Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: Embodiments of the present invention are generally directed to detection of non-compliant payment requests or payment orders. In particular, the invention detects non-compliance with travel rules put in place by multiple countries throughout the world. The systems and methods for capturing non-compliant payments may be adapted for various funds transfer channels or systems, including but not limited to Society for Worldwide Interbank Financial Telecommunication (SWIFT), Federal Reserve Wire Network or FedWire, Clearing House Interbank Payments System (CHIPS), or other public or proprietary funds transfer or payment systems.

Abstract: The present invention provides an apparatus and method for evaluating the integrity of a seal on liquid-filled container. According to one aspect of the invention, the apparatus comprises a tank for containing a liquid solution and a clamp with a first and second member between which the container is engaged. The clamp is positioned with respect to the tank such that a portion of the container properly situated in the clamp will extend into the tank and contact the liquid solution. A ram and cylinder are operatively connected to the clamp to engage the container. A seat is provided to support a portion of the container such that at least a portion of the container supported by the seat will extend into the tank. A drill is provided to pierce a surface of the container to make an opening. The drill is positioned such that the opening can be made while the container is in the clamp and/or the seat such that at least a portion of the container extends into the tank.

Abstract: The present invention provides an apparatus and method for evaluating the integrity of a seal on liquid-filled container. According to one aspect of the invention, the apparatus comprises a tank for containing a liquid solution and a clamp with a first and second member between which the container is engaged. The clamp is positioned with respect to the tank such that a portion of the container properly situated in the clamp will extend into the tank and contact the liquid solution. A ram and cylinder are operatively connected to the clamp to engage the container. A seat is provided to support a portion of the container such that at least a portion of the container supported by the seat will extend into the tank. A drill is provided to pierce a surface of the container to make an opening. The drill is positioned such that the opening can be made while the container is in the clamp and/or the seat such that at least a portion of the container extends into the tank.

Abstract: The present invention provides an apparatus and method for evaluating the integrity of a seal on liquid-filled container. According to one aspect of the invention, the apparatus comprises a tank for containing a liquid solution and a clamp with a first and second member between which the container is engaged. The clamp is positioned with respect to the tank such that a portion of the container properly situated in the clamp will extend into the tank and contact the liquid solution. A ram and cylinder are operatively connected to the clamp to engage the container. A seat is provided to support a portion of the container such that at least a portion of the container supported by the seat will extend into the tank. A drill is provided to pierce a surface of the container to make an opening. The drill is positioned such that the opening can be made while the container is in the clamp and/or the seat such that at least a portion of the container extends into the tank.

Abstract: The present invention provides an apparatus and method for evaluating the integrity of a seal on liquid-filled container. According to one aspect of the invention, the apparatus comprises a tank for containing a liquid solution and a clamp with a first and second member between which the container is engaged. The clamp is positioned with respect to the tank such that a portion of the container properly situated in the clamp will extend into the tank and contact the liquid solution. A ram and cylinder are operatively connected to the clamp to engage the container. A seat is provided to support a portion of the container such that at least a portion of the container supported by the seat will extend into the tank. A drill is provided to pierce a surface of the container to make an opening. The drill is positioned such that the opening can be made while the container is in the clamp and/or the seat such that at least a portion of the container extends into the tank.

Abstract: The present invention provides a method and composition for controlling the growth of microorganisms in aqueous systems, such as industrial process waters. The method includes the steps of adding a synergistically effective amount of a biocide, 2-bromo-2-nitrostyrene ("BNS"), and an oxidant, peracetic acid, to industrial process waters to control microorganism growth. The composition of the present invention comprises a synergistically effective amount of a biocide, 2-bromo-2-nitrostyrene, and an oxidant, peracetic acid, to control microorganism growth. The method and composition of the present invention are particularly effective in the treatment of pulp and paper water processing systems.

Abstract: A machine for picking up seeds from a mass of seeds and depositing the seeds individually comprises a row of suction heads each having a suction duct terminating in an orifice and a container for holding the mass of seeds. The row of heads are pivotally mounted and are provided with a driving mechanism which swings the heads to and fro along a path between a pick-up position in which each of the orifices is adjacent the container and a discharge position in which seeds picked up by suction through the orifices are discharged. In order to enable each head to discharge at the discharge position only a single natural seed rather than a pelleted seed, a wiper member is provided and extends parallel to the row of heads in their path between the pick-up position and the discharge position. The wiper member has a curved surface and the heads swing close to this surface just before they reach the discharge position.