Abstract: Pyrrolidine main protease inhibitors are described that are effective as antiviral compounds.

Abstract: The present invention relates to a method and apparatus for splicing a web of layered material so that a new roll of material may be joined to an expiring web via a butt joint. A shear wheel is driven to ensure that the shear wheel positively rotates as it cuts across web material that is held against the side of an anvil. In the illustrated embodiment, a drive cable and shear wheel assembly are operably connected to a splicing apparatus, a portion of the drive cable being threaded through the splicing apparatus and wrapped around at least a portion of the shear wheel, the threaded drive cable being maintained under tension. The rapid movement of the shear wheel assembly, and the wrapping engagement between the taut threaded drive cable and shear wheel, forces the shear wheel to positively spin, thereby improving the cutting capabilities of the attached rotary cutter.

Abstract: The present invention relates to a method and apparatus for splicing a web of layered material so that a new roll of material may be joined to an expiring web via a butt joint. A shear wheel is driven to ensure that the shear wheel positively rotates as it cuts across web material that is held against the side of an anvil. In the illustrated embodiment, a drive cable and shear wheel assembly are operably connected to a splicing apparatus, a portion of the drive cable being threaded through the splicing apparatus and wrapped around at least a portion of the shear wheel, the threaded drive cable being maintained under tension. The rapid movement of the shear wheel assembly, and the wrapping engagement between the taut threaded drive cable and shear wheel, forces the shear wheel to positively spin, thereby improving the cutting capabilities of the attached rotary cutter.

Abstract: A method and system for preventing damage to a movable dancer assembly in a festoon upon the breakage of the running web that runs through the festoon. During normal running of the web, the vertical position of the dancer assembly, in the festoon and vis-à-vis the fixed entry and exit idlers of the festoon, is controlled by a dancer tensioning cylinder assembly that includes a cylinder and a piston which is connected with the dancer assembly and which is movable in the cylinder in response to pressurized air in a first portion of the cylinder and applied to a first surface of the piston. Upon the breaking of the running web, air pressure is permitted to increase in a second portion of the cylinder and is applied to the second, opposite surface of the piston until the pressure of the air in the first and second positions becomes equal. After a preselected delay after the running web breaks, the pressurized air in the first and second portions of the cylinder is bled from the cylinder.

Abstract: A method and web splicing assembly for heat-seal splicing together a trailing end of running first, two-sided plastic material web and a leading end of a second, two-sided plastic material web, and then for heat-seal splicing together a leading end of third, two-side plastic material web and the trailing of the then running, second web so that after the webs have been spliced and are running, like surfaces of the webs face the same direction. The web splicing assembly includes first and second splicing sub-assemblies. The first sub-assembly has a first, relatively movable slide bar and a first, relatively fixed nip bar. The second sub-assembly has a second, relatively movable slide bar and a second, relatively fixed nip bar. The sub-assemblies are each movable between a first position and a second position. In their first positions, the sub-assemblies are disposed so that portions of the webs to be heat-seal spliced are clamped between the first slide bar and the second nip bar.