Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A saliva-based testing method that bypasses the need for RNA isolation/purification is described herein. In experiments with inactivated SARS-CoV-2 virus spiked into saliva, this method has a limit of detection of 500-1000 viral particles per mL, rivalling the standard NP swab method. Initial studies showed excellent performance with 100 clinical samples. This saliva-based process is operationally simple, utilizes readily available materials, and can be easily implemented by existing testing sites thus allowing for high-throughput, rapid, and repeat testing of large populations.

Abstract: Approaches for estimating power consumption of a circuit based on a circuit design. For one or more modules of the design, data are input that indicate measured power consumption and circuit resources used by the one or more modules. For one or more other parts of the design, values of parameters are input that specify an operating speed and a resource count. Process-corner, voltage, and temperature values are input. An estimated level of power consumption is determined as a function of the measured power consumption, the values of the parameters, and the values of the process-corner, voltage, and temperature. Data indicative of the estimated level of power consumption are output.