Patents by Inventor Timothy J. Pelura
Timothy J. Pelura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8247370Abstract: The present invention relates to improved methods of treating fibrotic or fibroproliferative disorders. Conjoint therapies are provided comprising the combination of one or more fibrocyte suppressors and one or more profibrotic factor antagonists or anti-fibrotic agents.Type: GrantFiled: December 4, 2007Date of Patent: August 21, 2012Assignee: Promedior, Inc.Inventor: Timothy J. Pelura
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Publication number: 20100111898Abstract: The present invention relates to improved methods of treating fibrotic or fibroproliferative disorders. Conjoint therapies are provided comprising the combination of one or more fibrocyte suppressors and one or more profibrotic factor antagonists or anti-fibrotic agents.Type: ApplicationFiled: December 4, 2007Publication date: May 6, 2010Applicant: PROMEDIOR, INCInventor: Timothy J. Pelura
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Patent number: 6689756Abstract: Provided is, among other things, a method of treating in an animal infection or neoplasm of cerebrospinal tissue characterized by a risk of death, the method comprising: (a) injecting a physiologically acceptable fluid for cerebrospinal perfusion into a first catheter into the cerebrospinal pathway, which fluid for cerebrospinal perfusion has an therapeutically effective amount an agent, the agent selected for effectiveness against the infection as identified or diagnosed; (b) withdrawing fluid at a second catheter into the cerebrospinal pathway to create a flow and flow pathway between the first and second catheters; and (c) maintaining the flow for a period of time adapted to perfuse at least 1 CSF volume.Type: GrantFiled: March 4, 2002Date of Patent: February 10, 2004Assignee: Integra LifeSciences CorporationInventors: David P. Hesson, Timothy J. Pelura, Glen D. Frazer
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Publication number: 20030163181Abstract: Provided, among other things, is a method of treating, in an animal, an injury that is stroke, traumatic brain injury including traumatic surgical brain injury, brain hemorrhage other than stroke, spinal cord traumatic injury including spinal cord surgical trauma, infection, ischemia caused by surgical intervention, CNS injury caused by cardiac arrest, encephalitis or encephalomyelitis not due to infection, comprising: (a) creating a flow pathway, with an instillation catheter and an effluent catheter, that provides liquid flow in the vicinity of the injury; (b) instilling into the flow pathway an cerebrospinal perfusion fluid having a temperature from (i) 4° C. as a lower temperature to (ii) 4° C. below normal temperature of the animal; and (c) maintaining perfusion through the flow pathway for at least 12 hours of the cerebrospinal perfusion fluid having a temperature, at the point of instillation, from (i) 4° C. as a lower temperature to (ii) 4° C. below normal temperature of the animal.Type: ApplicationFiled: December 9, 2002Publication date: August 28, 2003Applicant: Neuron Therapeutics, Inc.Inventors: Glenn D. Frazer, David P. Hesson, Timothy J. Pelura, James C. Barnitz
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Publication number: 20030135196Abstract: Subarachnoid hemorrhage is treated by circulating a synthetic cerebrospinal fluid containing an emulsifying agent in the cerebrospinal fluid pathway in the vicinity of hemorrhage. The emulsifying agent scavenges blood products and circulation of the synthetic cerebrospinal fluid clears the blood products form the subarachnoid space to reduce cerebral vasospasm.Type: ApplicationFiled: August 28, 2002Publication date: July 17, 2003Applicant: Neuron Therapeutics, Inc.Inventors: David P. Hesson, Glen D. Frazer, Timothy J. Pelura, Barbara L. Powers, Bruce Shook
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Publication number: 20030060421Abstract: Provided, among other things, is a kit providing pre-measured amounts of components to form a fluorocarbon nutrient emulsion capable of carrying oxygen to living tissue, the kit comprising: constituent solutions, emulsions or particle compositions, which are the constituent compositions, containing pre-measured amounts of components for making the fluorocarbon nutrient emulsion, the constituent compositions comprising: poly-fluorinated, oxygen-carrying compound; a physiologically acceptable emulsifying agent effective to emulsify the polymer; a nutrient-providing effective amount of carbohydrate; nutrient-providing effective amounts of amino acids or amino acid precursors; an oncotic agent in amount effective to provide, in conjunction with the other components of the solution, a physiologically acceptable oncotic pressure; and sufficient salts and buffering agents to provide a physiological osmotic pressure and physiologically appropriate concentrations of potassium and sodium ions; wherein constituent compoType: ApplicationFiled: July 19, 2001Publication date: March 27, 2003Applicant: Neuron Therapeutics, Inc.Inventors: David P. Hesson, Glenn David Frazer, Timothy J. Pelura
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Publication number: 20030022879Abstract: Provided is, among other things, a method of treating in an animal infection or neoplasm of cerebrospinal tissue characterized by a risk of death, the method comprising: (a) injecting a physiologically acceptable fluid for cerebrospinal perfusion into a first catheter into the cerebrospinal pathway, which fluid for cerebrospinal perfusion has an therapeutically effective amount an agent, the agent selected for effectiveness against the infection as identified or diagnosed; (b) withdrawing fluid at a second catheter into the cerebrospinal pathway to create a flow and flow pathway between the first and second catheters; and (c) maintaining the flow for a period of time adapted to perfuse at least 1 CSF volume.Type: ApplicationFiled: March 4, 2002Publication date: January 30, 2003Inventors: David P. Hesson, Timothy J. Pelura, Glen D. Frazer
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Patent number: 5635538Abstract: A fluorocarbon emulsion which exhibits reduced pulmonary gas-trapping properties in species-sensitive laboratory animals is disclosed. Additionally, the fluorocarbon component(s) exhibit short organ retention time(s). The emulsion includes an aqueous phase, an emulsifier, and a fluorocarbon (or fluorocarbon composition), having a vapor pressure of less than about 8 torr to reduce pulmonary gas-trapping, and having an organ retention half life of less than about 6 weeks and more preferably less than about 3 to 4 weeks.Type: GrantFiled: March 16, 1993Date of Patent: June 3, 1997Assignee: Alliance Pharmaceutical Corp.Inventors: Jeffry G. Weers, Ernest G. Schutt, Timothy J. Pelura, Peter E. Keipert
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Patent number: 5023100Abstract: An edible fish oil is disclosed which contains EPA and DHA. This oil, with significantly reduced undesirable impurities, is obtained by subjecting fish oil to vacuum steam distillation contacting the oil with an adsorbent and recovering the oil. The oil can be combined with a vegetable oil and/or Rosemary extract antioxidant to improve its oxidative stability.Type: GrantFiled: October 2, 1989Date of Patent: June 11, 1991Assignee: Kabi Vitrum ABInventors: Stephen S. Chang, Yongde Bao, Timothy J. Pelura
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Patent number: 4874629Abstract: A process of treating oils containing Omega-3 fatty acids, such as fish oils like Menhaden oil, sardine oil, salmon oil and other oils, to produce odorless and flavorless oils which contain only insignificant amounts of undesirable minor constituents, such as thermal and oxidative polymers of unsaturated glycerides, trans-isomers, positional isomers, conjugated dienes and trienes, cholesterols, pesticides, PCBs and heavy metals, and which have reasonably good flavor and oxidative stabilities.Type: GrantFiled: May 2, 1988Date of Patent: October 17, 1989Inventors: Stephen S. Chang, Yongde Bao, Timothy J. Pelura