Abstract: Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) is provided by delivering specialized pulsed electric field energy to target tissue areas in a specific dose so as to obtain a superior outcome. The specialized PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. The specialized PEF energy provides superior outcomes to radiofrequency ablation and irreversible electroporation.

Abstract: An electrophoretic display includes an electrophoretic medium having a non-polar fluid and two sets of charged pigment particles dispersed in the non-polar fluid and movable through the non-polar fluid under influence of an electric field. The two sets of charged pigment particles have different optical characteristics from each other. The display also includes a light-transmissive electrode on one side of the electrophoretic medium, a rear electrode on an opposite side of the electrophoretic medium, and a dielectric layer having a dielectric constant greater than 5 between the electrophoretic medium and the light-transmissive electrode or between the electrophoretic medium and the rear electrode configured to reduce electrode electrochemical degradation and buildup of remnant voltages in the display.

Abstract: An electrowetting system for actuating droplets of a first composition and of a second composition. The system includes: a plurality of electrodes configured to manipulate droplets of fluid in a microfluidic space, each electrode being coupled to circuitry which applies driving voltages to the electrode; and a processing unit operably connected to a look up table correlating drive sequences to chemical species and at least one composition parameter. The processing unit is configured to: receive data of a first chemical species and a first composition parameter of the first composition; receive data of a second chemical species and a second composition parameter of the second composition; correlate a first drive sequence with the first chemical species and the first composition parameter; correlate a second drive sequence with the second chemical species and the second composition parameter; and output the first drive sequence and the second drive sequence to the electrodes.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for characterizing radio propagation channels. One method includes receiving, at a first modem, a first unit of communication over a radio frequency (RF) communication path from a second modem, wherein the first modem and the second modem process information for RF communications. The first modem identifies fields in the first unit of communication, the fields used to analyze the RF communication path. The first modem extracts data from the fields. The first modem accesses a channel model for approximating a channel representative of the RF communication path from the first modem to the second modem, wherein the channel model includes machine learning models. The first modem trains the channel model using the extracted data. The first modem applies the trained channel model to simulate a set of channel effects associated with the communication path.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for adversarially generated communication. In some implementations, first information is used as input for a generator machine-learning network. Information is taken from both the generator machine-learning network and target information that includes sample signals or other data. The information is sent to a discriminator machine-learning network which produces decision information including whether the information originated from the generator machine-learning network or the target information. An optimizer takes the decision information and performs one or more iterative optimization techniques which help determine updates to the generator machine-learning network or the discriminator machine-learning network.

Abstract: An electro-optic display including a first subpixel electrode and a second subpixel electrode associated with a display pixel, and an electrophoretic display medium disposed between a common electrode and the first and second subpixel electrodes. The electro-optic display also includes a display controller circuit in electrical communication with the common electrode and a first transistor associated with the display pixel. The display controller circuit is capable of applying waveforms to the display pixel by applying one or more time-dependent voltages between the common electrode and the first subpixel electrode via the first transistor, where the one or more time-dependent voltages are applied to the first subpixel electrode. The electro-optic display also includes a second transistor in electrical communication with the first subpixel electrode and the second subpixel electrode.

Abstract: An active molecule delivery system whereby active molecules can be released on demand and/or a variety of different active molecules can be delivered from the same system and/or different concentrations of active molecules can be delivered from the same system. The invention is well-suited for delivering pharmaceuticals to patients transdermally. In some embodiments, the system includes two separate reservoirs and a mixing area thereby allowing precursors to be mixed immediately before transdermal delivery.

Abstract: An electrowetting system for actuating droplets of a first composition and of a second composition. The system includes: a plurality of electrodes configured to manipulate droplets of fluid in a microfluidic space, each electrode being coupled to circuitry which applies driving voltages to the electrode; and a processing unit operably connected to a look up table correlating drive sequences to chemical species and at least one composition parameter. The processing unit is configured to: receive data of a first chemical species and a first composition parameter of the first composition; receive data of a second chemical species and a second composition parameter of the second composition; correlate a first drive sequence with the first chemical species and the first composition parameter; correlate a second drive sequence with the second chemical species and the second composition parameter; and output the first drive sequence and the second drive sequence to the electrodes.

Abstract: Devices, systems and methods are provided to treat damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc) by delivering specialized pulsed electric field (PEF) energy to target tissue areas. The energy is delivered in a manner so as to be non-thermal (i.e. below a threshold for causing thermal ablation). Consequently, when extracellular matrices present, the extracellular matrices are preserved, and the targeted tissue maintains its structural architecture including blood vessels and lymphatics. Thus, sensitive structures, such as biological lumens, blood vessels, nerves, etc, are preserved which are critical to maintaining the integrity and functionality of the tissue. The energy is delivered with the use of systems and devices advantageously designed for superior access to target tissue throughout the body, particularly in locations previously considered inaccessible to percutaneous approaches.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned communication over RF channels. In some implementations, information is obtained. An encoder network is used to process the information and generate a first RF signal. The first RF signal is transmitted through a first channel. A second RF signal is determined that represents the first RF signal having been altered by transmission through the first channel. Transmission of the first RF signal is simulated over a second channel implementing a machine-learning network, the second channel representing a model of the first channel. A simulated RF signal that represents the first RF signal having been altered by simulated transmission through the second channel is determined. A measure of distance between the second RF signal and the simulated RF signal is calculated. The machine-learning network is updated using the measure of distance.

Abstract: Treatment of damaged, diseased, abnormal, obstructive, cancerous or undesired tissue (e.g. a tumor, a benign tumor, a malignant tumor, a cyst, or an area of diseased tissue, etc.) is provided by delivering specialized pulsed electric field (PEF) energy to target tissue areas in a specific dose so as to obtain a superior outcome. The PEF energy and delivery has been optimized to provide advanced treatment of target tissue areas, including destruction of undesired tissue and generation of improved inflammatory and immune responses. These various types of treatment are controlled by a variety of factors including the electrode geometry, the dose of PEF energy delivered, the time the energy is delivered over, and the waveform of the PEF energy itself. The PEF energy is delivered in the form a dose which is considered to be one application of the specialized energy. Each dose creates a lesion in the target tissue area.

Abstract: Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.

Abstract: An electro-optic display including a first subpixel electrode and a second subpixel electrode associated with a display pixel, and an electrophoretic display medium disposed between a common electrode and the first and second subpixel electrodes. The electro-optic display also includes a display controller circuit in electrical communication with the common electrode and a first transistor associated with the display pixel. The display controller circuit is capable of applying waveforms to the display pixel by applying one or more time-dependent voltages between the common electrode and the first subpixel electrode via the first transistor, where the one or more time-dependent voltages are applied to the first subpixel electrode. The electro-optic display also includes a second transistor in electrical communication with the first subpixel electrode and the second subpixel electrode.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for adversarially generated communication. In some implementations, first information is used as input for a generator machine-learning network. Information is taken from both the generator machine-learning network and target information that includes sample signals or other data. The information is sent to a discriminator machine-learning network which produces decision information including whether the information originated from the generator machine-learning network or the target information. An optimizer takes the decision information and performs one or more iterative optimization techniques which help determine updates to the generator machine-learning network or the discriminator machine-learning network.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media for characterizing radio propagation channels. One method includes receiving, at a first modem, a first unit of communication over a radio frequency (RF) communication path from a second modem, wherein the first modem and the second modem process information for RF communications. The first modem identifies fields in the first unit of communication, the fields used to analyze the RF communication path. The first modem extracts data from the fields. The first modem accesses a channel model for approximating a channel representative of the RF communication path from the first modem to the second modem, wherein the channel model includes machine learning models. The first modem trains the channel model using the extracted data. The first modem applies the trained channel model to simulate a set of channel effects associated with the communication path.

Abstract: Devices, systems and methods are provided for treating of target tissue within a body of a patient, particularly tumors. Such systems can include an energy delivery device having at least one energy delivery body configured to be positioned near a target tissue area of the patient, and a generator in electrical communication with the at least one energy body. The generator can include at least one energy delivery algorithm configured to provide an electric signal of pulsed electric field energy deliverable to the at least one energy delivery body so as to induce extravasation within the target tissue area.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for training and deploying machine-learned communication over RF channels. In some implementations, information is obtained. An encoder network is used to process the information and generate a first RF signal. The first RF signal is transmitted through a first channel. A second RF signal is determined that represents the first RF signal having been altered by transmission through the first channel. Transmission of the first RF signal is simulated over a second channel implementing a machine-learning network, the second channel representing a model of the first channel. A simulated RF signal that represents the first RF signal having been altered by simulated transmission through the second channel is determined. A measure of distance between the second RF signal and the simulated RF signal is calculated. The machine-learning network is updated using the measure of distance.

Abstract: Methods and systems for distributing electrical energy to tissue which minimize Joule heating, thermal effects, and/or thermal damage, without sacrificing efficacy of treatment, are described. The methods and systems are particularly suitable to electrical energy-based therapies employing multiple electrodes, such as arrays of electrodes.

Abstract: A system and method for combining the inputs of various sensors used in platforms, primarily those having a military use, having or making use of a number of inputs capable of determining information about an environment in which they are operating. Each input is configured to output a standardized set of information regarding its capabilities and the environment in which it is operating. A correlator is configured to adaptably process the information based on rules contained in at least one changeable correlation matrix and information contained in at least one changeable configuration file. The information, or simply an alert, is provided to at least one output that provides the information to a human operator.

Abstract: Systems and methods for tracking entities and objects in an environment can include an entity-mounted instrumentation (EMI) and an object-mounted instrumentation (OMI). The OMI can include a first IMU array to detect the object orientation, and a TOF pulse transmitter to transmit a TOF pulse. The EMI can include a second IMU array to detect the entity orientation, a GPS receiver, and an array of TOF sensors to receive various versions of the TOF pulse. The EMI can determine a location and orientation of the entity using GPS data and orientation data generated by the second IMU array. The EMI can determine a relative location of the object using the various versions of the TOF pulse, and can determine a location of the object using the relative location of the object and the location of the entity. The EMI can determine the object orientation using data provided by the first IMU array.