Abstract: The present invention provides fusion proteins comprising an extracellular domain of a VEGF receptor and a death ligand. The fusion proteins bind to VEGF and to death receptors on tumor cells thereby inhibiting VEGF activation of VEGF receptors and inducing apoptosis in the tumor cells. Fusion proteins of the present invention are useful for inducing apoptosis and cytotoxic effects in cells, treating cancer and diseases or disorders related to unregulated angiogenesis and/or vasculogenesis. Thus, this invention further provides methods for treating angiogenesis related diseases using the fusion proteins, polynucleotides encoding the fusion proteins, vectors containing the polynucleotides, pharmaceutical compositions and kits containing the fusion proteins or the polynucleotides encoding the fusion proteins.

Abstract: The present invention provides fusion proteins comprising an extracellular domain of a VEGF receptor and a death ligand. The fusion proteins bind to VEGF and to death receptors on tumor cells thereby inhibiting VEGF activation of VEGF receptors and inducing apoptosis in the tumor cells. Fusion proteins of the present invention are useful for inducing apoptosis and cytotoxic effects in cells, treating cancer and diseases or disorders related to unregulated angiogenesis and/or vasculogenesis. Thus, this invention further provides methods for treating angiogenesis related diseases using the fusion proteins, polynucleotides encoding the fusion proteins, vectors containing the polynucleotides, pharmaceutical compositions and kits containing the fusion proteins or the polynucleotides encoding the fusion proteins.

Abstract: In some embodiments, a market assessment system comprises a market opportunity engine, a market capture engine, a comparison engine, and an attainability engine. The market opportunity engine is operable to provide an opportunity measurement for each market of a plurality of markets. The market capture engine operable to provide an actual capture measurement for each market of the plurality of markets. The actual capture measurement indicates an amount of the product actually provided by the enterprise within each market. The comparison engine operable to compare a first market of the plurality of markets to one or more different markets of the plurality of markets to determine one or more comparable markets. The attainability engine operable to calculate an attainable opportunity measurement for the first market based on the actual capture measurement and the opportunity measurement for each of the one or more comparable markets.

Abstract: The present invention provides fusion proteins comprising an extracellular domain of a VEGF receptor and a death ligand. The fusion proteins bind to VEGF and to death receptors on tumor cells thereby inhibiting VEGF activation of VEGF receptors and inducing apoptosis in the tumor cells. Fusion proteins of the present invention are useful for inducing apoptosis and cytotoxic effects in cells, treating cancer and diseases or disorders related to unregulated angiogenesis and/or vasculogenesis. Thus, this invention further provides methods for treating angiogenesis related diseases using the fusion proteins, polynucleotides encoding the fusion proteins, vectors containing the polynucleotides, pharmaceutical compositions and kits containing the fusion proteins or the polynucleotides encoding the fusion proteins.

Abstract: In some embodiments, a market assessment system comprises a market opportunity engine, a market capture engine, a comparison engine, and an attainability engine. The market opportunity engine is operable to provide an opportunity measurement for each market of a plurality of markets. The market capture engine operable to provide an actual capture measurement for each market of the plurality of markets. The actual capture measurement indicates an amount of the product actually provided by the enterprise within each market. The comparison engine operable to compare a first market of the plurality of markets to one or more different markets of the plurality of markets to determine one or more comparable markets. The attainability engine operable to calculate an attainable opportunity measurement for the first market based on the actual capture measurement and the opportunity measurement for each of the one or more comparable markets.

Abstract: The present invention provides fusion proteins comprising an extracellular domain of a VEGF receptor and a death ligand. The fusion proteins bind to VEGF and to death receptors on tumor cells thereby inhibiting VEGF activation of VEGF receptors and inducing apoptosis in the tumor cells. Fusion proteins of the present invention are useful for inducing apoptosis and cytotoxic effects in cells, treating cancer and diseases or disorders related to unregulated angiogenesis and/or vasculogenesis. Thus, this invention further provides methods for treating angiogenesis related diseases using the fusion proteins, polynucleotides encoding the fusion proteins, vectors containing the polynucleotides, pharmaceutical compositions and kits containing the fusion proteins or the polynucleotides encoding the fusion proteins.

Abstract: A method of sensing and controlling an arc welding process employs a high equency rate of sampling of electrical signals from the welding circuit. The sampled signals are operated upon by predetermined processes to determine electrical resistance, shielding gas quality, and short circuit frequency. The process measurements are compared to a predetermined set of tolerance levels and evaluated using a window technique that updates the evaluation of the data samples at the sampling rate.

Abstract: A method and apparatus for preventing catastrophic melting of the contact be in continuously-fed consumable electrode arc welding due to wire feed interruptions by monitoring the movement of the wire electrode with a high frequency sensor such as all optical encoder having a resolution on the order of <0.1 second and switching off the power to the welding apparatus if the wire electrode speed falls below a predetermined threshold.

Abstract: An gas metal arc welding (GMAW) process is monitored by disposing a light intensity sensor in the vicinity of the arc, such that the output signal from the sensor is responsive to the intensity of the arc. The arc light intensity is analyzed to determine the arc length, and to determine of the mode of metal transfer and whether the welding process is proceeding as intended.