Abstract: The present disclosure is directed to certain inhibitors of RLK and ITK of formula (I), pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by inhibition of RLK and ITK.

Abstract: Systems and techniques for predictive data analytics are described. In a method for selecting a predictive model for a prediction problem, the suitabilities of predictive modeling procedures for the prediction problem may be determined based on characteristics of the prediction problem and/or on attributes of the respective modeling procedures. A subset of the predictive modeling procedures may be selected based on the determined suitabilities of the selected modeling procedures for the prediction problem. A resource allocation schedule allocating computational resources for execution of the selected modeling procedures may be generated, based on the determined suitabilities of the selected modeling procedures for the prediction problem. Results of the execution of the selected modeling procedures in accordance with the resource allocation schedule may be obtained. A predictive model for the prediction problem may be selected based on those results.

Abstract: Systems and techniques for predictive data analytics are described. In a method for selecting a predictive model for a prediction problem, the suitabilities of predictive modeling procedures for the prediction problem may be determined based on characteristics of the prediction problem and/or on attributes of the respective modeling procedures. A subset of the predictive modeling procedures may be selected based on the determined suitabilities of the selected modeling procedures for the prediction problem. A resource allocation schedule allocating computational resources for execution of the selected modeling procedures may be generated, based on the determined suitabilities of the selected modeling procedures for the prediction problem. Results of the execution of the selected modeling procedures in accordance with the resource allocation schedule may be obtained. A predictive model for the prediction problem may be selected based on those results.

Abstract: An automated fence for being installed on a router table and including a plate for being fixed to a top surface of the table and a carriage movable relative to the plate, the carriage including spaced brackets, a fence, spaced rods interconnecting the brackets, the rods being slidable within bearing sleeves attached to the plate, a threaded rod attached to a motor for driving rotation of the threaded rod and the threaded rod being received within an internally threaded opening of a bracket fixed to the plate, a housing and a controller for actuating the motor.

Abstract: Systems and techniques for predictive data analytics are described. In a method for selecting a predictive model for a prediction problem, the suitabilities of predictive modeling procedures for the prediction problem may be determined based on characteristics of the prediction problem and/or on attributes of the respective modeling procedures. A subset of the predictive modeling procedures may be selected based on the determined suitabilities of the selected modeling procedures for the prediction problem. A resource allocation schedule allocating computational resources for execution of the selected modeling procedures may be generated, based on the determined suitabilities of the selected modeling procedures for the prediction problem. Results of the execution of the selected modeling procedures in accordance with the resource allocation schedule may be obtained. A predictive model for the prediction problem may be selected based on those results.

Abstract: Systems and techniques for predictive data analytics are described. In a method for selecting a predictive model for a prediction problem, the suitabilities of predictive modeling procedures for the prediction problem may be determined based on characteristics of the prediction problem and/or on attributes of the respective modeling procedures. A subset of the predictive modeling procedures may be selected based on the determined suitabilities of the selected modeling procedures for the prediction problem. A resource allocation schedule allocating computational resources for execution of the selected modeling procedures may be generated, based on the determined suitabilities of the selected modeling procedures for the prediction problem. Results of the execution of the selected modeling procedures in accordance with the resource allocation schedule may be obtained. A predictive model for the prediction problem may be selected based on those results.

Abstract: The present disclosure is directed to certain inhibitors of kinases such as ITK, BLK, BMX, BTK, JAK3, TEC, TXK, HER2 (ERBB2), or HER4 (ERBB4), in particular ITK, pharmaceutical compositions comprising such compounds, and method of treating diseases mediated by such kinases.

Abstract: An automated fence for being installed on a router table and including a plate for being fixed to a top surface of the table and a carriage movable relative to the plate, the carriage including spaced brackets, a fence, spaced rods interconnecting the brackets, the rods being slidable within bearing sleeves attached to the plate, a threaded rod attached to a motor for driving rotation of the threaded rod and the threaded rod being received within an internally threaded opening of a bracket fixed to the plate, a housing and a controller for actuating the motor.

Abstract: A method for virtually calibrating a CNC machine including the steps of selecting a true axis of movement of a toolhead of the CNC machine, instructing the toolhead to travel along the true axis of movement, selecting multiple points along an actual axis traveled by the toolhead, comparing the distance of the multiple points along the actual axis from the true axis to determine offset amounts from the true axis corresponding to a lack of straightness, and modifying g-code instructions to compensate for the offset amounts before uploading the g-codes to a CNC controller.

Abstract: The present disclosure is a method for controlling the hysteresis window and improving the color switching properties of reversible thermochromic dye systems. The method adds preferred co-solvents to existing reversible thermochromic dye systems in order to decrease the temperature range between the full color point and the clearing point. The co-solvents also add resistance to ultraviolet radiation.

Abstract: A flat screen television stand comprising a non-freestanding base pole adapted to be secured temporarily in upright fashion to a furniture support, and an inner pole telescopically and rotatably mounted in the base pole with its lower end resting on a transverse height adjustment pin in the base pole. The upper end of the inner pole is adapted to mount a flat screen television essentially tangentially to the pole. The flat screen television can be adjusted rotationally with hand pressure, without tools, but resists unintentional movement to maintain its adjusted position.

Abstract: A seam for use in a seat of a vehicle having a side airbag that deploys through a cover of the vehicle seat. The seam including a first material and a second material joined to the first material. A monofilament member used to join the first material to the second material. The monofilament member will allow for quicker and easier tearing of the seam thus allowing for more complete and quicker deployment of the airbag through the vehicle seat cover to protect the occupant from contact with interior surfaces of a vehicle.

Abstract: A continuous side airbag seam for use in a seat of a motor vehicle is disclosed. The seam includes a first material and a second material or a combination of materials joined to one another. The seam further may include any known thread member used to join the first material to the second material. The seam will extend from a portion near the top of the side panel of the seat cover to a portion near the back of the side panel of the seat cover. The seam will be continuous from the top portion to the back portion of the side panel cover of the seat. The continuous seam will have a predetermined shaped curve therein. The predetermined shaped curve will allow for quicker deployment of both the thorax section and pelvis section of an advanced two part side airbag to deploy both downward and forward in a controlled manner.

Abstract: A balloon for a catheter and a method of making the balloon, having a layer of a porous polymeric material with a modified outer surface and a lubricious coating bonded to the modified outer surface. In one embodiment, the modified outer surface is formed by a polymer impregnated in the porous polymeric material, and the subsequently applied lubricious coating bonds to the impregnating polymer. In another embodiment, the modified outer surface is formed by a functionality deposited on the porous polymeric material which bonds to the subsequently applied lubricious coating. The modified outer surface provides an improved strong bond between the lubricious coating and the balloon, for improved catheter performance.

Abstract: Compounds of the formula I: or pharmaceutically acceptable salts thereof wherein m, n, X, Ar, R1, R2, R3, R4 and R5 are as defined herein. Also provided are methods for preparing, compositions comprising, and methods for using compounds of formula I.

Abstract: A continuous side airbag seam for use in a seat of a motor vehicle is disclosed. The seam includes a first material and a second material or a combination of materials joined to one another. The seam further may include any known thread member used to join the first material to the second material. The seam will extend from a portion near the top of the side panel of the seat cover to a portion near the back of the side panel of the seat cover. The seam will be continuous from the top portion to the back portion of the side panel cover of the seat. The continuous seam will have a predetermined shaped curve therein. The predetermined shaped curve will allow for quicker deployment of both the thorax section and pelvis section of an advanced two part side airbag to deploy both downward and forward in a controlled manner.

Abstract: A golf ball is provided. The golf ball includes a hollow metal core made from a work-hardened metal alloy. The golf also includes a mantle layer enveloping the metal core. The mantle layer may be made from a mixture of long-ball resin and soft-ball resin. The golf ball further includes a cover positioned about the mantle layer to protect the mantle layer. A method of manufacturing the golf ball is also provided.

Abstract: A method for the manufacture of hollow metal spheres is provided. The method includes stamping appropriately-shaped hemispherical components and subsequently laser welding of the hemispheres. Metal spheres made by the method of the invention are substantially uniformly symmetrical in their mass distribution, and can provide superior performance in applications, such as golf ball cores and light-weight ball bearings.

Abstract: A computer readable medium for validating data is disclosed. The computer readable medium provides a computer readable medium with instructions executable by a computer to cause the computer to perform the following functions: receive a subjective representation of an address; re-format the subjective representation of the address according to a set of standardization rules; locate one or more candidate representations of the address from source data by recognizing that a preferred token is present among any of the one or more candidate representations of the address; select a preferred representation of the address from among the one or more candidate representations of the address based on the presence of the preferred token; and communicate the preferred representation of the address to an interface.

Abstract: A seam for use in a seat of a vehicle having a side airbag that deploys through a cover of the vehicle seat. The seam including a first material and a second material joined to the first material. A monofilament member used to join the first material to the second material. The monofilament member will allow for quicker and easier tearing of the seam thus allowing for more complete and quicker deployment of the airbag through the vehicle seat cover to protect the occupant from contact with interior surfaces of a vehicle.