Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: The present disclosure provides a method and system by which a precise amount of a viscous fluid sealing compound can be dispensed at required locations through computer vision-based observation of the fluid deposited, its rate and amount of deposition and location; and that the dispensed fluid may be accurately shaped through robotic or other special purpose mechanism motion. The invention enables instant quality inspection of the dispensing process in terms of the locations, amounts and shapes of newly created seals.

Abstract: A coaxial sensor array system configured for prediction of leaks in a water distribution network based on data acquired from coaxial sensor array including: at least one hydrophone; a hydrophone mount configured to house the at least one hydrophone; a pressure transducer configured to measure pressure of a water column within which the plurality of hydrophones is submerged; a pressure transducer mount implemented as a lead-free brass disc configured for fitment of the pressure transducer; an electrical connector configured to connect communication cables to the pressure transducer; a sensor housing configured to house the at least one hydrophone and the pressure transducer; and an end cap configured to seal a back end of the coaxial sensor array system and further configured to allow communications to pass through into a watertight shielded flexible conduit.

Abstract: Systems and methods are provided that automatically determine whether a prospective surgical trajectory will collide with a patient's skull using a 3D representation of the patient's cranial region (including the patient's scalp, skull, and brain) adapted from imaging data of the patient's cranial region (e.g., MRI data or CT data). Taking a particular patient's varied skull thickness into account, examples can determine bone collision during a trajectory planning stage before or after a stereotactic frame is mounted to the patient. Accordingly, examples may preemptively alert a clinician to a potential bone collision before the prospective surgical trajectory is underway/has been executed, thereby reducing the risk of bone collision during the surgical procedure.

Abstract: A fan assembly including a base arranged to support the fan assembly on a surface, an air flow generator that is arranged to generate an air flow, and an air outlet that is arranged to emit at least a portion of the air flow from the fan assembly is provided. The air outlet is arranged to be oscillated relative to the base. The fan assembly further includes a controller that is arranged to control the oscillation of the air outlet relative to the base. The controller is arranged to vary an oscillation speed of the air outlet for each oscillation.

Abstract: Disclosed is a fan including a nozzle having an air outlet through which an airflow is expelled in an axial direction. The fan includes an axial perturbation device for applying a velocity perturbation at a first frequency to the airflow in the axial direction.

Abstract: A nozzle for a fan assembly includes an air inlet, a first air outlet and a second air outlet that are oriented in convergent directions, and a valve for controlling the first and second air outlets. The valve includes one or more valve members that are moveable to simultaneously adjust the size of the first air outlet and inversely adjust the size of the second air outlet. The nozzle further includes a third air outlet and a fourth air outlet, the third air outlet being opposite the fourth air outlet, the third and fourth air outlets being oriented in convergent directions.

Abstract: A fan assembly including a base arranged to support the fan assembly on a surface, an air flow generator that is arranged to generate an air flow, and an air outlet that is arranged to emit at least a portion of the air flow from the fan assembly is provided. The air outlet is arranged to be oscillated relative to the base. The fan assembly further includes a controller that is arranged to control the oscillation of the air outlet relative to the base. The controller is arranged to vary an oscillation speed of the air outlet for each oscillation.

Abstract: There is provided a nozzle for a fan assembly. The nozzle comprises an air inlet, a first air outlet and a second air outlet that are oriented in convergent directions, and a valve for controlling the first and second air outlets. The valve comprises one or more valve members that are moveable to simultaneously adjust the size of the first air outlet and inversely adjust the size of the second air outlet. The nozzle further comprises a third air outlet and a fourth air outlet, the third air outlet being opposite the fourth air outlet, the third and fourth air outlets being oriented in convergent directions, and the third air outlet and the fourth air outlet each being substantially perpendicular to each of the first and second air outlets.

Abstract: There is provided a nozzle for a fan assembly. The nozzle comprises an air inlet, a first air outlet for emitting an air flow and a second air outlet for emitting an air flow, the first and second air outlets together defining an aggregate air outlet of the nozzle, a single internal air passageway extending between the air inlet and the first and second air outlets, and a valve for controlling an air flow from the air inlet to the first and second air outlets. The valve comprises one or more valve members that are moveable to adjust the size of the first air outlet relative to the size of the second air outlet while keeping the size of the aggregate air outlet of the nozzle constant, and wherein the air outlets are oriented towards a convergent point.

Abstract: A tank container includes a frame having a front end opposite a rear end that defines a rear plane, a vessel extending between the front end and the rear end of the frame, and a discharge valve assembly. The discharge valve assembly comprises an internal bottom valve, an adaptor, and a discharge valve. The internal bottom valve is positioned within an interior volume of the vessel and the discharge valve is positioned entirely within the frame and offset at least one inch from the rear plane. The adaptor curves downwardly between the internal bottom valve and the discharge valve.

Abstract: A fan assembly including a base arranged to support the fan assembly on a surface, an air flow generator that is arranged to generate an air flow, and an air outlet that is arranged to emit at least a portion of the air flow from the fan assembly is provided. The air outlet is arranged to be oscillated relative to the base. The fan assembly further includes a controller that is arranged to control the oscillation of the air outlet relative to the base. The controller is arranged to vary an oscillation speed of the air outlet for each oscillation.

Abstract: This invention provides mass spectrometry (MS) compatible nanomaterials for the selective capture and enrichment of low abundance proteins as well as MS analysis of different proteoforms of proteins, particularly cardiac proteins and different proteoforms of cardiac troponin I (cTnI) arising from post-translational modifications and sequence variations. The surface of superparamagnetic nanoparticles is functionalized with probe molecules that specifically bind to the desired protein. In an embodiment, the nanoparticles are functionalized with probe molecules having high affinity and selectivity for cTnI within the human cardiac troponin complex. This allows for MS-analysis and characterization of cTnI proteoforms from human heart tissue lysates and human blood or serum samples, and provides an accurate assay for detection of cTnI with molecular details.

Abstract: There is provided a nozzle for a fan assembly. The nozzle comprises an air inlet, a first air outlet for emitting an air flow and a second air outlet for emitting an air flow, the first and second air outlets together defining an aggregate air outlet of the nozzle, a single internal air passageway extending between the air inlet and the first and second air outlets, and a valve for controlling an air flow from the air inlet to the first and second air outlets. The valve comprises one or more valve members that are moveable to adjust the size of the first air outlet relative to the size of the second air outlet while keeping the size of the aggregate air outlet of the nozzle constant, and wherein the air outlets are oriented towards a convergent point.

Abstract: There is provided a nozzle for a fan assembly. The nozzle comprises an air inlet, a first air outlet for emitting an air flow and a second air outlet for emitting an air flow, the first and second air outlets together defining an aggregate air outlet of the nozzle, a single internal air passageway extending between the air inlet and the first and second air outlets, and a valve for controlling an air flow from the air inlet to the first and second air outlets.

Abstract: Circuits and computer program products onboard and/or adapted to communicate with an scanner that electronically recognize predefined physical characteristics of the at least one tool to automatically segment image data provided by the scanner whereby the at least one tool constitutes a point of interface with the system. The circuits and computer program products are configured to provide a User Interface that defines workflow progression for an image guided surgical procedure and allows a user to select steps in the workflow, and generate multi-dimensional visualizations using the predefined data of the at least one tool and data from images of the patient in substantially real time during the surgical procedure.

Abstract: There is provided a nozzle for a fan assembly. The nozzle comprises an air inlet, a first air outlet and a second air outlet that are oriented in convergent directions, and a valve for controlling the first and second air outlets. The valve comprises one or more valve members that are moveable to simultaneously adjust the size of the first air outlet and inversely adjust the size of the second air outlet. The nozzle further comprises a third air outlet and a fourth air outlet, the third air outlet being opposite the fourth air outlet, the third and fourth air outlets being oriented in convergent directions, and the third air outlet and the fourth air outlet each being substantially perpendicular to each of the first and second air outlets.

Abstract: Surgical planning systems that automatically identify one or a plurality of different candidate trajectories to a defined intrabody treatment region. The systems can rank the identified candidate trajectories in an order of hierarchy based on defined parameters such as distance from a critical no-go location and whether a single or multiple different candidate trajectories are needed to provide coverage of the defined intrabody treatment region. The surgical planning systems are also configured to provide a User Interface that defines a workflow for an image-guided surgical procedure and allows a user to select one or more of the identified candidate trajectories steps in the workflow.

Abstract: There is provided a nozzle for a fan assembly. The nozzle comprises an air inlet, a first air outlet for emitting an air flow and a second air outlet for emitting an air flow, the first and second air outlets together defining an aggregate air outlet of the nozzle, a single internal air passageway extending between the air inlet and the first and second air outlets, and a valve for controlling an air flow from the air inlet to the first and second air outlets. The valve comprises one or more valve members that are moveable to adjust the size of the first air outlet relative to the size of the second air outlet while keeping the size of the aggregate air outlet of the nozzle constant, and wherein the air outlets are oriented towards a convergent point.

Abstract: Circuits and computer program products onboard and/or adapted to communicate with an scanner that electronically recognize predefined physical characteristics of the at least one tool to automatically segment image data provided by the scanner whereby the at least one tool constitutes a point of interface with the system. The circuits and computer program products are configured to provide a User Interface that defines workflow progression for an image guided surgical procedure and allows a user to select steps in the workflow, and generate multi-dimensional visualizations using the predefined data of the at least one tool and data from images of the patient in substantially real time during the surgical procedure.