Abstract: An apparatus and method are provided for collection and analysis of dry powder inhaler products to determine foreign particulate matter found therein. The apparatus includes a collection chamber that communicates directly with the mouthpiece of a dry powder inhaler device. The collection chamber is used to both collect product samples, as well as to mix the samples with a diluent that places the active pharmaceutical components and excipients in solution, while the foreign particulate matter remains suspended. Analysis of a sample is preferably conducted by light obscuration wherein a probe is inserted directly within the collection chamber of the apparatus. An integral magnetic stir-bar incorporated within the apparatus eliminates the need to transfer the collected sample to a secondary vessel for mixing or analysis.

Abstract: An apparatus and method are provided for collection and analysis of dry powder inhaler products to determine foreign particulate matter found therein. The apparatus includes a collection chamber that communicates directly with the mouthpiece of a dry powder inhaler device. The collection chamber is used to both collect product samples, as well as to mix the samples with a diluent that places the active pharmaceutical components and excipients in solution, while the foreign particulate matter remains suspended. Analysis of a sample is preferably conducted by light obscuration wherein a probe is inserted directly within the collection chamber of the apparatus. An integral magnetic stir-bar incorporated within the apparatus eliminates the need to transfer the collected sample to a secondary vessel for mixing or analysis.