Abstract: A transcranial focused ultrasound (tFUS) system treats and reduces brain damage in stroke, heart attack, and cardiac arrest patients. More generally, this tFUS system can also be used to treat neurotrauma where a physical issue can cause unhealthy neural activity changes (dysregulation), in particular over-excitation or excessive depolarization, that then leads to large-scale neural death or connectivity changes, potentially through a positive feedback loop in dysregulation. Thus, applications could include neurotrauma, including traumatic brain injury and concussions. The system allows for monitoring the efficacy of the treatment and adjusting the sonication parameters. The system integrates other diagnostic and treatment systems, such as MRI, fNIRS, hypothermic chamber, etc. A method utilizing a tFUS system treats and reduces brain damage in those suffering from stroke, heart attack, cardiac arrest, or neurotrauma.

Abstract: A transcranial Focused Ultrasound (tFUS) system uses a neural network to correct skull aberrations and maximizes the transmission of ultrasound waves through the skull. A method using supervised learning generates aberration correction parameters to be used by the receiver and transmitter of the tFUS system. A method utilizing these aberration correction parameters operating on the tFUS system maximizes the coherence of ultrasound waves passing through the skull. The method maximizes the amount of power transmitted through the skull, given a fixed maximum pressure (for example, determined by regulatory requirements).

Abstract: A transcranial focused ultrasound (tFUS) system integrates ultrasound and electroencephalogram (EEG) systems by providing ultrasound posts and EEG posts. A holder unit holds one or more arrays of posts that enable vertical movement and prevent lateral movement. The one or more arrays of posts include: one or more ultrasound transmitting posts, and one or more electroencephalogram (EEG) posts.

Abstract: A transcranial focused ultrasound (tFUS) system integrates ultrasound and electroencephalogram (EEG) systems. A holder unit can include a housing or frame structure, one or more ultrasound transducers, and one or more EEG electrodes. The holder unit holds a particular EEG electrode in a predetermined position relative to an ultrasound pressure field of an ultrasound transducer to reduce noise in EEG data.

Abstract: Cranial acoustic coupling apparatuses and methods to improve coupling to the head for use in transcranial focused ultrasound systems (tFUS) are disclosed. The apparatuses are constructed using multiple components and layers to reduce the air gaps due to head curvature and smaller-scale features such as dimples, hair, and so on. An apparatus or system can include a holder unit and an attachment puck. The holder unit can include one or more ultrasound transducers. The attachment puck can include an attachment layer that interfaces with a head.

Abstract: A transcranial focused ultrasound (tFUS) system integrates ultrasound and electroencephalogram (EEG) systems along with neuro-navigational aids to improve ultrasound beam guidance. A holder unit can include a housing or frame structure and neuro-navigational aids. The holder unit can hold one or more ultrasound transducers and one or more electroencephalogram (EEG) enabling the EEG electrodes to be used for ultrasound beam guidance and coupling.

Abstract: A trans-cranial Focused Ultrasound System (tFUS) apparatus employs an ultrasonic stimulation beam that is guided by ultrasonic imaging or optical imaging to optimize a response of a subject during a procedure. The disclosed tFUS apparatus is operable without requiring either an MRI or a CT scan. The use of multiple transducers or transducer elements, including contralateral transducers, the use of ultrasonic and/or optical harmonics, the use of temporal windows, the use of a head atlas, motion tracking, LiDAR, and the use of aberration correction parameters may all be employed individually or in combination.

Abstract: Window hinge assemblies including a hinge pin support and methods of using the same are described herein. The hinge assemblies include a track assembly, a shoe slidably engaged in a track of the track assembly, a sash arm configured for attachment to a rotating sash, the sash arm being pivotally attached to the shoe, and a connecting arm. The track assembly includes a base extending along a track axis, a shoe track extending along the track axis, a hinge pin attached to the base of the track assembly, and a hinge pin support restraining an upper end of the hinge pin from movement relative to the base.

Abstract: Double-hung window actuators exhibiting one or more of several beneficial features are disclosed. They can include bidirectional linear drive mechanisms sized to fit at least partially inside channels defined at least in part by the jamb runs of a movable sash. These drive mechanisms can be built around a right mounting support of adequate stiffness to support the mechanism independent of external support. Sash pin interfaces can interact with sash pins on the window. Actuation load sensors can detect changes in loading of the actuators, and an edge sensor can be electrically connected to the drive mechanisms. The actuators can be housed in a housing that includes a window apron for mounting below the window.

Abstract: A mobile key includes an RFID tag associated with a memory. The memory holds a secure access code. An authorization status for a person or item associated with the mobile key is determined by interrogating the mobile key using an RFID interrogation field. Security information, such as a secure identifier or access code, physical measurement data, or biometric data may be provided by the mobile key. The key may also comprise a wireless communication device, such as a cellular telephone. Security information, such as an access code, may be provided to the key using the wireless communication device or other communications network.

Abstract: An electrical enclosure having an improved sealing and shielding component and a method of manufacturing such an enclosure is provided. In accordance with an embodiment of the invention, a wire mesh is positioned against the surface of the enclosure. While the wire mesh is being positioned against the enclosure surface, a foam is formed on the enclosure surface adjacent the wire mesh. The foam generally adheres to the enclosure surface and holds the wire mesh in place. In accordance with one aspect of the invention, the foam has a height equal to or greater than the height of the wire mesh. The improved sealing and shielding components can, for example, improve the sealing and shielding of the electrical enclosure as compared to conventional electrical enclosures. The present electrical enclosure may, for example, also reduce the cost of manufacturing electrical enclosures.