Patents by Inventor Timothy M. Wiles
Timothy M. Wiles has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11840719Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: July 13, 2020Date of Patent: December 12, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Publication number: 20230383232Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: ApplicationFiled: May 3, 2023Publication date: November 30, 2023Applicant: BD KIESTRA B.V.Inventors: Timothy M. Wiles, Raphael R. Marcelpoil
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Publication number: 20230360415Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.Type: ApplicationFiled: June 27, 2023Publication date: November 9, 2023Applicant: BECTON, DICKINSON AND COMPANYInventors: Michael A. Brasch, Curtis M. Gosnell, Timothy M. Wiles, Raphael Rodolphe Marcelpoil, Bas Nieuwenhuis, Trienko Marten Van Der Kaap, Michael Bois
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Patent number: 11727699Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.Type: GrantFiled: October 4, 2018Date of Patent: August 15, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Michael A. Brasch, Curtis M. Gosnell, Timothy M. Wiles, Raphael Rodolphe Marcelpoil, Bas Nieuwenhuis, Trienko Marten Van Der Kaap, Michael Bois
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Patent number: 11674116Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: GrantFiled: May 18, 2020Date of Patent: June 13, 2023Assignee: BD KIESTRA B.V.Inventors: Timothy M. Wiles, Raphael R. Marcelpoil
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Patent number: 11669971Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: GrantFiled: April 29, 2022Date of Patent: June 6, 2023Assignee: BD KIESTRA B.V.Inventors: Timothy M. Wiles, Raphael Rodolphe Marcelpoil
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Publication number: 20220383498Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: ApplicationFiled: April 29, 2022Publication date: December 1, 2022Applicant: BD KIESTRA B.V.Inventors: Timothy M. Wiles, Raphael Rodolphe Marcelpoll
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Patent number: 11341648Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: GrantFiled: May 15, 2020Date of Patent: May 24, 2022Assignee: Timothy M. WilesInventors: Timothy M. Wiles, Raphael Rodolphe Marcelpoil
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Publication number: 20210199546Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.Type: ApplicationFiled: June 24, 2019Publication date: July 1, 2021Applicant: BD KIESTRA B.V.Inventors: Timothy Roy Hansen, Martijn Kleefstra, Michael Bois, Timothy M. Wiles, Charles Chak Cheung Yu
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Patent number: 10921336Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.Type: GrantFiled: May 27, 2016Date of Patent: February 16, 2021Assignee: BD KIESTRA B.V.Inventors: Timothy Roy Hansen, Rick Holtz, Martijn Kleefstra, Raphael R. Marcelpoil, Rick Pierpont, Brent Ronald Pohl, Alyssa Shedlosky, Scott Shindledecker, Edward Skevington, Kerry Lynn Smith, Timothy M. Wiles
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Publication number: 20200340029Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: July 13, 2020Publication date: October 29, 2020Inventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Publication number: 20200342604Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: ApplicationFiled: May 15, 2020Publication date: October 29, 2020Inventors: Timothy M. Wiles, Raphael Rodolphe Marcelpoil
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Publication number: 20200283719Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: ApplicationFiled: May 18, 2020Publication date: September 10, 2020Inventors: Timothy M. Wiles, Raphael R. Marcelpoil
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Patent number: 10767146Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: October 24, 2014Date of Patent: September 8, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Eric Ursprung, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Publication number: 20200242329Abstract: A system and method for developing applications (Apps) for automated assessment and analysis of processed biological samples. Such samples are obtained, combined with nutrient media and incubated. The incubated samples are imaged and the image information is classified according to predetermined criteria. The classified image information is then evaluated according to Apps derived from classified historical image information in a data base. The classified historical image information is compared with the classified image information to provide guidance on further processing of the biological sample through Apps tailored to process provide sample process guidance tailored to the classifications assigned to the image information.Type: ApplicationFiled: October 4, 2018Publication date: July 30, 2020Applicant: BECTON DICKINSON AND COMPANYInventors: Michael A. Brasch, Curtis M. Gosnell, Timothy M. Wiles, Raphael Rodolphe Marcelpoil, Bas Nieuwenhuis, Trienko Marten Van Der Kaap, Michael Bois
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Patent number: 10696938Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: GrantFiled: April 22, 2016Date of Patent: June 30, 2020Assignee: BD KIESTRA B. V.Inventors: Timothy M. Wiles, Raphael R. Marcelpoil
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Patent number: 10692216Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: GrantFiled: November 12, 2019Date of Patent: June 23, 2020Assignee: BD KIESTRA B.V.Inventors: Timothy M. Wiles, Raphael Rodolphe Marcelpoil
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Publication number: 20200090335Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: ApplicationFiled: November 12, 2019Publication date: March 19, 2020Inventors: Timothy M. Wiles, Raphael Rodolphe Marcelpoil
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Publication number: 20180284146Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.Type: ApplicationFiled: May 27, 2016Publication date: October 4, 2018Applicant: B.D. KIESTRA B.V.Inventors: Timothy Roy Hansen, Rick Holtz, Martijn Kleefstra, Raphael R. Marcelpoil, Rick Pierpont, Brent Ronald Pohl, Alyssa Shediosky, Scott Shindledecker, Edward Skevington, Kerry Lynn Smith, Timothy M. Wiles
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Publication number: 20180112173Abstract: An imaging system and method for microbial growth detection, counting or identification. One colony may be contrasted in an image that is not optimal for another type of colony. The system and method provides contrast from all available material through space (spatial differences), time (differences appearing over time for a given capture condition) and color space transformation using image input information over time to assess whether microbial growth has occurred for a given sample.Type: ApplicationFiled: April 22, 2016Publication date: April 26, 2018Applicant: BD KIESTRA B.V.Inventors: TIMOTHY M WILES, Raphael R. Marcelpoil