Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for upregulating MHC class II in cancer cells (e.g., a hematological cancer cell). Also provided are methods of treatment for subjects suffering from hematological cancers, comprising administration of interferon-? (IFN-?). The methods of treatment provided herein may be particularly suitable for subjects who have received an allogenic transplant or have suffered a relapse.

Abstract: Among the various aspects of the present disclosure is the provision of methods and compositions for upregulating MHC class II in cancer cells (e.g., a hematological cancer cell). Also provided are methods of treatment for subjects suffering from hematological cancers, comprising administration of interferon-? (IFN-?). The methods of treatment provided herein may be particularly suitable for subjects who have received an allogenic transplant or have suffered a relapse.

Abstract: An occlusion device (e.g., for treatment of the left atrial appendage) includes a framework and a biocompatible covering disposed over at least a part of the framework. The framework may include a proximal portion, a middle portion, and a distal portion, wherein: the proximal portion includes a first hub that has a fixed first diameter; the middle portion has a second diameter and includes a plurality of beams extending from the first hub to a distal portion, wherein each of the plurality of beams is connected to an adjacent beam by a first circumferentially extending column of strut pairs; and the distal portion has a third diameter. In one or more embodiments, the framework includes improved circumferential strength and minimizes foreshortening.

Abstract: A device for occluding a target body lumen, comprises a wire structure defining a wire structure lumen extending therethrough and movable between a reduced diameter insertion configuration and an expanded diameter deployed configuration and a basket structure extending across the wire structure lumen and including therein a cell growth promoting agent to promote cell growth across the wire structure lumen to occlude the target body lumen.

Abstract: Occlusion device for an atrial appendage, the device having proximal and distal ends and a central axis and comprising a cage-like structure formed of struts, the struts having proximal strut ends and distal strut ends, wherein at the proximal end of the device the struts extend towards the central axis and are connected to each other at their proximal strut ends, and wherein at least some of the struts are connected to each other at their distal strut ends within the cage-like structure so that the struts form an atraumatic distal end of the device.

Abstract: In one embodiment of the invention, a stent may be provided comprising a first undulating band having alternating peaks and troughs, a second undulating band having alternating peaks and troughs, a first substantially longitudinal connector extending between the first and second undulating bands and a second very short connector extending between the first and second undulating bands, the first connector substantially longer than the second very short connector.

Abstract: Segmented articulatable stent of open structure comprised of end-connected struts of first and second lengths making up first and second segments with angular interconnects between adjacent first and second segments.

Abstract: In one embodiment of the invention, a stent may be provided comprising a first undulating band having alternating peaks and troughs, a second undulating band having alternating peaks and troughs, a first substantially longitudinal connector extending between the first and second undulating bands and a second very short connector extending between the first and second undulating bands, the first connector substantially longer than the second very short connector.

Abstract: Segmented articulatable stent of open structure comprised of end-connected struts of first and second lengths making up first and second segments with angular interconnects between adjacent first and second segments.

Abstract: Segmented articulatable stent of open structure comprised of end-connected struts of first and second lengths making up first and second segments with angular interconnects between adjacent first and second segments.

Abstract: Segmented articulatable stent of open structure comprised of end-connected struts of first and second lengths making up first and second segments with angular interconnects between adjacent first and second segments.

Abstract: Improved stent configurations exhibiting limited recoil, resistance to compression and improved longitudinal flexibility.

Abstract: A device for occluding a target body lumen, comprises a wire structure defining a wire structure lumen extending therethrough and movable between a reduced diameter insertion configuration and an expanded diameter deployed configuration and a basket structure extending across the wire structure lumen and including therein a cell growth promoting agent to promote cell growth across the wire structure lumen to occlude the target body lumen.

Abstract: A generally cylindrical, radially expandable stent may be composed of a plurality of interconnected multibonate cell structures. The cells have three or more enlarged end portions radiating from a common center within the cell. The cells may be of tribonate or higher order multibonate configuration. Stents composed up of a series of generally multibonate cell elements are also disclosed.

Abstract: A generally cylindrical, radially expandable stent may be composed of a plurality of interconnected multibonate cell structures. The cells have three or more enlarged end portions radiating from a common center within the cell. The cells may be of tribonate or higher order multibonate configuration. Stents composed up of a series of generally multibonate cell elements are also disclosed.

Abstract: A flexible tubular stent including loosely interlocked annular elements without intersections or cross-over points.

Abstract: A stent comprises at least one band of interconnected cells selected from the group consisting of S-shaped cells and mirror image S-shaped cells. Each cell has a top end and a bottom end. The top end of each cell is attached to the bottom end of an adjacent cell in the band. Adjacent bands may abut one another or may be joined by connecting members.

Abstract: In one embodiment of the invention, a stent may be provided comprising a first undulating band comprising a series of alternating first peaks and first troughs and a second undulating band comprising a series of alternating second peaks and second troughs. The first undulating band has a first wavelength and a first amplitude and the second undulating band has a second wavelength and a second amplitude where the second amplitude is different from the first amplitude and the second wavelength is different from the first wavelength. A plurality of longitudinally oriented first connectors extend between the first peaks and second peaks.

Abstract: In one embodiment of the invention, a stent may be provided comprising a first undulating band having alternating peaks and troughs, a second undulating band having alternating peaks and troughs, a first substantially longitudinal connector extending between the first and second undulating bands and a second very short connector extending between the first and second undulating bands, the first connector substantially longer than the second very short connector.

Abstract: Improved stent configurations exhibiting limited recoil, resistance to compression and improved longitudinal flexibility.