Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.

Abstract: A fifth wheel includes a top plate having a throat that is adapted to receive a kingpin of a trailer. The fifth wheel is equipped with a locking mechanism including a jaw slidably connected to the top plate and slidable between a closed position where the jaw blocks passage of a kingpin out of the throat of the fifth wheel and an open position where a kingpin may pass into and out of the throat of the fifth wheel. The jaw has an edge adapted to engage a kingpin positioned in the throat of the fifth wheel when the jaw is in the closed position. A bias device urges the jaw towards the closed position. The fifth wheel further includes a mechanism for moving the jaw between the open and closed positions. Further, the top plate of the fifth wheel is configured to allow service and/or replacement of the jaw from the top of the fifth wheel while it is assembled to a vehicle.

Abstract: The system includes a memory and a processing system. The memory stores a GUI template, the GUI template including information identifying data fields and indicating locations for the data fields on a screen. The processing system is able to display the data fields identified by the GUI template on the screen at the locations indicated by the GUI template, to retrieve a record from a database, and to populate the data fields on the screen with data from the record. The processing system is further able to move a data field to a new location on the screen based on input from a user while the data field is populated with data from the record, and to update a location for the data field indicated by the GUI template to specify the new location.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted first gear wheel having ratchet teeth and a display coupled to the first gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the first gear wheel. The dose counter further includes an actuator mechanism having a first ratchet drive pawl for engaging the ratchet teeth of the first gear wheel in response to the dispensation of a medicament dose, and a second ratchet drive pawl for engaging the ratchet teeth of a gear wheel coupled to the display. In use, a first ratchet tooth of the first gear wheel is rotatably driven by the first pawl and then a second ratchet tooth of the gear wheel coupled to the display is rotatably driven by the second pawl.

Abstract: A dose counter for counting does of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes a rotatably mounted gear wheel having a circular arrangement of ratchet teeth defining a root circle and a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel. The dose counter further includes an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes an actuator shaft mounted for linear movement in response to the dispensing of a dose of medicament. In use, the travel of the driver along the root circle of the gear wheel exceeds the corresponding linear movement of the actuator shaft.

Abstract: A dose counter for counting doses of medicament dispensed by or remaining in a metered-dose inhaler. The dose counter includes: a rotatably mounted gear wheel having a circular arrangement of ratchet teeth; a display coupled to the gear wheel, the display having a visible array of dose counting indicia indexable in response to rotary motion of the gear wheel; and an actuator mechanism having a driver for rotatably driving the gear wheel in response to the dispensation of a medicament dose, the driver being arranged to engage the ratchet teeth of the gear wheel. The actuator mechanism includes a pivotally mounted lever having an input portion. The lever is arranged to amplify a linear stroke at the input portion such that a linear stroke of the driver exceeds the linear input stroke. By amplifying the stroke, the risk of undercounting due to insufficient stroke length may be reduced.

Abstract: The present invention provides an albumin-binding compound essentially of the following elements: a spacer group, a water-soluble bridging group, a fatty acid chain and an acidic group characterised in that the acidic group is attached to the distal end of the fatty acid chain. The invention also provides an albumin-binding compound to which one or more biologically active moieties are attached.

Abstract: A universal mounting (1) for a vehicle rear view mirror (2) adapted to fit on a mirror arm (4) of any cross-section comprising a mirror arm engaging surface (3, 8, 18) and clamping means (5), in which the clamping means are adapted to extend around or through a mirror arm (4) with which the mounting is to be used, and to urge the mirror arm engaging surface (3, 8, 18) against said mirror arm (4), and in which the mirror arm engaging surface is adapted to engage mirror arms of any cross section.

Abstract: Branched molecular scaffolds are provided which are capable of linking two polymer residues (derived, for example, from polyethylene glycol) to two, three or four residues derived from biologically active molecules (e.g. from whole antibodies or from functionally active fragments or derivatives thereof), the latter being attached to the scaffold by means of hydrolytically stable linkages.

Abstract: Systems and techniques for entry and presentation of project planning information, showing activities in their geographic context. Information relating to activities and groupings of activities is entered, updated and presented. Information associated with one or more groupings of activities is associated with a graphical icon, with the appearance of the icon changing in response to changes in the associated information. The icon is placed in a graphical display, with the graphical display showing geographic information, such as a map, and the icon being placed in a map location showing the location of the activities associated with the icon. The graphical display maintains links to the information associated with the icon so that updating the information changes the appearance of the icon, calling attention to changes in their geographic context.

Abstract: Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The lipids are of particular use for the delivery of bioactive substances such as nucleic acids to cells in vitro and especially in vivo.

Abstract: A system and method of controlling distribution of electronic information to a device through a non-bidirectional protocol is disclosed. At a user device, a segment of encrypted electronic information is retrieved. Identification data is sent from the user device using the non-bidirectional communications protocol, where the identification information includes at least one of information associated with a user, information associated with the user device, or information associated with the segment of encrypted electronic information. A copy of an encryption key for the segment is retrieved. A voucher is forwarded to the user device using the non-bidirectional communications protocol, the voucher including at least the encryption key associated with the segment. At the user device, the segment is decrypted using the encryption key for the segment.

Abstract: In an embodiment, a weld head for use in bonding antennas to IC modules in a sheet of smart card modules includes an integrated test unit, e.g., a reader/writer (R/W) unit. The test unit tests the bonds between the antenna and the IC module in a selected card module by attempting to communicate with the IC module with low-wattage RF waves via the card module's antenna.

Abstract: An apparatus for collecting and discharging live marine animals, the apparatus having a collection chamber for holding the marine animals, an inlet conduit having one end extendible into a body of water containing the marine animals, and another end in fluid communication with the chamber, the conduit being sized to allow the marine animals to pass therethrough, a pump to suck water out of the chamber which also causes water to flow through the conduit and into the chamber thereby carrying the marine animals through the conduit and into the chamber, a screen to prevent the marine animals from being sucked into the pump, a discharge outlet through which the marine animals can pass out of the apparatus, and a mechanism the marine animals through the discharge outlet.

Abstract: A stopper mechanism includes: an arm part which is a part of a cover; an arc-like projection part at the end of the arm part; and a sliding member slidably provided in the cover. When the sliding member flanks the projection part, the arm part is prevented thereby from being bent and a stopper mechanism is locked. When the sliding member is allowed to slide and to be removed from behind the projection part, the arm part is allowed to be bent, and the stopper mechanism is unlocked.