Abstract: Compounds of Formula (I): pharmaceutically acceptable salts thereof, deuterated derivatives of any of the foregoing, and metabolites of any of the foregoing are disclosed. Pharmaceutical compositions comprising the same, methods of treating cystic fibrosis using the same, and methods for making the same are also disclosed.

Abstract: The Tie-Line-Attendant (“TLA”) identifies a distressed animal and alarms its owner for immediate assistance. The TLA Transmitter is connected between the tie line and the tether line. The owner sets the maximum time duration (“MTD”) allowed for an animal to exert pressure on the tether line. When an animal exerts pressure on the tether line, the tether line and tie line will pull the TLA eyelets closing the normally open contacts. A timer will count the duration of the pressure. If the pressure is released before MTD is reached, the timer will reset itself automatically. Otherwise, the transmitter will sound an alarm and send a signal to the owner's receiver. The receiver will then alarm the owner that his animal needs immediate assistance. The transmitter and the receiver contain: control switches, LED indicators, and an audible alarm.