Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.

Abstract: The invention concerns a co-processed additive for a solid-dose pharmaceutical composition, the additive comprising from about 50% to 99.5% by weight of at least one pharmaceutical compression aid and from about 0.5% to 50% by weight of at least one pharmaceutical lubricant, the melting point of said compression aid(s) being higher than the melting point of said lubricant(s). The co-processed additive may be in the form of a physically bound composite whereby the lubricant is associated with the surface of the compression aid particles.

Abstract: A sexual aid device comprising: a generally cylindrically shaped shaft; a set of shaft threads on the first end of the shaft; a first head attached to the second end of the shaft; a plurality of inserts configured to slide along the shaft and configured to not be able to slide over the first head; and a second head with a set of internal threads configured to mate with the shaft threads, wherein when the second head is attached to the second end of the shaft, any inserts located on the shaft are held in place on the shaft by the first and second heads.

Abstract: The invention concerns a co-processed additive for a solid-dose pharmaceutical composition, the additive comprising from about 50% to 99.5% by weight of at least one pharmaceutical compression aid and from about 0.5% to 50% by weight of at least one pharmaceutical lubricant, the melting point of said compression aid(s) being higher than the melting point of said lubricant(s). The co-processed additive may be in the form of a physically bound composite whereby the lubricant is associated with the surface of the compression aid particles.

Abstract: The present invention consists of a conversion quick pitch system and method for converting a spring-actuated pitching machine of the Iron Mike type to a video pitching machine, i.e., a pitching machine that includes a video projection screen on which the video image of an actual pitcher is displayed in synchronization with the release of a ball from the pitching machine. The quick pitch system and method includes a projection screen; a projector; a clutch motor unit and a first and a second cam switch; a relay unit; and a control unit. The projection screen, which is adapted to be positioned between the pitching machine and a batter, includes an aperture through which a ball may be delivered to the batter by the conventional spring-actuated pitching machine. The video projector must be able to project the video image of an actual pitcher onto the projection screen.

Abstract: The present invention comprises a unique mounting frame for use in conjunction with a conversion kit for a conventional, combination baseball/softball pitching machine of the wheel type. Both machines are separately mounted on individual base plates that are pivotably mounted to the front of the frame. The plates are interconnected so as to move in an integral manner pivoting relative to the front of the frame. Movement is controlled by a linear actuator which permits them to be raised and lowered as a single unit by a single raise and lower mechanism.

Abstract: The present invention consists of a conversion kit for converting a pitching machine of the type having at least one wheel into a video pitching machine. The kit includes: a projection screen; projector; ball injector; and control system. The projection screen, which is adapted to be positioned between the pitching machine and a batter, includes an aperture through which a ball may be delivered to the batter by the pitching machine. The video projector must be able to project the video image of an actual pitcher onto the projection screen. The injector is adapted to hold a ball in a queued position immediately behind the pitching machine and inject the ball into the pitching machine to be propelled toward the batter in synchronization with the video image. The injector includes an electric solenoid for injecting the ball into the pitching machine.

Abstract: The present invention consists of a conversion kit for converting a spring-actuated pitching machine of the Iron Mike type to a video pitching machine, i.e., a pitching machine that includes a video projection screen on which the video image of an actual pitcher is displayed in synchronization with the release of a ball from the pitching machine. The kit includes a projection screen; a projector; a clutch motor unit; a relay unit; and a control unit. The projection screen, which is adapted to be positioned between the pitching machine and a batter, includes an aperture through which a ball may be delivered to the batter by the conventional spring-actuated pitching machine. The video projector must be able to project the video image of an actual pitcher onto the projection screen. The clutch motor is adapted to hold a ball in a queued position within the spring-actuated pitching machine and, upon release, propel the ball toward the batter in synchronization with the video image.

Abstract: The present invention consists of a conversion kit for converting a pitching machine of the type having at least one wheel into a video pitching machine. The kit includes: a projection screen; projector; injector means; and control means. The projection screen, which is adapted to be positioned between the pitching machine and a batter, includes an aperture through which a ball may delivered to the batter by the pitching machine. The video projector must be able to project the video image of an actual pitcher onto the projection screen. The injector means are adapted to hold a ball in a queued position immediately behind the pitching machine and inject the ball into the pitching machine to be propelled toward the batter in synchronization with the video image. The injector means includes an electric solenoid for injecting the ball into the pitching machine.

Abstract: The present invention comprises a unique mounting frame for use in conjunction with a conversion kit for a conventional, combination baseball/softball pitching machine of the wheel type. Both machines are separately mounted on individual base plates that are pivotably mounted to the front of the frame. The plates are interconnected so as to move in an integral manner pivoting relative to the front of the frame. Movement is controlled by a linear actuator which permits them to be raised and lowered as a single unit by a single raise and lower mechanism.