Abstract: Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 ?m. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.

Abstract: Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 ?m. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.

Abstract: The disclosure provides a device and methods for delivering a multi-component fluid. In some cases, the device may comprise a tube, a mixer, and a nozzle. The tube may comprise a plurality of lumens carrying components of a multi-component fluid separately, and a dispersant. The mixer may receive and mix the separate multiple components to form the multi-component fluid. The dispersant may travel in a dispersant passageway disposed within the mixer. The multi-component fluid and the dispersant may be delivered through a nozzle outlet. In some cases, the dispersant and/or nozzle aerosolize the delivered multi-component fluid.

Abstract: Provided are methods, devices and compositions for reducing and/or inhibiting postsurgical tissue adhesion using a hydrogel film disposed onto a target tissue, thereby providing an adhesion barrier that remains over said target tissue for a prescribed period of time. In some embodiments, the hydrogel film is formed by the gelation of a pre-gel mixture applied onto the target tissue as a plurality of particles having an average maximum dimension, such as diameter, of at most about 500 ?m. In some embodiments, the hydrogel film has a minimum storage modulus of 100 Pa. In some embodiments, the pre-gel mixture comprises an ECM digest having a collagen to carbohydrate ratio (by mass) of at least 70:1.