Patents by Inventor Timothy P. Fleming

Timothy P. Fleming has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mode seeding cathode for a relativistic magnetron
    Patent number: 7245082
    Abstract: A high-power relativistic magnetron wherein the cathode geometry is shaped to form a DC electric field that has a non-negligible azimuthal component causing preferential selection of the pi mode at startup (suppression of mode competition), a significant increase in radiated power output and time integrated efficiency when compared to standard relativistic magnetron cathode designs.
    Type: Grant
    Filed: June 6, 2005
    Date of Patent: July 17, 2007
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventor: Timothy P. Fleming
  • Mammaglobin, a secreted mammary-specific breast cancer protein
    Patent number: 6677428
    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.
    Type: Grant
    Filed: May 30, 2000
    Date of Patent: January 13, 2004
    Assignee: Washington University
    Inventors: Mark A. Watson, Timothy P. Fleming
  • Mammaglobin, a secreted mammary-specific breast cancer protein
    Patent number: 6566072
    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.
    Type: Grant
    Filed: September 29, 1998
    Date of Patent: May 20, 2003
    Assignee: Washington University
    Inventors: Mark A. Watson, Timothy P. Fleming
  • Method for detecting the presence of breast cancer by detecting an increase in mammaglobin mRNA expression
    Patent number: 6004756
    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: December 21, 1999
    Assignee: Washington University
    Inventors: Mark A. Watson, Timothy P. Fleming
  • Mammaglobin, a mammary-specific breast cancer protein
    Patent number: 5968754
    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.
    Type: Grant
    Filed: May 20, 1998
    Date of Patent: October 19, 1999
    Assignee: Washington University
    Inventors: Mark A. Watson, Timothy P. Fleming
  • Mammaglobin antigens
    Patent number: 5922836
    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific secreted protein, mammaglobin, are disclosed. Also disclosed are methods for detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin. Immunotherapy-based methods for treating a breast cancer patient with a mammaglobin-expressing tumor are also disclosed. The methods involve using mammaglobin antigens to induce a humoral and/or cell-mediated immune response against the tumor.
    Type: Grant
    Filed: September 18, 1997
    Date of Patent: July 13, 1999
    Assignee: Washington University
    Inventors: Mark A. Watson, Timothy P. Fleming
  • Mammaglobin, a mammary-specific breast cancer protein
    Patent number: 5855889
    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.
    Type: Grant
    Filed: September 30, 1996
    Date of Patent: January 5, 1999
    Assignee: Washington University
    Inventors: Mark A. Watson, Timothy P. Fleming
  • Polynucleotides encoding mammaglobin, a mammary-specific breast cancer protein
    Patent number: 5668267
    Abstract: A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: September 16, 1997
    Assignee: Washington University
    Inventors: Mark A. Watson, Timothy P. Fleming
  • Immortalized epithelial cell lines
    Patent number: 5643782
    Abstract: An immortalized epithelial lens cell line obtained from human lens epithelial cells infected with hybride adenovirus/SV40 (Ad12-SV40), and methods for making and using the cell line are disclosed.
    Type: Grant
    Filed: August 23, 1993
    Date of Patent: July 1, 1997
    Assignee: Washington University in St. Louis
    Inventors: Usha P. Andley, Timothy P. Fleming