Patents by Inventor Timothy P. L. Roberts

Timothy P. L. Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Magnetoencephalography biomarkers of GABA-B agonist drug activity in autism spectrum disorders
    Patent number: 10342480
    Abstract: Methods for screening for therapies against autism spectrum disorders and methods for determining whether a subject would be responsive to a therapy against an autism spectrum disorder are disclosed.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: July 9, 2019
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Timothy P. L. Roberts, James Christopher Edgar
  • MAGNETOENCEPHALOGRAPHY BIOMARKERS OF GABA-B AGONIST DRUG ACTIVITY IN AUTISM SPECTRUM DISORDERS
    Publication number: 20160022207
    Abstract: Compositions and methods for diagnosing neurological disorders such as autism spectrum disorders are disclosed.
    Type: Application
    Filed: March 17, 2014
    Publication date: January 28, 2016
    Inventors: Timothy P.L. Roberts, James Christopher Edgar
  • Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
    Patent number: 7128895
    Abstract: The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the microvascular permeability assessment is disclosed.
    Type: Grant
    Filed: April 17, 2001
    Date of Patent: October 31, 2006
    Assignees: Bracco Imaging S.p.A., The Regents of the University of California
    Inventors: Friedrich Cavagna, Timothy P. L. Roberts
  • Magnetic resonance imaging method
    Patent number: 6595211
    Abstract: The invention provides a method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, determining the temporal variation in relaxation rate for said signal for at least one region of interest within said lungs, and from said variation generating a qualitative or quantitative value or image indicative of the oxygen uptake from the alveolar space in said at least one region of interest.
    Type: Grant
    Filed: August 2, 2001
    Date of Patent: July 22, 2003
    Assignee: Medi-Physics Inc.
    Inventors: Norbert Weiler, Balthasar Eberle, Wolfgang Schreiber, Klaus Markstaller, Hans-Ulrich Kauczor, Timothy P. L. Roberts, Werner Heil, Reinhard Surkau, Anselm Deninger, Lars Lauer, Tino Grossmann, Michael Ebert
  • Use of bile acid derivatives conjugated with metal ion chelated complexes for the diagnostic assessment of microvascular permeability
    Publication number: 20030103904
    Abstract: The use of contrast agents of molecular weight lower than 5000 Dalton and including at least one residue of a biliary acid for the preparation of diagnostic contrast compositions for the microvascular permeability assessment is disclosed.
    Type: Application
    Filed: October 24, 2002
    Publication date: June 5, 2003
    Inventors: Friedrich Cavagna, Timothy P L Roberts
  • Magnetic resonance imaging method
    Publication number: 20020043267
    Abstract: The invention provides a method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, determining the temporal variation in relaxation rate for said signal for at least one region of interest within said lungs, and from said variation generating a qualitative or quantitative value or image indicative of the oxygen uptake from the alveolar space in said at least one region of interest.
    Type: Application
    Filed: August 2, 2001
    Publication date: April 18, 2002
    Applicant: Medi-Physics Inc.
    Inventors: Norbert Weiler, Balthasar Eberle, Wolfgang Schreiber, Klaus Markstaller, Hans-Ulrich Kauczor, Timothy P.L. Roberts, Werner Heil, Reinhard Surkau, Anselm Deninger, Lars Lauer, Tino Grossmann, Michael Ebert
  • Magnetic resonance imaging method
    Patent number: 6370415
    Abstract: The invention provides a method of detecting regional variations in oxygen uptake from the lungs of an air-breathing animal subject, said method comprising administering into the lungs of said subject a diagnostically effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, detecting the magnetic resonance signal from said agent in said lungs, determining the temporal variation in relaxation rate for said signal for at least one region of interest within said lungs, and from said variation generating a qualitative or quantitative value or image indicative of the oxygen uptake from the alveolar space in said at least one region of interest.
    Type: Grant
    Filed: April 10, 1998
    Date of Patent: April 9, 2002
    Assignee: Medi-Physics Inc.
    Inventors: Norbert Weiler, Balthasar Eberle, Wolfgang Schreiber, Klaus Markstaller, Hans-Ulrich Kauczor, Timothy P. L. Roberts, Werner Heil, Reinhard Surkau, Anselm Deninger, Lars Lauer, Tino Grossmann, Michael Ebert
  • Magnetic resonance experiment and apparatus
    Patent number: 5296809
    Abstract: A magnetic resonance experiment is described in which a sample under test is subjected to a sequence of gradient magnetic fields and RF pulses and resultant pulse echoes are monitored. At least one of the RF pulses comprises a prefocused, phase-modulated, time-asymmetric RF pulse.
    Type: Grant
    Filed: November 4, 1992
    Date of Patent: March 22, 1994
    Inventors: Timothy P. L. Roberts, Thomas A. Carpenter, Laurence D. Hall