Abstract: Process control parameters are predicted to fabricate an object using deposition. An input design geometry is provided for the object. A training data set includes past post-build physical inspection data for a plurality of objects that comprise at least one object that is different from the object to be physically fabricated; and training data generated through a repetitive process of randomly choosing values for each of multiple process control parameters and scoring adjustments to the multiple process control parameters as leading to either undesirable or desirable outcomes, the outcomes based respectively on the presence or absence of defects detected in a fabricated object arising from the process control parameter adjustments. A machine learning algorithm is trained using the provided training data set and a predicted optimal set of the multiple process control parameters is generated for initiating and performing the deposition process to fabricate the object.

Abstract: A dissolution testing apparatus includes a base structure, a vessel support structure, a cleaning manifold and a stirring mechanism. The vessel support structure is configured for mounting testing vessels and is rotatably mounted to the base structure. The vessel support structure is rotatable from an upright position at which respective open ends of the vessels face upwardly to an inverted position at which the open ends face downwardly. The cleaning manifold is mounted to base structure below the vessel support structure and is configured for directing a fluid into the vessels while the vessel support structure is at the inverted position. The stirring mechanism includes shafts and is movably mounted to the base structure. The stirring mechanism is movable from a lower position at which the shafts extend into the vessels to an upper position at which the shafts are outside the vessels. At the upper position the stirring mechanism provides clearance for the vessel support structure to rotate.

Abstract: An automated MicroSampling dissolution testing system that is constructed of a base; a plurality of vessels mounted on an invertible, temperature controlled bath manifold; a cleaning manifold; a stirring and sampling assembly for each vessel; an integrated image capture device, a plurality of hydrodynamic, nonresident sampling probes; a non-resident dispensing manifold; a novel fluid handling system; a MicroSampler; a sample transfer mechanism; and a sample and filter storage apparatus.