Patents by Inventor Timothy Keane
Timothy Keane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11389566Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: GrantFiled: March 14, 2017Date of Patent: July 19, 2022Assignees: Regentys Corporation, University of Pittsburgh—of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20210093751Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration extracellular matrix hydrogel (ECMH) which stimulates stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: July 7, 2020Publication date: April 1, 2021Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20190076574Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: March 14, 2017Publication date: March 14, 2019Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20170112964Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: November 3, 2016Publication date: April 27, 2017Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20160045552Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.Type: ApplicationFiled: April 8, 2014Publication date: February 18, 2016Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher EducationInventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
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Publication number: 20040097549Abstract: Food compositions comprising at least one cyclooxygenase-2 inhibitor, methods for the treatment or prophylaxis of a condition or disorder in a non-human where administration of a cyclooxygenase-2 inhibitor is indicated comprising feeding such food compositions to the non-human, articles of manufacture comprising such food compositions, and methods for the preparation of food compositions comprising a cyclooxygenase-2 inhibitor.Type: ApplicationFiled: November 6, 2003Publication date: May 20, 2004Applicant: Pharmacia CorporationInventors: J. Timothy Keane, Joseph R. Schuh, Alan L. Scrivner
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Patent number: 6701700Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is attached through suitable structure to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.Type: GrantFiled: August 19, 2002Date of Patent: March 9, 2004Inventor: Stephen Timothy Keane
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Patent number: 6691792Abstract: An edger attachment apparatus is provided for attaching to a drive-shaft-to-attachment coupling of a string trimmer device after the string trimmer head has been detached from the drive-shaft-to-attachment coupling. A relatively small diameter, power transmission driving gear is driven by an edger driven shaft. A relatively large diameter, power receiver gear is driven by the relatively small diameter, power transmission driving gear. A blade assembly drive shaft is connected to the relatively large diameter, power receiver gear. An edger blade assembly is driven by the blade assembly drive shaft. A wheel assembly support is attached to the gear housing, and a wheel assembly is connected to the wheel assembly support. In one embodiment, a height adjustment assembly is provided. In another embodiment, a tilt adjustment assembly is provided. In another embodiment, both a height adjustment assembly and a tilt adjustment assembly are provided.Type: GrantFiled: May 17, 2002Date of Patent: February 17, 2004Inventor: Stephen Timothy Keane
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Publication number: 20030070408Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is attached through suitable means to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.Type: ApplicationFiled: August 19, 2002Publication date: April 17, 2003Inventor: Stephen Timothy Keane
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Publication number: 20030047329Abstract: An edger attachment apparatus is provided for attaching to a drive-shaft-to-attachment coupling of a string trimmer device after the string trimmer head has been detached from the drive-shaft-to-attachment coupling. A relatively small diameter, power transmission driving gear is driven by an edger driven shaft. A relatively large diameter, power receiver gear is driven by the relatively small diameter, power transmission driving gear. A blade assembly drive shaft is connected to the relatively large diameter, power receiver gear. An edger blade assembly is driven by the blade assembly drive shaft. A wheel assembly support is attached to the gear housing, and a wheel assembly is connected to the wheel assembly support. In one embodiment, a height adjustment assembly is provided. In another embodiment, a tilt adjustment assembly is provided. In another embodiment, both a height adjustment assembly and a tilt adjustment assembly are provided.Type: ApplicationFiled: May 17, 2002Publication date: March 13, 2003Inventor: Stephen Timothy Keane
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Patent number: 6434920Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable suitably is attached to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.Type: GrantFiled: July 10, 2000Date of Patent: August 20, 2002Inventor: Stephen Timothy Keane
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Patent number: 6281235Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful as renin inhibitors for the treatment of a renin-mediated disease Compounds of particular interest are those of Formula I wherein A is selected from CO and SO2; wherein X is selected from oxygen atom and methylene; wherein each of R1 and R9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, &bgr;,&bgr;&bgr;-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R1 and R9 are attached may be combined with oxygen to form an N-oxide; wherein R2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R5 is selected from hydrido, alkyl, pyrazolealkyl, pyridylalkyl, thiazolylalkyl, imidazolealkyl, thienylalkyl, furanylalkyl, oxazolylalkyl, isoxazolylalkyl, pyrimidinylalkyl, pyridazinylalkyl and pyraziType: GrantFiled: May 24, 1999Date of Patent: August 28, 2001Assignee: G.D. Searle & Co.Inventors: Gunnar J. Hanson, J. Timothy Keane
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Patent number: 6085507Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is suitably attached to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.Type: GrantFiled: January 11, 1999Date of Patent: July 11, 2000Inventor: Stephen Timothy Keane
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Patent number: 5862595Abstract: A hand-holdable trimmer for garden and lawn applications has an elongated housing defining an air passage extending from the trimmer's rotating trimmer head to a collection container for cuttings mounted distally on the housing. An impeller wheel driven by the trimmer motor causes air to flow under positive pressure from the region surrounding the trimmer head through the housing air passage to eventually deliver the trimmer cuttings to the collection container. A dual, axially adjustable trimmer head assembly also is provided to more efficiently cut grass, weeds, etc. into small pieces capable of being easily transferred to the collection container.Type: GrantFiled: November 7, 1996Date of Patent: January 26, 1999Inventor: Stephen Timothy Keane
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Patent number: 5857315Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is attached to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.Type: GrantFiled: September 25, 1996Date of Patent: January 12, 1999Inventor: Stephen Timothy Keane
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Patent number: 5849773Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein each of R.sub.1 and R.sub.9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, .beta.,.beta.,.beta.-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R.sub.1 and R.sub.9 are attached may be combined with oxygen to form an N-oxide; wherein R.sub.2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R.sub.3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R.sub.Type: GrantFiled: June 14, 1996Date of Patent: December 15, 1998Assignee: G. D. Searle & Co.Inventors: Gunnar J. Hanson, J. Timothy Keane
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Patent number: 5508295Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful in treatment of glaucoma. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein each of R.sub.1 and R.sub.9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, b,b,b-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R.sub.1 and R.sub.9 are attached may be combined with oxygen to form an N-oxide; wherein R.sub.2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R.sub.3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R.sub.Type: GrantFiled: January 13, 1994Date of Patent: April 16, 1996Assignee: G. D. Searle & Co.Inventors: Gunnar J. Hanson, J. Timothy Keane
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Patent number: 5330996Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein each of R.sub.1 and R.sub.9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, .beta.,.beta.,.beta.-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R.sub.1 and R.sub.9 are attached may be combined with oxygen to form an N-oxide; wherein R.sub.2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R.sub.3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R.sub.Type: GrantFiled: October 29, 1991Date of Patent: July 19, 1994Assignee: G. D. Searle & Co.Inventors: Gunnar J. Hanson, J. Timothy Keane