Patents by Inventor Timothy J. Fischer
Timothy J. Fischer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10527526Abstract: Compositions and methods for preparing a sample for immunological staining are provided. Compositions include kits comprising a first solution comprising a surfactant and a second solution comprising a chaotropic agent. Methods comprise contacting a sample, such as cells or tissues, with a first solution comprising a surfactant and then contacting the sample with a second solution comprising a chaotropic agent. The method does not require extreme heat for antigen retrieval and therefore, maintains the cellular morphology of the sample.Type: GrantFiled: November 2, 2012Date of Patent: January 7, 2020Assignee: Tripath Imaging, Inc.Inventors: Timothy J. Fischer, Ramona R. Nelson, Adriann J. Taylor, Clark M. Whitehead
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Patent number: 9833529Abstract: Sterilization cassette systems, instrument retention systems for use with a sterilization cassette, and configurable instrument retention members are disclosed that are suitable at least for holding medical and/or dental instruments during sterilization in an autoclave.Type: GrantFiled: June 25, 2013Date of Patent: December 5, 2017Assignee: HU-FRIEDY MFG. CO., LLCInventors: David W. Tipton, Timothy J. Fischer, David K. Platt, Chantel D. Willis, Jennifer Radovich Naylor, Marjavis J. Matthis, Mark Kurth, Timothy Payne, Philip Anthony
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Patent number: 8539625Abstract: A gap shield assembly for shielding an open area between a first section of a bed and an adjacent second section of the bed. The gap shield has a first shield member and a second shield member. The second shield member is rotatably connected to the second section of the bed. The first shield member is rotatably and translationally connected to the second shield member. The gap shield assembly also has a width extender assembly connecting the first shield member to the first section of the bed to allow the first shield member to move inwardly and outwardly with respect to a centerline of the bed while still shielding the open area between the first and second sections of the bed.Type: GrantFiled: September 23, 2010Date of Patent: September 24, 2013Assignee: Kreg Medical Inc.Inventors: Craig Poulos, Joseph Immordino, Patrick Harris, Timothy J. Fischer, John Peklo
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Patent number: 8476033Abstract: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.Type: GrantFiled: July 27, 2012Date of Patent: July 2, 2013Assignee: TriPath Imaging, Inc.Inventors: Robert L. Cheek, Eric P. Dixon, Timothy J. Fischer, John W. Groelke, Steven L. Knapp, Stephen G. Simkins, Clark M. Whitehead
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Patent number: 8372591Abstract: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.Type: GrantFiled: September 28, 2011Date of Patent: February 12, 2013Assignee: Tripath Imaging, Inc.Inventors: Douglas P. Malinowski, Timothy J. Fischer, Adriann J. Taylor
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Publication number: 20130022998Abstract: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for a glycodelin epitope of a disclosed monoclonal glycodelin antibody and methods of using these polypeptides in the production of glycodelin antibodies are also encompassed by the present invention.Type: ApplicationFiled: July 27, 2012Publication date: January 24, 2013Applicant: TriPath Imaging, Inc.Inventors: Robert L. Cheek, Eric P. Dixon, Timothy J. Fischer, John W. Groelke, Steven L. Knapp, Stephen G. Simkins, Clark M. Whitehead
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Patent number: 8252904Abstract: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to glycodelin. Monoclonal antibodies having the binding characteristics of a glycodelin antibody of the invention and monoclonal antibodies that bind to a glycodelin epitope of a disclosed antibody are further provided. Hybridoma cell lines that produce a glycodelin monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed glycodelin monoclonal antibodies and for practicing the methods of the invention are further provided.Type: GrantFiled: March 5, 2010Date of Patent: August 28, 2012Assignee: Tripath Imaging, Inc.Inventors: Robert L. Cheek, Eric P. Dixon, Timothy J. Fischer, John W. Groelke, Steven L. Knapp, Stephen G. Simkins, Clark M. Whitehead
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Publication number: 20120015375Abstract: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.Type: ApplicationFiled: September 28, 2011Publication date: January 19, 2012Applicant: TriPath Imaging, Inc.Inventors: Douglas P. Malinowski, Timothy J. Fischer, Adriann J. Taylor
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Patent number: 8076093Abstract: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM2 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.Type: GrantFiled: August 21, 2009Date of Patent: December 13, 2011Assignee: Tripath Imaging, Inc.Inventors: Douglas P. Malinowski, Timothy J. Fischer, Adriann J. Taylor
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Patent number: 8058404Abstract: Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM6 or MCM7. Monoclonal antibodies having the binding characteristics of an MCM6 or MCM7 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM6 or MCM7 monoclonal antibody of the invention are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM6, MCM7, or both MCM6 and MCM7 in a cervical sample from a patient. Kits for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an MCM6 or an MCM7 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.Type: GrantFiled: July 22, 2008Date of Patent: November 15, 2011Assignee: Tripath Imaging, Inc.Inventors: Douglas P. Malinowski, Timothy J. Fischer, Adriann J. Taylor
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Publication number: 20110247141Abstract: A gap shield assembly for shielding an open area between a first section of a bed and an adjacent second section of the bed. The gap shield has a first shield member and a second shield member. The second shield member is rotatably connected to the second section of the bed. The first shield member is rotatably and translationally connected to the second shield member. The gap shield assembly also has a width extender assembly connecting the first shield member to the first section of the bed to allow the first shield member to move inwardly and outwardly with respect to a centerline of the bed while still shielding the open area between the first and second sections of the bed.Type: ApplicationFiled: September 23, 2010Publication date: October 13, 2011Inventors: Craig Poulos, Joseph Immordino, Patrick Harris, Timothy J. Fischer, John Peklo
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Publication number: 20110163885Abstract: A therapeutic mattress is provided having a base layer, a plurality of separate air cell sections, an air source and a valve. The separate air cell sections have a plurality of fluidly interconnected air cell members extending vertically from a bottom wall. The air cell members of the air cell sections are independently moveable in a plurality of directions. The valve is fluidly connected to the plurality of separate air cell sections. The air source is connected to the valve to independently increase the air pressure in the air cell sections to a desired air pressure.Type: ApplicationFiled: July 9, 2010Publication date: July 7, 2011Inventors: Craig Poulos, Timothy J. Fischer, Joseph Immordino
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Patent number: 7899623Abstract: Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be extracted from an image of a body sample, such as a histological slide, that has been exposed to one or more biomarkers so as to establish a prognostic decision rule based on one or more of the extracted features such that the decision rule yields a prognosis that is optimally predictive of actual patient outcome. Thus, the methods and computer program products provided yield optimally predictive prognoses to assist clinicians in developing strategies for effective patient care management.Type: GrantFiled: September 22, 2005Date of Patent: March 1, 2011Assignee: TriPath Imaging, Inc.Inventors: Raphael Marcelpoil, Clark Merrill Whitehead, Timothy J. Fischer
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Publication number: 20110038883Abstract: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.Type: ApplicationFiled: October 29, 2010Publication date: February 17, 2011Applicant: TriPath Imaging, IncInventors: Robert L. Cheek, Timothy J. Fischer, John W. Groelke
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Patent number: 7846692Abstract: Compositions and methods for diagnosing ovarian cancer in a patient and for identifying patients with an increased likelihood of having ovarian cancer are provided. The compositions include novel monoclonal antibodies, and variants and fragments thereof, that specifically bind to HE4. Monoclonal antibodies having the binding characteristics of an HE4 antibody of the invention are further provided. Hybridoma cell lines that produce an HE4 monoclonal antibody of the invention are also disclosed herein. The compositions find use in diagnostic methods as well as in screening methods for identifying patients having an increased likelihood of having ovarian cancer. Kits comprising one or more of the disclosed HE4 monoclonal antibodies and for practicing the methods of the invention are further provided. Polypeptides comprising the amino acid sequence for an HE4 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present invention.Type: GrantFiled: March 7, 2008Date of Patent: December 7, 2010Assignee: Tripath Imaging, Inc.Inventors: Robert L. Cheek, Timothy J. Fischer, John W. Groelke
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Patent number: D704855Type: GrantFiled: June 16, 2012Date of Patent: May 13, 2014Assignee: Hu-Friedy Mfg. Co., LLCInventors: David W. Tipton, Timothy J. Fischer, David K. Platt, Chantel D. Willis, Jennifer Radovich Naylor, Marjavis J. Matthis, Mark Kurth, Timothy Payne, Philip Anthony
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Patent number: D705442Type: GrantFiled: April 15, 2013Date of Patent: May 20, 2014Assignee: Hu-Friedy Mfg. Co., LLCInventors: David W. Tipton, Timothy J. Fischer, David K. Platt, Chantel D. Willis, Jennifer R. Naylor, Marjavis J. Matthis, Mark Kurth, Timothy Payne, Philip Anthony
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Patent number: D720080Type: GrantFiled: March 20, 2014Date of Patent: December 23, 2014Assignee: HU-Friedy Mfg. Co., LLCInventors: David W. Tipton, Timothy J. Fischer, David K. Platt, Chantel D. Willis, Jennifer Radovich Naylor, Marjavis J. Matthis, Mark Kurth, Timothy Payne, Philip Anthony
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Patent number: D721441Type: GrantFiled: March 20, 2014Date of Patent: January 20, 2015Assignee: Hu-Friedy Mfg. Co., LLCInventors: David W. Tipton, Timothy J. Fischer, David K. Platt, Chantel D. Willis, Jennifer Radovich Naylor, Marjavis J. Matthis, Mark Kurth, Timothy Payne, Philip Anthony
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Patent number: D764068Type: GrantFiled: December 4, 2014Date of Patent: August 16, 2016Assignee: HU-FRIEDY MFG. CO., LLCInventors: David W. Tipton, Timothy J. Fischer, David K. Platt, Chantel D. Willis, Jennifer Radovich Naylor, Marjavis J. Matthis, Mark Kurth, Timothy Payne, Philip Anthony