Abstract: Described herein are compounds that are inhibitors of autophagy and their use in the treatment of disorders such as cancers.

Abstract: Methods, apparatus, systems and articles of manufacture are disclosed for allocation in a victim cache system. An example apparatus includes a first cache storage, a second cache storage, a cache controller coupled to the first cache storage and the second cache storage and operable to receive a memory operation that specifies an address, determine, based on the address, that the memory operation evicts a first set of data from the first cache storage, determine that the first set of data is unmodified relative to an extended memory, and cause the first set of data to be stored in the second cache storage.

Abstract: Systems and methods for using stratigraphic heat maps to steer a well being drilled. Data from one or more offset wells can be provided to a computer system and used with data from a well being drilled to generate one or more stratigraphic heat maps during the drilling of the subject well. The stratigraphic heat maps can be displayed and used to determine the location of the wellbore relative to one or more geological formations, including one or more target formations or within a target formation. Based on the use of the heat maps and the location of the wellbore relative to a target, the drill plan can be adjusted or updated and/or one or more drilling parameters or operations may be adjusted to drill the wellbore, such as to drill the wellbore to the target or to maximize the length of the wellbore within a target zone.

Abstract: A head unit device for controlling motion of an object includes a chamber filled with a shear thickening fluid (STF) and a piston. The piston is housed within the chamber and exerts pressure against the STF from a force applied to the piston from the object. The STF is configured to have a decreasing viscosity in response to a first range of shear rates and an increasing viscosity in response to a second range of shear rates. The piston includes at least one piston bypass between opposite sides of the piston that controls flow of the STF between the opposite sides of the piston to selectively react with a shear threshold effect of the first range of shear rates or the second range of shear rates.

Abstract: An in-situ bollard tester. The in-situ bollard tester may comprise: a frame, cable, and tensioner. The frame is preferably adapted to mount onto a pier or wharf and around a bollard to provide structural support for the cable and tensioner. The frame may comprise a rectangular frame, pair of hanging columns, pair of jacks and pair of legs. The pair of jacks are coupled near proximal corners of the rectangular frame and are vertically disposed. The hanging columns are coupled near distal corners of the rectangular frame. The pair of legs are coupled at the lower ends of the hanging columns and are disposed in a horizontal manner. The tensioner may be coupled above the rectangular frame. The cable may fasten to the bollard, and the tensioner may apply tension to the cable at various load angles in order to test the integrity of the bollard.

Abstract: Systems and methods of repairing tissue are disclosed. Systems and methods may repair an opening through a hip capsule. Systems and methods preferably repair the tissue while minimally encroaching on the tissue immediately behind the repair, such as the hip joint tissues. Some systems may repair the tissue with a suture passer having a needle that slides in axial alignment with the passer and includes a first recess for passing the suture in a first axial direction and a second recess for passing the suture in an opposing axial direction. Some systems may pass a portion of a repair construct in a retrograde direction, placing the repair construct in a preferred arrangement accommodating for the stresses on the tissue.

Abstract: A control system and methods for controlling the position of one or more engine-mounting links of an engine-mounting linkage system are provided. In one aspect, an engine-mounting linkage system includes one or more engine-mounting links that each have an adjustable inclination angle. An inclination angle of a link may be adjusted by an actuator of the control system. One or more controllers of the control system can control the actuator and thus the inclination angle of the link by determining a control command based at least in part on an output received from one or more sensors of the control system. The controllers can then cause the actuator to change the inclination angle of the link based at least in part on the determined control command.

Abstract: A fluidic device, instrument, and method for processing a biological sample is disclosed herein. An example of the fluidic device includes structures (e.g., sample holder(s), reaction chamber(s), reagent storage zone(s), metering compartment(s), reaction well(s), detection well(s), channel(s), etc.) for efficiently processing sample components and providing expression levels of various biomarker components for characterization of a sample.

Abstract: A laminate includes a first glass article having a first thickness, a first annealing point (TA1), and a first softening point (TS1), a second glass article having a second thickness, a second annealing point (TA2), and a second softening point (TS2), and an interlayer disposed between the first glass article and the second glass article. The first thickness is greater than the second thickness, the second annealing point (TA2) is less than or equal to the first annealing point (TA1), and the second softening point (TS2) is greater than the first softening point (TS1).

Abstract: A method of fabricating a multilayer circuit board is provided which includes forming a layer of a the multilayer circuit board with an internal clearance region having a modified voltage-to-ground clearance of conductive material adjacent to an aperture of the multilayer circuit board. The modified voltage-to-ground clearance of conductive material is based on a configuration of a connector pin to be press-fit connected within the aperture of the multilayer circuit board, and the internal clearance region is enlarged in a direction of greatest normal force outward from the aperture with insertion of the connector pin into the aperture.

Abstract: Embodiments of a vehicle interior system are disclosed. In one or more embodiments, the system includes a base with a curved surface, and a display or touch panel disposed on the curved surface. The display includes a cold-bent glass substrate with a thickness of 1.5 mm or less and a first radius of curvature of 20 mm or greater, and a display module and/or touch panel attached to the glass substrate having a second radius of curvature that is within 10% of the first radius of curvature. Methods for forming such systems are also disclosed.

Abstract: The present document describes an electronic device with a structural midframe and associated methods. The architectural design of the electronic device (e.g., a security camera) is such that its components are assembled onto the midframe to form a subassembly and the housing is assembled after the subassembly. The midframe includes various features that enable multiple printed circuit boards, a camera subassembly, a front housing member, a heatsink, and a heat spreader to be assembled onto the midframe outside of the housing. The midframe can also include a hinge-bearing surface forming a portion of a ball joint for supporting rotational movement of the electronic device. Accordingly, the electronic device uses the midframe, rather than the housing, as a structural member.

Abstract: Foldable apparatus comprise a foldable substrate comprising a substrate thickness. The second major surface of the foldable substrate faces an end portion of a first inner surface area of a first housing member extending along a first plane. The second surface faces an end portion of a second inner surface area of a second housing member extending along a second plane. A support is attached to at least the second housing member. The support contacts the second major surface when an angle between the first plane and the second plane ranges from about 80° to about 135°. The support is spaced from the second major surface when an angle between the first plane and the second plane ranges from about 0° to about 30°. In some embodiments, the foldable substrate comprises a neutral stress configuration at a parallel plate distance ranging from about 20 millimeters to about 200 millimeters.

Abstract: A trim attachment system includes a light fixture housing and a first coiled spring bracket having a first coil section and a first elongated section. The first elongated section is positioned in the light fixture housing and attached to the light fixture housing, where the first coil section is attachable to a trim to pull up the trim toward an opening of the housing. The trim attachment system further includes a second coiled spring bracket having a second coil section and a second elongated section. The second elongated section is positioned in the light fixture housing and attached to the light fixture housing, where the second coil section is attachable to the trim to pull up the trim toward the opening of the housing.

Abstract: A system for labor scheduling and jobsite management is disclosed that manages a dynamically changing workforce. The system includes a graphical user interface (GUI) and a processor circuit that controls the GUI. The system provides a plurality of user-selectable input screens that allow input of information regarding employee onboarding, flexible staffing and workflow management, time entry/payroll support, significant event reporting, and medical protocol management. The system receives user input from one or more of the user-selectable input screens and generates, and dynamically updates, a plurality of work schedules for a respective plurality of workers having different skills working on different aspects of a job at different times as the job progresses.

Abstract: A materialization configuration request is received via a programmatic interface from a client of a journal-based multi-data-store database. The request indicates a partitioning rule to be used to select, for respective writes indicated in committed transaction entries of a journal, the materialization node at which the writes are to be stored. A control plane component of the database verifies that a set of materialization nodes corresponding to the partitioning rule has been established, and initiates the propagation of writes from the journal to the materialization nodes by respective write appliers.

Abstract: A method comprises measuring a light intensity at a window; determining if the light intensity exceeds a cloudy-day threshold; operating in a sunlight penetration limiting mode to control the motorized window treatment to control the sunlight penetration distance in the space; enabling the sunlight penetration limiting mode if the light intensity is greater than the cloudy-day threshold; and disabling the sunlight penetration limiting mode if the total lighting intensity is less than the cloudy-day threshold. The cloudy-day threshold is maintained at a constant threshold if a calculated solar elevation angle is greater than a predetermined solar elevation angle, and the cloudy-day threshold varies with time if the calculated solar elevation angle is less than the predetermined solar elevation angle. The cloudy-day threshold is a function of the calculated solar elevation angle if the calculated solar elevation angle is less than the predetermined solar elevation angle.

Abstract: Glass-based article including a first surface and a second surface opposing the first surface defining a thickness (t), and a stress profile are disclosed having a thickness (t) of about 3 millimeters or less, and wherein all points of the stress profile between a thickness range from about 0·t up to 0.3·t and from greater than 0.7·t, comprise a tangent with a slope that is less than about ?0.1 MPa/micrometers or greater than about 0.1 MPa/micrometers. Also disclosed are glass-based articles having a thickness (t) in a range of 0.1 mm and 2 mm; and wherein at least one point of the stress profile in a first thickness range from about 0·t up to 0.020·t and greater than 0.98·t comprises a tangent with a slope of from about ?200 MPa/micrometer to about ?25 MPa/micrometer or about 25 MPa/micrometer to about 200 MPa/micrometer, and wherein all points of the stress profile in a second thickness range from about 0.035·t and less than 0.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.