Patents by Inventor Timothy J. Guzi

Timothy J. Guzi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel imidazopyrazines as cyclin dependent kinase inhibitors
    Publication number: 20040063715
    Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
    Type: Application
    Filed: September 19, 2003
    Publication date: April 1, 2004
    Applicant: SCHERING CORPORATION
    Inventors: Kamil Paruch, Timothy J. Guzi, Michael P. Dwyer, Ronald J. Doll, Viyyoor M. Girijavallabhan, Alan Mallams
  • 17-Beta hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
    Publication number: 20030232837
    Abstract: There are disclosed compounds of the formula (I): 1
    Type: Application
    Filed: October 15, 2002
    Publication date: December 18, 2003
    Applicant: Schering Corporation
    Inventors: Timothy J. Guzi, Kamil Paruch
  • Treatment of malaria with farnesyl protein transferase inhibitors
    Publication number: 20030092705
    Abstract: Disclosed is a method of treating Malaria comprising administering an effective amount of an FPT inhibitor to a patient in need of such treatment alone or in combination with an additional antimalarial agent and/or agent for reversing antimalarial resistance.
    Type: Application
    Filed: January 18, 2002
    Publication date: May 15, 2003
    Applicant: Schering Corporation
    Inventors: William T. Windsor, Patricia C. Weber, James J-S Wang, Corey O. Strickland, F. George Njoroge, Timothy J. Guzi, Viyyoor M. Girijavallabhan, Johan A. Ferreira, Jagdish A. Desai, Alan B. Cooper, Michael Gelb
  • Farnesyl protein transferase inhibitors
    Patent number: 6399615
    Abstract: Novel compounds of the formula: wherein a represents N or NO, R1 and R3 are halo, R2 and R4 are independently H or halo provided that at least one is H, X is C, CH or N, and T represents wherein R5 is H (C1-C6)alkyl or a bond; b and c are independently 0 to 3 and Y is a three, four, five or six membered cycloalkyl ring, pyridyl, pyrazinyl or phenyl are disclosed. Pharmaceutical Compositions containing such compounds, methods of inhibiting farnesyl protein transferase and methods for treating tumor cells using such compounds or compositions are also disclosed.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: June 4, 2002
    Assignee: Schering Corporation
    Inventors: Timothy J. Guzi, Dinanath F. Rane
  • Farnesyl protein transferase inhibitors
    Patent number: 6159984
    Abstract: Novel compounds of the formula: ##STR1## wherein a represents N or NO, R.sup.1 and R.sup.3 are halo, R.sup.2 and R.sup.4 are independently H or halo provided that at least one is H, X is C, CH or N, and T represents ##STR2## wherein R.sub.5 is H (C.sub.1 -C.sub.6)alkyl or a bond; b and c are independently 0 to 3 and Y is a three, four, five or six membered cycloalkyl ring, pyridyl, pyrazinyl or phenyl are disclosed. Pharmaceutical Compositions containing such compounds, methods of inhibiting farnesyl protein transferase and methods for treating tumor cells using such compounds or compositions are also disclosed.
    Type: Grant
    Filed: June 15, 1998
    Date of Patent: December 12, 2000
    Assignee: Schering Corporation
    Inventors: Timothy J. Guzi, Dinanath F. Rane