Abstract: There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.

Abstract: Aspects of the present disclosure provide techniques for providing a graphical user interface. Embodiments include displaying text input fields corresponding to days of a week. Embodiments include receiving a selection of a first text input field of the text input fields corresponding to a day of the week. Embodiments include displaying, based on the selection of the first text input field, an additional text input field for entering text related to the day of the week. Embodiments include receiving a selection of a second text input field of the text input fields corresponding to another day of the week. Embodiments include displaying, based on the selection of the second text input field, an additional text input field for entering text related to the other day of the week in place of the additional text input field related to the day of the week.

Abstract: Devices and processes provide for geophysical oil, gas, or mineral prospecting and subsurface fluid monitoring, using a controlled source electromagnetic system that transmits a designed probe wave to create images of sub-surface structures and fluids either statically or while in motion.

Abstract: Aspects of the present disclosure provide techniques for providing a graphical user interface. Embodiments include displaying text input fields corresponding to days of a week. Embodiments include receiving a selection of a first text input field of the text input fields corresponding to a day of the week. Embodiments include displaying, based on the selection of the first text input field, an additional text input field for entering text related to the day of the week. Embodiments include receiving a selection of a second text input field of the text input fields corresponding to another day of the week. Embodiments include displaying, based on the selection of the second text input field, an additional text input field for entering text related to the other day of the week in place of the additional text input field related to the day of the week.

Abstract: There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.

Abstract: Devices and processes provide for geophysical oil, gas, or mineral prospecting and subsurface fluid monitoring, using a controlled source electromagnetic system that transmits a designed probe wave to create images of sub-surface structures and fluids either statically or while in motion.

Abstract: A container includes a receptacle (6) for holding a substance, drug or liquid, and having an opening (7) to the receptacle 6 through which the substance can be dispensed and having a circular and domed spreading surface (15) adjacent the opening for spreading and the accurate delivery of a thin layer of liquid over an area of skin. The container also includes a closure (3) including a cap (4) having a seal or plug (16) for sealing the receptacle (6), and a collar (5) with a cam follower surface (8) rotatable relative to the cap about an axis, whereby rotation of the collar (5) relative to the cap (4) moves the seal in an axial direction away from a seal position.

Abstract: A method of treatment or prophylaxis of amyloidosis disorders in a patient the method comprising topically applying to an area of skin of the patient a composition comprising: one or more zinc chelators; and one or more dermal penetration enhancers.

Abstract: The present invention presents a method, system and computer-implementable medium for remapping child references when parent reference updates are processed.

Abstract: A diagnostic system is disclosed. In one embodiment, the system includes i) an input interface for use by a person to submit user profile data, physical data and psychological data to the system, the physical data representing heart rate, blood pressure, and other biophysical parameters of the person, the psychological data representing quality of life and needs satisfaction and other psychological parameters of the person, ii) an analyzer for processing the physical data and psychological data to generate risk profile data based on criteria data for conditions and iii) an output interface for providing risk profile displays using the risk profile data to present for the person risk levels associated with the conditions.

Abstract: A method for consolidating a database in a Seibel CRM environment is presented. Bypassing the Business Object Layer (BOL) of the Seibel CRM environment, primary keys in a consolidated table are realigned such that a consolidated child table, created from two distinct databases, is able to point to reference items in a single parent table.

Abstract: The present invention provides a transdermal drug delivery system which comprises: a therapeutically effective amount of a non-steroidal anti-inflammatory drug; at least one dermal penetration enhancer, which is a safe skin-tolerant ester sunscreen ester; and at least one volatile liquid. The invention also provides a method for administering at least one systemic or locally acting non-steroidal anti-inflammatory drug to an animal which comprises applying an effective amount of the non-steroidal anti-inflammatory drug in the form of the drug delivery system of the present invention.

Abstract: The invention relates to a method for treatment or prophylaxis of a disease or condition in an animal comprising administering to a mucosal membrane of said animal in need of such treatment a therapeutically effective amount of a drug delivery system comprising at least one physiologically active agent or prodrug thereof and at least one penetration enhancer selected from safe ester sunscreens.

Abstract: A topical cosmetic composition including: at least one water-soluble cosmetic agent; at least one oil-soluble cosmetic agent; and a dermal penetration enhancer, wherein topical application of the composition results in the delivery of the water-soluble and oil-soluble cosmetic agents into the stratum corneum as well as delivery of the oil-soluble cosmetic agent into the epidermis and dermis.

Abstract: The present invention provides a pharmaceutical composition for transdermal delivery comprising: one or more physiologically active agents; one or more dermal penetration enhancers; a pharmaceutically acceptable carrier comprising a volatile solvent; and a hydrofluorocarbon propellent; wherein the carrier and penetration enhancers combine to provide a single-phase solution of the one or more physiologically active agents.

Abstract: The present invention provides a pharmaceutical composition for transdermal delivery comprising; one or more physiologically active agents; and a volatile pharmaceutically acceptable solvent; and wherein the physiological active agent forms a metastable deposit upon evaporation of the volatile solvent.

Abstract: A pharmaceutical composition for transdermal delivery comprising one or more physiologically active agents; one or more dermal penetration enhancers; and a volatile pharmaceutically acceptable carrier comprising a volatile solvent; and wherein the physiologically active agent and dermal penetration enhancer form an amorphous deposit upon evaporation of the volatile carrier, said amorphous deposit forming a reservoir within the stratum corneum; and (A) wherein the composition has a release rate profile of physiologically active agent so as to provide a ratio of the maximum concentration (Cmax) to the average concentration (Cavg) for the physiologically active agent over the dosage interval within the range of 1 to 10.