Abstract: Fatostatin, a recently described inhibitor of SREBP activation, significantly reduces the level of mutant p53 binding to the HMG-CoA reductase gene promoter. Further, fatostatin treatment had a dramatic effect on normalizing the abnormal 3D morphology of 3 strains of breast cancer cells: MDA-468 cells, MDA-231 cells, and SKBR3 cells. The results show a functional interaction with SREBPs as being critical for mutant p53-mediated upregulation of the mevalonate pathway genes. At a clinical level, inhibition of the mevalonate pathway, either alone or in combination with other therapies, offers a novel, safe and much needed therapeutic option for tumors bearing mutant p53.

Abstract: Embodiments are disclosed that relate to displaying images on multi-display devices with low latency. For example, one disclosed embodiment provides, on a display device comprising a first display and a second display, a method comprising receiving, processing a first image, and displaying the first image via the first display and not displaying the first image via the second display. The method further comprises receiving a second image, processing the second image while displaying the first image, and displaying the second image via the second display and not displaying the second image via the first display.

Abstract: Cache management strategies are described for retrieving information from a storage medium, such as an optical disc, using a cache memory including multiple cache segments. A first group of cache segments can be devoted to handling the streaming transfer of a first type of information, and a second group of cache segments can be devoted to handling the bulk transfer of a second type of information. A host system can provide hinting information that identifies which group of cache segments that a particular read request targets. A circular wrap-around fill strategy can be used to iteratively supply new information to the cache segments upon cache hits by performing pre-fetching. Various eviction algorithms can be used to select a cache segment for flushing and refilling upon a cache miss, such as a least recently used (LRU) algorithm or a least frequently used (LFU) algorithm.

Abstract: Interactive simulation including force feedback. The system includes a computer game display unit programmed with simulation rules. A control unit is connected to the computer and provides information and control signals to the computer to interact with the stored simulation rules and to receive information and control signals from the computer. A movable structure for movement in at least two degrees-of-freedom by an operator is interconnected to the control unit by means of actuators. A programmable unit processes signals and information from the computer to generate signals to drive the actuators so as to apply forces in the at least two degrees-of-freedom to the movable structure and thereby to the operator. The applied forces are based on internal programming within the programmable unit, events occurring in the simulation and movements of and forces applied to the movable structure by the operator.

Abstract: Interactive simulation including force feedback. The system includes a computer game display unit programmed with simulation rules. A control unit is connected to the computer and provides information and control signals to the computer to interact with the stored simulation rules and to receive information and control signals from the computer. A movable structure for movement in at least two degrees-of-freedom by an operator is interconnected to the control unit by actuators. A programmable unit processes signals and information from the computer to generate signals to drive the actuators so as to apply forces in the at least two degrees-of-freedom to the movable structure and thereby to the operator. The applied forces are based on internal programming within the programmable unit, events occurring in the simulation and movements of and forces applied to the movable structure by the operator.

Abstract: Interactive simulation including force feedback. The system includes a computer game display unit programmed with simulation rules. A control unit is connected to the computer and provides information and control signals to the computer to interact with the stored simulation rules and to receive information and control signals from the computer. A movable structure for movement in at least two degrees-of-freedom by an operator is interconnected to the control unit by means of actuators. A programmable unit processes signals and information from the computer to generate signals to drive the actuators so as to apply forces in the at least two degrees-of-freedom to the movable structure and thereby to the operator. The applied forces are based on internal programming within the programmable unit, events occurring in the simulation and movements of and forces applied to the movable structure by the operator.

Abstract: Interactive simulation including force feedback. The system includes a computer game display unit programmed with simulation rules. A control unit is connected to the computer and provides information and control signals to the computer to interact with the stored simulation rules and to receive information and control signals from the computer. A movable structure for movement in at least two degrees-of-freedom by an operator is interconnected to the control unit by means of actuators. A programmable unit processes signals and information from the computer to generate signals to drive the actuators so as to apply forces in the at least two degrees-of-freedom to the movable structure and thereby to the operator. The applied forces are based on internal programming within the programmable unit, events occurring in the simulation and movements of and forces applied to the movable structure by the operator.

Abstract: A processor in a haptic joystick renders force effects that are applied to control handle gripped by a user. A plurality of force effects specified by a host computer to the processor are stored in a random access memory (RAM) that is coupled to the processor. Further, a plurality of force effects are stored in a read only memory (ROM) that is coupled to the processor. The processor employs a scheduler to render the force effects in a specified order, for specified time intervals. The scheduler controls how the force effects are rendered, i.e., sequentially, concatenated, and/or superimposed. A play list employed by the scheduler indicates for each increment of a servo clock when each force effect should be rendered by the processor. The scheduler has a round robin queue that can implement at least five types of effects, including: behavioral, synthesized, wave table, variable parameter, and process list.

Abstract: An input device for an interactive computer simulation or game is disclosed which includes a structure having at least two degrees-of-freedom which is moveable by a digit of a user to transmit input signal to a computer. At least one actuator connected to the moveable structure receives inputs from a computer and applies forces in the at least two degrees-of-freedom to the movable structure and thereby to the digit of the user. The actuator may include an electric motor and any of a variety of force transmission schemes including direct, cable, gear or belt drives. The applied forces are typically based on internal programming within the computer, events occurring in the simulation and movements of and forces applied to the movable structure by the operator.