Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A method for a media environment driven content distribution platform includes obtaining synchronization data derived from the content and ancillary data pegged to instants in the synchronization data derived from the content, and communicating the synchronization data derived from the content and the ancillary data pegged to the instants in the synchronization data derived from the content such that subsequent alignment of the synchronization data derived from the content to the content synchronizes the ancillary data pegged to the instants in the synchronization data derived from the content to the content.

Abstract: An apparatus to jointly measure oxygen utilization and tissue strain includes an imaging system and a computer processor operatively coupled to the imaging system. The computer processor is configured to control the imaging system to perform a pulse sequence on tissue of a subject. The computer processor also acquires oxygen utilization data and strain data responsive to the pulse sequence. The computer processor further determines an amount of strain on the tissue of the subject based at least in part on the strain data and an amount of oxygen utilization of the tissue of the subject based at least in part on the oxygen utilization data.

Abstract: A method for a media environment driven content distribution platform includes obtaining synchronization data derived from the content and ancillary data pegged to instants in the synchronization data derived from the content, and communicating the synchronization data derived from the content and the ancillary data pegged to the instants in the synchronization data derived from the content such that subsequent alignment of the synchronization data derived from the content to the content synchronizes the ancillary data pegged to the instants in the synchronization data derived from the content to the content.

Abstract: A method for a media environment driven content distribution platform includes obtaining synchronization data derived from the content and ancillary data pegged to instants in the synchronization data derived from the content, and communicating the synchronization data derived from the content and the ancillary data pegged to the instants in the synchronization data derived from the content such that subsequent alignment of the synchronization data derived from the content to the content synchronizes the ancillary data pegged to the instants in the synchronization data derived from the content to the content.

Abstract: A method for a media environment driven content distribution platform includes obtaining synchronization data derived from the content and ancillary data pegged to instants in the synchronization data derived from the content, and communicating the synchronization data derived from the content and the ancillary data pegged to the instants in the synchronization data derived from the content such that subsequent alignment of the synchronization data derived from the content to the content synchronizes the ancillary data pegged to the instants in the synchronization data derived from the content to the content.

Abstract: An apparatus to jointly measure oxygen utilization and tissue strain includes an imaging system and a computer processor operatively coupled to the imaging system. The computer processor is configured to control the imaging system to perform a pulse sequence on tissue of a subject. The computer processor also acquires oxygen utilization data and strain data responsive to the pulse sequence. The computer processor further determines an amount of strain on the tissue of the subject based at least in part on the strain data and an amount of oxygen utilization of the tissue of the subject based at least in part on the oxygen utilization data.

Abstract: Synchronizing ancillary data to content including audio includes obtaining a representation of the content's audio and ancillary data pegged to instants in the representation of the content's audio, and aligning the representation of the content's audio to the content's audio to synchronize the ancillary data pegged to the instants in the representation of the content's audio to the content.

Abstract: Described here are systems and methods for producing high-resolution three-dimensional (“3D”) relaxation parameter maps by calibrating high-resolution 3D magnetic resonance images. As one example, high-resolution longitudinal relaxation time (“T1”) maps can be generated based on images acquired using a T1-weighted pulse sequence, and as another example high-resolution transverse relaxation time (“T2”) maps can be generated based on images acquired using a T2-weighted pulse sequence. The high-resolution images can be calibrated, for example, using a lower resolution single slice relaxation parameter map. The methods described here utilize high-resolution 3D scans and low-resolution relaxation parameter maps that are commonly available on MRI systems. The calibration is a post-processing step used to create the high-resolution 3D relaxation parameter maps from these two types of scans.

Abstract: Synchronizing ancillary data to content including audio includes obtaining a representation of the content's audio and ancillary data pegged to instants in the representation of the content's audio, and aligning the representation of the content's audio to the content's audio to synchronize the ancillary data pegged to the instants in the representation of the content's audio to the content.

Abstract: A method for a media environment driven content distribution platform includes obtaining synchronization data derived from the content and ancillary data pegged to instants in the synchronization data derived from the content, and communicating the synchronization data derived from the content and the ancillary data pegged to the instants in the synchronization data derived from the content such that subsequent alignment of the synchronization data derived from the content to the content synchronizes the ancillary data pegged to the instants in the synchronization data derived from the content to the content.

Abstract: Described here are systems and methods for producing high-resolution three-dimensional (“3D”) relaxation parameter maps by calibrating high-resolution 3D magnetic resonance images. As one example, high-resolution longitudinal relaxation time (“T1”) maps can be generated based on images acquired using a T1-weighted pulse sequence, and as another example high-resolution transverse relaxation time (“T2”) maps can be generated based on images acquired using a T2-weighted pulse sequence. The high-resolution images can be calibrated, for example, using a lower resolution single slice relaxation parameter map. The methods described here utilize high-resolution 3D scans and low-resolution relaxation parameter maps that are commonly available on MRI systems. The calibration is a post-processing step used to create the high-resolution 3D relaxation parameter maps from these two types of scans.

Abstract: Systems and methods for converting grayscale values in magnetic resonance images having different image contrasts into normalized estimations of physiological quantities are provided. These methods provide consistency of data from scan-to-scan, which allows the data to be used for high-fidelity radiogenomic analyses. Imaging-derived radiogenomic heat maps, based on trained models of quantitative radiogenomic associations, can be generated from, the normalized images and can provide a novel technique to survey the often varied genetic landscape within a tumor.

Abstract: A method for a machine or group of machines to carry watermark data in an encoded audio data frame of an audio signal includes receiving the encoded audio data frame having encoded therein a portion of the audio signal. The encoded audio data frame includes a plurality of data blocks, wherein the plurality of data blocks includes, a synchronization information block, at least one encoded data block, and an error check block. The method further includes receiving modified watermark data as modified based on a masking threshold analysis of the audio signal and transforming the encoded audio data frame into a modified encoded audio data frame.

Abstract: Synchronizing ancillary data to content including audio includes obtaining a representation of the content's audio and ancillary data pegged to instants in the representation of the content's audio, and aligning the representation of the content's audio to the content's audio to synchronize the ancillary data pegged to the instants in the representation of the content's audio to the content.

Abstract: Synchronizing ancillary data to content including audio includes obtaining a representation of the content's audio and ancillary data pegged to instants in the representation of the content's audio, and aligning the representation of the content's audio to the content's audio to synchronize the ancillary data pegged to the instants in the representation of the content's audio to the content.

Abstract: A method for authenticating content via loudness signature includes receiving an input signal comprising a) an audio signal of the content and b) metadata including data indicating remotely measured loudness of the content, measuring loudness of the audio signal of the content to obtain a locally measured loudness of the content, and comparing the remotely measured loudness of the content to the locally measured loudness of the content to obtain an authentication indication based on the comparing.

Abstract: A system for perfusion and diffusion MR imaging of a portion of patient anatomy includes an RF (Radio Frequency) signal generator for generating RF excitation pulses in anatomy and enabling subsequent acquisition of associated RF echo data. A magnetic field gradient generator generates anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition in a three dimensional (3D) anatomical volume. The RF signal generator and the gradient generator acquire within a single MR imaging scan, perfusion image data of the 3D volume, at least partially in the presence of contrast agent, and diffusion image data of the 3D volume.

Abstract: A system for improving intelligibility or loudness of an audio program includes an encoder that receives signals of the audio program including at least one of left/front and right/front or left and right signals that include some anchor components of the audio program and to downmix the received signals to obtain left downmix and right downmix signals. The system includes a decoder that upmixes the left downmix and right downmix signals to obtain a center upmix signal that includes a majority of the anchor components including at least some anchor components that were included in the left/front and right/front signals or the left and right signals. The system also includes a system output that provides the center upmix signal to process at least one of the signals of the audio program based on the center upmix signal to improve intelligibility or loudness of the audio program.

Abstract: A method for a machine or group of machines to carry watermark data in an encoded audio data frame of an audio signal includes receiving the encoded audio data frame having encoded therein a portion of the audio signal. The encoded audio data frame includes a plurality of data blocks, wherein the plurality of data blocks includes, a synchronization information block, at least one encoded data block, and an error check block. The method further includes receiving modified watermark data as modified based on a masking threshold analysis of the audio signal and transforming the encoded audio data frame into a modified encoded audio data frame.