprising: preparing by living cationic ring opening polymerisation a thermoresponsive polymer selected from polyoxazoline, polyoxazine, or copolymer thereof, the so-formed thermoresponsive polymer having a living cation; and reacting the living cation with a nucleophilic functional group selected from carboxylate, amino, sulfate, sulfonate, phosphate, phosphonate and thiol of a biomacromolecule to conjugate the thermoresponsive polymer to the biomacromolecule; wherein in an aqueous liquid the so-formed thermoresponsive polymer biomacromolecule conjugate exhibits a gelation temperature and forms a hydrogel in that liquid above that gelation temperature.

Abstract: A method for manufacturing a dual conductor laminated substrate includes providing a first laminate including a first insulating layer and a first conductive layer; defining a first trace pattern including one or more traces in the first laminate; providing a second laminate including a second insulating layer and a second conductive layer; defining a second trace pattern including one or more traces in the second laminate; defining access holes in the second insulating layer; at least one of depositing and stenciling a conductive material in the access holes of the second insulating layer; and aligning and attaching the first laminate to the second laminate to create a laminated substrate.

Abstract: A dry and solid fertiliser in the form of discreet particles is provided. The particles of the dry and solid fertiliser comprise a homogenous mixture of organic and inorganic materials. The inorganic material comprises at least one of the NPKS nutrients. The organic material comprises a carbon-labile substantially sterile product of organic waste.

Abstract: A method for manufacturing a double-sided, single conductor laminate includes providing a laminated substrate that includes a conductive layer, an adhesive layer and a support layer; dry milling a trace pattern in the laminated substrate by removing selected areas of the conductive layer and the adhesive layer; and attaching a first cover layer using a first adhesive layer to the conductive layer. The first cover layer includes one or more precut access holes that align with one or more traces of the trace pattern.

Abstract: The present invention provides a liquid polysiloxane comprising a siloxane-thiourea segment and a crosslinkable functional group(s) selected from one or more ethylenically unsaturated groups, silyl hydride groups, alkylenethiol groups and combinations thereof.

Abstract: A battery pack for an electric vehicle or a hybrid vehicle may include a housing, a stack of battery cells disposed within the housing, and a cooling subassembly. The housing typically holds the cell stack together, and the cooling subassembly typically cools the cell stack to prevent damage to the battery cells and to maintain the performance of the battery cells. The cooling subassembly may include a cold plate defining a liquid flow channel and one or more thermoelectric devices (TEDs) that are operable to cool the cell stack when current is supplied thereto. Heat spreaders may be employed within the battery pack, and exemplary configurations of components to thermally and mechanically couple the cooling subassembly are described.

Abstract: An electrolysis apparatus for producing ammonia, the apparatus comprising: a cathode; an anode; an electrolyte; a current source; a supply for nitrogen; and a supply for an acid, wherein the acid comprises at least one acid selected from the group consisting of: HCl, HBr, and HI.

Abstract: A sensing system for a battery includes a flex foil substrate including a first cover layer. A conductive layer defines a trace pattern including traces. A second cover layer defines a first opening. The conductive layer is sandwiched between the first cover layer and the second cover layer. The first opening exposes a first trace and a second trace of the trace pattern. A busbar is attached to the first cover layer of the flex foil substrate. A temperature sensor is connected to the first trace and the second trace of the trace pattern in the first opening of the first cover layer.

Abstract: A battery pack for an electric vehicle or a hybrid vehicle may include a housing, a stack of battery cells disposed within the housing, and a cooling subassembly. The housing typically holds the cell stack together, and the cooling subassembly typically cools the cell stack to prevent damage to the battery cells and to maintain the performance of the battery cells. The cooling subassembly may include a cold plate defining a liquid flow channel and one or more thermoelectric devices (TEDs) that are operable to cool the cell stack when current is supplied thereto. Heat spreaders may be employed within the battery pack, and exemplary configurations of components to thermally and mechanically couple the cooling subassembly are described.

Abstract: The present invention provides a liquid polysiloxane comprising a siloxane-thiourea segment and a crosslinkable functional group(s) selected from one or more ethylenically unsaturated groups, silyl hydride groups, alkylenethiol groups and combinations thereof.

Abstract: A power management system for a vehicle includes a first battery monitoring module configured to monitor a first state of charge (SOC) of a first battery of the vehicle. The first battery has a first nominal voltage. A second battery monitoring module is configured to monitor a second SOC of a second battery of the vehicle. The second battery has a second nominal voltage that is greater than the first nominal voltage. A control module is configured to selectively apply power to a heater of the second battery based on an estimated value of the second SOC of the second battery at a next startup of an engine.

Abstract: A dry and solid fertiliser in the form of discreet particles is provided. The particles of the dry and solid fertiliser comprise a homogenous mixture of organic and inorganic materials. The inorganic material comprises at least one of the NPKS nutrients. The organic material comprises a carbon-labile substantially sterile product of organic waste.

Abstract: The present invention relates to a polymer composite for controlled release of an agent. In particular, the present invention relates to a stimuli-responsive polymer composite that can provide for controlled release of an agent in response to light. The polymer composite may be particularly suitable for the controlled delivery of a drug that is modulated by light.