Patents by Inventor Timothy P. Tully

Timothy P. Tully has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Screening methods for cognitive enhancers
    Patent number: 9863934
    Abstract: The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunction and for enhancing memory or normal cognitive performance (ability or function) in the animal.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: January 9, 2018
    Assignee: Dart Neuroscience (Cayman) Ltd.
    Inventors: Timothy P. Tully, Roderick E. M. Scott, Rusiko Bourtchouladze
  • Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
    Patent number: 9408830
    Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: August 9, 2016
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Timothy P. Tully, Filippo Cavalieri
  • SCREENING METHODS FOR COGNITIVE ENHANCERS
    Publication number: 20160139111
    Abstract: The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunction and for enhancing memory or normal cognitive performance (ability or function) in the animal.
    Type: Application
    Filed: February 1, 2016
    Publication date: May 19, 2016
    Inventors: Timothy P. Tully, Roderick E.M. Scott, Rusiko Bourtchouladze
  • Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
    Patent number: 9254282
    Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: February 9, 2016
    Assignee: COLD SPRING HARBOR LABORATORY
    Inventors: Timothy P. Tully, Filippo Cavalieri, Rusiko Bourtchouladze
  • Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
    Patent number: 9241925
    Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
    Type: Grant
    Filed: January 10, 2011
    Date of Patent: January 26, 2016
    Assignee: Dart NeuroScience LLC
    Inventors: Timothy P. Tully, Filippo Cavalieri, Rusiko Bourtchouladze
  • AUGMENTED COGNITIVE TRAINING
    Publication number: 20150141441
    Abstract: The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.
    Type: Application
    Filed: January 23, 2015
    Publication date: May 21, 2015
    Inventors: Timothy P. Tully, Filippo Calvalieri
  • SCREENING METHODS FOR COGNITIVE ENHANCERS
    Publication number: 20140342943
    Abstract: The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunction and for enhancing memory or normal cognitive performance (ability or function) in the animal.
    Type: Application
    Filed: June 10, 2014
    Publication date: November 20, 2014
    Inventors: Timothy P. Tully, Roderick E.M. Scott, Rusiko Bourtchouladze
  • Methods, systems, and products for quantitatively measuring the degree of concordance between or among microarray probe level data sets
    Patent number: 8868349
    Abstract: Methods, systems and products are provided to quantitatively measure the degree of concordance between or among microarray probe level data sets. These can include the steps of evaluating outlier probe values, determine gene expression scores, evaluating the significant treatment effect for each gene expression score, and determining concordance between replicate data sets.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: October 21, 2014
    Assignee: Dart Neuroscience (Cayman) Ltd.
    Inventors: Philip Cheung, Timothy P. Tully, Humberto Ortiz-Zuazaga, Oscar Moreno
  • Screening methods for cognitive enhancers
    Patent number: 8771935
    Abstract: The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunction and for enhancing memory or normal cognitive performance (ability or function) in the animal.
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: July 8, 2014
    Assignee: Dart Neuroscience (Cayman) Ltd.
    Inventors: Timothy P Tully, Roderick E. M. Scott, Rusiko Bourtchouladze
  • AUGMENTED COGNITIVE TRAINING
    Publication number: 20130274704
    Abstract: The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.
    Type: Application
    Filed: June 3, 2013
    Publication date: October 17, 2013
    Inventors: Timothy P. Tully, Filippo Cavalieri
  • Augmented cognitive training
    Patent number: 8455538
    Abstract: The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: June 4, 2013
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Timothy P. Tully, Filippo Cavalieri
  • SCREENING METHODS FOR COGNITIVE ENHANCERS
    Publication number: 20120171124
    Abstract: The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunctions and for enhancing memory or normal cognitive performance (ability or function) in a normal animal.
    Type: Application
    Filed: February 2, 2012
    Publication date: July 5, 2012
    Inventors: Timothy P. Tully, Roderick E.M. Scott, Rusiko Bourtchouladze
  • ALTERING MEMORY BY AFFECTING STAUFEN FUNCTION
    Publication number: 20120094916
    Abstract: The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal-dependent cognitive task associated with a defect in STAUFEN.
    Type: Application
    Filed: November 28, 2011
    Publication date: April 19, 2012
    Inventors: Timothy P. Tully, Roderick E.M. Scott, Rusiko Bourtchouladze
  • Screening methods for cognitive enhancers
    Patent number: 8124330
    Abstract: The present invention provides methods for identifying cognitive enhancers able to enhance CREB pathway function. Cognitive enhancers identified in accordance with the invention can be used in rehabilitating an animal with cognitive dysfunctions and for enhancing memory or normal cognitive performance (ability or function) in a normal animal.
    Type: Grant
    Filed: August 19, 2003
    Date of Patent: February 28, 2012
    Assignee: Helicon Therapeutics, Inc.
    Inventors: Timothy P. Tully, Roderick E. M. Scott, Rusiko Bourtchouladze
  • Augmented cognitive training
    Patent number: 8097647
    Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
    Type: Grant
    Filed: June 29, 2006
    Date of Patent: January 17, 2012
    Assignee: Cold Spring Harbor Laboratory
    Inventors: Timothy P. Tully, Filippo Cavalieri
  • Altering memory by affecting staufen function
    Patent number: 8066972
    Abstract: The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or STAUFEN function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating staufen-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation associated with a defect in STAUFEN and methods for treating a defect in performance of a hippocampal-dependent cognitive task associated with a defect in STAUFEN.
    Type: Grant
    Filed: July 15, 2008
    Date of Patent: November 29, 2011
    Assignee: Helicon Therapeutics, Inc.
    Inventors: Timothy P. Tully, Roderick E. M. Scott, Rusiko Bourtchouladze
  • METHODS OF TREATING COGNITIVE DISORDERS BY INHIBITION OF GPR12
    Publication number: 20110281936
    Abstract: The present invention provides methods for screening a pharmaceutical agent for its ability to modulate long term memory formation, performance of a hippocampal-dependent cognitive task or Gpr12 function. The present invention also provides methods for modulating long term memory formation or performance of a hippocampal-dependent cognitive task by modulating Gpr12-dependent protein expression. The present invention further provides methods for treating a defect in long term memory formation by inhibiting Gpr12 function and methods for treating a defect in performance of a hippocampal-dependent cognitive task by inhibiting Gpr12 function.
    Type: Application
    Filed: June 27, 2011
    Publication date: November 17, 2011
    Inventors: Marco Peters, Roderick Euan Milne Scott, Timothy P. Tully
  • AUGMENTED COGNITIVE TRAINING
    Publication number: 20110224146
    Abstract: The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.
    Type: Application
    Filed: May 23, 2011
    Publication date: September 15, 2011
    Inventors: Timothy P. Tully, Filippo Cavalieri
  • AUGMENTED COGNITIVE TRAINING
    Publication number: 20110224287
    Abstract: The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.
    Type: Application
    Filed: May 23, 2011
    Publication date: September 15, 2011
    Inventors: Timothy P. Tully, Filippo Cavalieri
  • PHOSPHODIESESTERASE 4 INHIBITORS FOR THE TREATMENT OF A COGNITIVE DEFICIT
    Publication number: 20110190350
    Abstract: The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.
    Type: Application
    Filed: January 10, 2011
    Publication date: August 4, 2011
    Inventors: Timothy P. Tully, Filippo Cavalieri, Rusiko Bourtchouladze