Abstract: Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded DNA, for which knock-ins are notoriously inefficient for relying on random integration of homologous DNA sequences into the break site by repair proteins. To address these issues, described herein are novel recombinant fusion proteins that actively recruit linear DNA inserts in closer proximity to the genomic cleavage site, increasing integration efficiency of large DNA fragments into the genome. Such improvements to genomic editing technology allow one to use lower linear DNA concentrations without sacrificing efficiency and can be further combined with other features, such as fluorescent protein reporting systems.

Abstract: Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded DNA, for which knock-ins are notoriously inefficient for relying on random integration of homologous DNA sequences into the break site by repair proteins. To address these issues, described herein are novel recombinant fusion proteins that actively recruit linear DNA inserts in closer proximity to the genomic cleavage site, increasing integration efficiency of large DNA fragments into the genome. Such improvements to genomic editing technology allow one to use lower linear DNA concentrations without sacrificing efficiency and can be further combined with other features, such as fluorescent protein reporting systems.

Abstract: Described herein are methods and compositions for genomic editing. Endonucleases for genomic editing involve inducing breaks in double stranded DNA, for which knock-ins are notoriously inefficient for relying on random integration of homologous DNA sequences into the break site by repair proteins. To address these issues, described herein are novel recombinant fusion proteins that actively recruit linear DNA inserts in closer proximity to the genomic cleavage site, increasing integration efficiency of large DNA fragments into the genome. Such improvements to genomic editing technology allow one to use lower linear DNA concentrations without sacrificing efficiency and can be further combined with other features, such as fluorescent protein reporting systems.

Abstract: Arrow components, such as vanes and nocks, are provided with a light-emitting material for enhancing their visibility to the shooter, a camera, spectators, and/or others attempting to view the flight-path of the shot arrow during low-light conditions. In various embodiments, the light-emitting material is provided by a photo-luminescent material, a chemi-luminescent material, a refractive material, a reflective material, another material that will emit light in low-light conditions, or a composite of these. The light-emitting material is preferably selected for its ability to emit light, upon exposure to natural or artificial light and with no electric power source.

Abstract: Arrow components, such as vanes and nocks, are provided with a light-emitting material for enhancing their visibility to the shooter, a camera, spectators, and/or others attempting to view the flight-path of the shot arrow during low-light conditions. In various embodiments, the light-emitting material is provided by a photo-luminescent material, a chemi-luminescent material, a refractive material, a reflective material, another material that will emit light in low-light conditions, or a composite of these. The light-emitting material is preferably selected for its ability to emit light, upon exposure to natural or artificial light and with no electric power source.

Abstract: Disposable clothing articles for hunting and other outdoor activities are made of a low-cost, lightweight, breathable material, preferably a non-woven with particle barrier properties, and preferably include cinching elements for cinching closed with a good seal the hand and foot openings of the clothing to prevent the escape of human odors. The clothing articles are treated with one or more odor-reducing agents to absorb the human odors that pass through the clothing material. In an example method of making the clothing articles, a liquid odor-reducing agent is sprayed onto the clothing, one or two powder odor-reducing agents are sprinkled onto the inside and outside surfaces of the clothing, and the treated clothing article is stored in a sealable bag or other container.

Abstract: A bowhunting tracking-assist device on an arrow's shaft includes a tracer agent and an agent dispenser. The dispenser releases the agent when the arrow strikes a game animal, and the released agent identifies an enhanced-visibility trail of the fleeing animal. In an example embodiment, the dispenser has wells for holding the agent and a cover that displaces to release the agent when the arrow drives into the animal. The tracer agent preferably comprises one or more compounds that produce visible light to the naked eye and/or under a black light source. Example tracer agents include biological stains that produce visible light upon contact with blood, luminol or another chemiluminescent compound that releases light by a chemical reaction such as may occur when contacting blood, a basic salt such as sodium carbonate or another effervescence-inducing agent, a phosphorescent compound, or a fluorescent compound.

Abstract: A firearm ammunition device includes a cartridge with a projectile that is loaded with a tracer agent. When the projectile is fired and strikes a game animal, the impact causes the release and dispersal of the tracer agent from the projectile. The dispersed tracer agent identifies an enhanced-visibility trail of the fleeing animal. In example embodiments, the cartridge is provided by a centerfire cartridge, a shotgun cartridge, and a muzzleloading cartridge. The tracer agent preferably comprises one or more compounds that produce visible light to the naked eye and/or under a black light source. Example tracer agents include biological stains that produce visible light upon contact with blood, luminol or another chemiluminescent compound that releases light by a chemical reaction such as may occur when contacting blood, a basic salt such as sodium carbonate or another effervescence-inducing agent, a phosphorescent compound, or a fluorescent compound.

Abstract: Disposable clothing articles for hunting and other outdoor activities are made of a low-cost, lightweight, breathable material, preferably a non-woven with particle barrier properties, and preferably include cinching elements for cinching closed with a good seal the hand and foot openings of the clothing to prevent the escape of human odors. The clothing articles are treated with one or more odor-reducing agents to absorb the human odors that pass through the clothing material. In an example method of making the clothing articles, a liquid odor-reducing agent is sprayed onto the clothing, one or two powder odor-reducing agents are sprinkled onto the inside and outside surfaces of the clothing, and the treated clothing article is stored in a sealable bag or other container.

Abstract: A method for screening fiber polarization mode dispersion using a polarization optical time domain reflectometer. A pulse radiation is emitted into the fiber under test, and the backscattered radiation is measured by the POTDR and used to obtain a POTDR trace. A composite trace of more than one POTDR trace is obtained. The composite trace is then analyzed to compare the variation of signals along the length of the fiber, the variation in signals relating to the level of PMD along the length of the fiber. Because high levels of PMD correspond to localized levels of low variability, by setting the variability of signal threshold sufficiently low, fibers having unacceptably high localized PMD can be identified and removed.

Abstract: A meal data object is generated by a user, where the meal data object includes recipes and food items. The meal data object may more specifically include a description and a meal type for the meal data object. For each recipe of the meal data object, the meal data object may include a description, a dish type, and/or a meal part for the recipe. The meal data object may also include a description for each food item. The meal data object is published so that it is viewable by other users. The users can navigate the meal data objects to select desired meals. A shopping list for the food items of the meal data object can be generated, such that each food item is listed once in the shopping list regardless of the number of recipes of the meal data object within which the food item is present.

Abstract: Determining similarity among recipes is disclosed. A computer-implemented method of one embodiment of the invention receives a first recipe. The method determines one or more second recipes that are similar to the first recipe, and then outputs the one or more second recipes. The second recipes may be determined as being similar to the first recipe based on one or more different factors in one embodiment. Such factors may include: a weighted ingredient coefficient; a weighted same-type coefficient taking into account whether recipes are of the same type; a weighted same-title words coefficient taking into account the extent to which non-common title words of one recipe are also within the titles of other recipes; a weighted shared-keywords coefficient taking into account shared keywords among recipes; and, a weighted shared-ingredients coefficient taking into account the extent to which ingredients are shared among recipes.

Abstract: An improved hand-held hose spray for kitchen faucets includes interchangeable cleaning accessories for providing scouring, scrubbing, wiping and rinsing functions in the cleansing of kitchen articles and utensils concurrent with the operation and manipulation of the hose spray, eliminating the need for the user to release or replace the hose spray during the cleansing cycle.