Patents by Inventor Timothy J. Jegla

Timothy J. Jegla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING HYPERALGESIA
    Publication number: 20090175882
    Abstract: This invention provides compounds which specifically inhibit TRPA1 but not other members of the thermoTRP ion channel family. Also provided in the invention are methods of using TRPA1-specific inhibitors to treat or alleviate pains mediated by noxious mechanosensation.
    Type: Application
    Filed: February 21, 2007
    Publication date: July 9, 2009
    Applicants: IRM LLC, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Ardem Patapoutian, Timothy J. Jegla
  • Methods for identifying modulators of cyclic nucleotide-gated cation channels
    Patent number: 7514208
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.
    Type: Grant
    Filed: April 17, 2007
    Date of Patent: April 7, 2009
    Assignee: ICAgen, Inc.
    Inventors: Christopher D. Creech, Timothy J. Jegla
  • CNG2B: A NOVEL HUMAN CYCLIC NUCLEOTIDE-GATED ION CHANNEL
    Publication number: 20080145943
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.
    Type: Application
    Filed: April 17, 2007
    Publication date: June 19, 2008
    Applicant: ICAgen, Inc.
    Inventors: Christopher D. Creech, Timothy J. Jegla
  • Cyclic nucleotide-gated cation channel subunit 3B (CNG3B) polypeptides
    Patent number: 7371823
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.
    Type: Grant
    Filed: October 23, 2006
    Date of Patent: May 13, 2008
    Assignee: Icagen, Inc.
    Inventors: Christopher D. Creech, Timothy J. Jegla
  • Antibodies to human Elk, a voltage-gated potassium channel subunit
    Patent number: 7355009
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
    Type: Grant
    Filed: October 15, 2004
    Date of Patent: April 8, 2008
    Assignee: Icagen, Inc.
    Inventors: Timothy J. Jegla, Alan Wickenden
  • Human HAC3
    Patent number: 7169893
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: January 30, 2007
    Assignee: Icagen, Incorporated
    Inventor: Timothy J. Jegla
  • Human HAC3
    Patent number: 7153668
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
    Type: Grant
    Filed: April 13, 2000
    Date of Patent: December 26, 2006
    Assignee: Icagen, Incorporated
    Inventor: Timothy J. Jegla
  • Isolated nucleic acids encoding cyclic nucleotide-gated cation channel subunit 3B (CNG3B) polypeptides
    Patent number: 7141419
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.
    Type: Grant
    Filed: May 14, 2001
    Date of Patent: November 28, 2006
    Assignee: Icagen, Inc.
    Inventors: Christopher D. Creech, Timothy J. Jegla
  • Human cyclic nucleotide-gated cation channel polypeptide
    Patent number: 7053183
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: May 30, 2006
    Assignee: Icagen, Inc.
    Inventors: Christopher D. Creech, Timothy J. Jegla
  • KCNQ5, a novel potassium channel
    Patent number: 7049137
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of KCNQ5, antibodies to KCNQ5, methods of detecting KCNQ5, methods of screening for potassium channel activators and inhibitors using biologically active KCNQ5, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising KCNQ5.
    Type: Grant
    Filed: March 15, 2001
    Date of Patent: May 23, 2006
    Assignee: Icagen, Inc.
    Inventor: Timothy J. Jegla
  • Human cyclic nucleotide-gated channel polypeptide
    Patent number: 6933147
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG2B, antibodies to CNG2B, methods of detecting CNG2B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG2B. The invention further provides, in a computer system, a method of screening for mutations of human CNG2B genes as well as a method for identifying a three-dimensional structure of human CNG2B polypeptides.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: August 23, 2005
    Assignee: ICAgen, Inc.
    Inventors: Christopher D. Creech, Timothy J. Jegla
  • Human Elk, a voltage-gated potassium channel subunit
    Patent number: 6833440
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: December 21, 2004
    Assignee: Icagen, Incorporated
    Inventors: Timothy J. Jegla, Alan Wickenden
  • CNG3B: a novel cyclic nucleotide-gated cation channel
    Publication number: 20040137433
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of CNG3B, antibodies to CNG3B, methods of detecting CNG3B, and methods of screening for modulators of cyclic nucleotide-gated ion channels using biologically active CNG3B. The invention further provides, in a computer system, a method of screening for mutations of human CNG3B genes as well as a method for identifying a three-dimensional structure of human CNG3B polypeptides.
    Type: Application
    Filed: May 14, 2001
    Publication date: July 15, 2004
    Inventors: Christopher D. Creech, Timothy J. Jegla
  • Kv6.2, a voltage-gated potassium channel subunit
    Publication number: 20040126849
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Kv6.2, antibodies to Kv6.2, methods of detecting Kv6.2, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active Kv6.2, and kits for screening for activators and inhibitors of voltage gated potassium channels comprising Kv6.2.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 1, 2004
    Applicant: ICAgen, Incorporated
    Inventor: Timothy J. Jegla
  • Human Eag2
    Patent number: 6753412
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: June 22, 2004
    Assignee: Icagen, Incorporated
    Inventors: Timothy J. Jegla, Yi Liu
  • Kv6.2, a voltage-gated potassium channel subunit
    Patent number: 6680180
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Kv6.2, antibodies to Kv6.2, methods of detecting Kv6.2, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active Kv6.2, and kits for screening for activators and inhibitors of voltage gated potassium channels comprising Kv6.2.
    Type: Grant
    Filed: February 22, 2001
    Date of Patent: January 20, 2004
    Assignee: Icagen, Incorporated
    Inventor: Timothy J. Jegla
  • Human Eag2
    Publication number: 20030211529
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.
    Type: Application
    Filed: April 22, 2003
    Publication date: November 13, 2003
    Applicant: ICAgen, Incorporated
    Inventors: Timothy J. Jegla, Yi Liu
  • Human Eag2
    Patent number: 6586179
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of Eag2, antibodies to Eag2, methods of detecting Eag2, and methods of screening for modulators of Eag2 potassium channels using biologically active Eag2. The invention further provides, in a computer system, a method of screening for mutations of human Eag2 genes as well as a method for identifying a three-dimensional structure of Eag2 polypeptide monomers.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: July 1, 2003
    Assignee: ICAgen, Incorporated
    Inventors: Timothy J. Jegla, Yi Liu
  • Human Elk, a voltage-gated potassium channel subunit
    Publication number: 20030077731
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hElk, antibodies to hElk, methods of detecting hElk, methods of screening for voltage-gated potassium channel activators and inhibitors using biologically active hElk, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising hElk.
    Type: Application
    Filed: May 28, 2002
    Publication date: April 24, 2003
    Applicant: ICAgen, Incorporated
    Inventors: Timothy J. Jegla, Alan Wickenden
  • Human HAC3
    Publication number: 20030044889
    Abstract: The invention provides isolated nucleic acid and amino acid sequences of hHAC3, antibodies to hHAC3, methods of detecting hHAC3, and methods of screening for modulators hyperpolarization-activated cation channels using biologically active hHAC3. The invention further provides, in a computer system, a method of screening for mutations of human HAC3 genes as well as a method for identifying a three-dimensional structure of human HAC3 polypeptides.
    Type: Application
    Filed: April 13, 2000
    Publication date: March 6, 2003
    Inventor: Timothy J. Jegla