Patents by Inventor Timothy Keane

Timothy Keane has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11389566
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: July 19, 2022
    Assignees: Regentys Corporation, University of Pittsburgh—of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20210093751
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration extracellular matrix hydrogel (ECMH) which stimulates stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: July 7, 2020
    Publication date: April 1, 2021
    Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20190076574
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: March 14, 2017
    Publication date: March 14, 2019
    Applicants: Regentys Corporation, University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20170112964
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: November 3, 2016
    Publication date: April 27, 2017
    Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20160045552
    Abstract: Methods and compositions for treating diseased or damaged tissue, such as Inflammatory Bowel Disease, e.g., Ulcerative Colitis, include tissue regeneration using stem cells or tissue grafts which stimulate stem cell migration to the damaged tissue. The tissue grafts can be extracellular matrix (ECM) material, such as tissue-specific extracellular matrix (TS-ECM). The methods can also include mucosal resection of the damaged or diseased tissue prior to placement of the graft.
    Type: Application
    Filed: April 8, 2014
    Publication date: February 18, 2016
    Applicants: Asana Medical, Inc., University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Marc Ramer, Stephen F. Badylak, Timothy Keane
  • Publication number: 20040097549
    Abstract: Food compositions comprising at least one cyclooxygenase-2 inhibitor, methods for the treatment or prophylaxis of a condition or disorder in a non-human where administration of a cyclooxygenase-2 inhibitor is indicated comprising feeding such food compositions to the non-human, articles of manufacture comprising such food compositions, and methods for the preparation of food compositions comprising a cyclooxygenase-2 inhibitor.
    Type: Application
    Filed: November 6, 2003
    Publication date: May 20, 2004
    Applicant: Pharmacia Corporation
    Inventors: J. Timothy Keane, Joseph R. Schuh, Alan L. Scrivner
  • Patent number: 6701700
    Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is attached through suitable structure to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.
    Type: Grant
    Filed: August 19, 2002
    Date of Patent: March 9, 2004
    Inventor: Stephen Timothy Keane
  • Patent number: 6691792
    Abstract: An edger attachment apparatus is provided for attaching to a drive-shaft-to-attachment coupling of a string trimmer device after the string trimmer head has been detached from the drive-shaft-to-attachment coupling. A relatively small diameter, power transmission driving gear is driven by an edger driven shaft. A relatively large diameter, power receiver gear is driven by the relatively small diameter, power transmission driving gear. A blade assembly drive shaft is connected to the relatively large diameter, power receiver gear. An edger blade assembly is driven by the blade assembly drive shaft. A wheel assembly support is attached to the gear housing, and a wheel assembly is connected to the wheel assembly support. In one embodiment, a height adjustment assembly is provided. In another embodiment, a tilt adjustment assembly is provided. In another embodiment, both a height adjustment assembly and a tilt adjustment assembly are provided.
    Type: Grant
    Filed: May 17, 2002
    Date of Patent: February 17, 2004
    Inventor: Stephen Timothy Keane
  • Publication number: 20030070408
    Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is attached through suitable means to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.
    Type: Application
    Filed: August 19, 2002
    Publication date: April 17, 2003
    Inventor: Stephen Timothy Keane
  • Publication number: 20030047329
    Abstract: An edger attachment apparatus is provided for attaching to a drive-shaft-to-attachment coupling of a string trimmer device after the string trimmer head has been detached from the drive-shaft-to-attachment coupling. A relatively small diameter, power transmission driving gear is driven by an edger driven shaft. A relatively large diameter, power receiver gear is driven by the relatively small diameter, power transmission driving gear. A blade assembly drive shaft is connected to the relatively large diameter, power receiver gear. An edger blade assembly is driven by the blade assembly drive shaft. A wheel assembly support is attached to the gear housing, and a wheel assembly is connected to the wheel assembly support. In one embodiment, a height adjustment assembly is provided. In another embodiment, a tilt adjustment assembly is provided. In another embodiment, both a height adjustment assembly and a tilt adjustment assembly are provided.
    Type: Application
    Filed: May 17, 2002
    Publication date: March 13, 2003
    Inventor: Stephen Timothy Keane
  • Patent number: 6434920
    Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable suitably is attached to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: August 20, 2002
    Inventor: Stephen Timothy Keane
  • Patent number: 6281235
    Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful as renin inhibitors for the treatment of a renin-mediated disease Compounds of particular interest are those of Formula I wherein A is selected from CO and SO2; wherein X is selected from oxygen atom and methylene; wherein each of R1 and R9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, &bgr;,&bgr;&bgr;-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R1 and R9 are attached may be combined with oxygen to form an N-oxide; wherein R2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R5 is selected from hydrido, alkyl, pyrazolealkyl, pyridylalkyl, thiazolylalkyl, imidazolealkyl, thienylalkyl, furanylalkyl, oxazolylalkyl, isoxazolylalkyl, pyrimidinylalkyl, pyridazinylalkyl and pyrazi
    Type: Grant
    Filed: May 24, 1999
    Date of Patent: August 28, 2001
    Assignee: G.D. Searle & Co.
    Inventors: Gunnar J. Hanson, J. Timothy Keane
  • Patent number: 6085507
    Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is suitably attached to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: July 11, 2000
    Inventor: Stephen Timothy Keane
  • Patent number: 5862595
    Abstract: A hand-holdable trimmer for garden and lawn applications has an elongated housing defining an air passage extending from the trimmer's rotating trimmer head to a collection container for cuttings mounted distally on the housing. An impeller wheel driven by the trimmer motor causes air to flow under positive pressure from the region surrounding the trimmer head through the housing air passage to eventually deliver the trimmer cuttings to the collection container. A dual, axially adjustable trimmer head assembly also is provided to more efficiently cut grass, weeds, etc. into small pieces capable of being easily transferred to the collection container.
    Type: Grant
    Filed: November 7, 1996
    Date of Patent: January 26, 1999
    Inventor: Stephen Timothy Keane
  • Patent number: 5857315
    Abstract: An auxiliary edge trimmer apparatus is attached to a lawnmower and includes a flywheel drive wheel portion connected to the lawnmower drive shaft. An attachment assembly is connected onto portions of the lower housing wall of the blade housing of the lawnmower. A trimmer assembly is attached to the attachment assembly and includes a bearing portion connected to the attachment assembly, a rotatable shaft assembly received by the bearing portion, a driven wheel connected to a proximal end of the rotatable shaft assembly, and a trimmer blade connected to a distal end of the rotatable shaft assembly. In accordance with an alternatively preferred embodiment of the invention, a manually actuatable control cable is attached to the drive shaft supported on the lawnmower housing between the drive wheel and the auxiliary trimmer apparatus to control engagement and disengagement thereof.
    Type: Grant
    Filed: September 25, 1996
    Date of Patent: January 12, 1999
    Inventor: Stephen Timothy Keane
  • Patent number: 5849773
    Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein each of R.sub.1 and R.sub.9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, .beta.,.beta.,.beta.-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R.sub.1 and R.sub.9 are attached may be combined with oxygen to form an N-oxide; wherein R.sub.2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R.sub.3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R.sub.
    Type: Grant
    Filed: June 14, 1996
    Date of Patent: December 15, 1998
    Assignee: G. D. Searle & Co.
    Inventors: Gunnar J. Hanson, J. Timothy Keane
  • Patent number: 5508295
    Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful in treatment of glaucoma. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein each of R.sub.1 and R.sub.9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, b,b,b-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R.sub.1 and R.sub.9 are attached may be combined with oxygen to form an N-oxide; wherein R.sub.2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R.sub.3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R.sub.
    Type: Grant
    Filed: January 13, 1994
    Date of Patent: April 16, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Gunnar J. Hanson, J. Timothy Keane
  • Patent number: 5330996
    Abstract: Compounds characterized generally as amino acyl amino propargyl diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein each of R.sub.1 and R.sub.9 is a group independently selected from hydrido, methyl, ethyl, n-propyl, isopropyl, benzyl, .beta.,.beta.,.beta.-trifluoroethyl, t-butyloxycarbonyl and methoxymethylcarbonyl, and wherein the nitrogen atom to which R.sub.1 and R.sub.9 are attached may be combined with oxygen to form an N-oxide; wherein R.sub.2 is selected from hydrido, methyl, ethyl and isopropyl; wherein R.sub.3 is selected from benzyl, cyclohexylmethyl, phenethyl, imidazolemethyl, pyridylmethyl and 2-pyridylethyl; wherein R.sub.
    Type: Grant
    Filed: October 29, 1991
    Date of Patent: July 19, 1994
    Assignee: G. D. Searle & Co.
    Inventors: Gunnar J. Hanson, J. Timothy Keane