Abstract: Techniques to facilitate adaptive optimization and control of flotation cell processing are disclosed herein. In at least one implementation, a computing system receives a plurality of flotation cell process variables associated with a flotation cell process. The flotation cell process variables are fed into a machine learning model associated with the flotation cell process to determine improved settings for the flotation cell process. The improved settings for the flotation cell process are provided to an industrial controller that controls at least one aspect of the flotation cell process to improve the flotation cell process.

Abstract: Methods and systems are disclosed herein for updating a knowledge graph based on a user confirmation. A media guidance application receives a user communication and isolates a term of the user communication. The media guidance application identifies a candidate component of a knowledge graph associated with the term. The media guidance application requests user input directed to confirming whether the term is associated with the candidate component. In response to receiving the user input, the media guidance application modifies a strength of association between the term and the component.

Abstract: A system comprises a pressure air data system comprising non-optical air data sensors that interrogate a region of interest outside of a vehicle to determine a first set of air data measurements comprising a first static air pressure. The system also includes an optical air data system comprising optical air data sensors that interrogate the region of interest to determine a second set of air data measurements comprising a second static air pressure. The second static air pressure is determined using conversion coefficients. A processor receives and processes the first static air pressure; receives and processes the second static air pressure; dynamically recalibrates the conversion coefficients by computing a correction factor; sends the correction factor to the optical air data system to update the second static air pressure; and outputs an optimized static air pressure based on the first static air pressure and the updated second static air pressure.

Abstract: In an embodiment, a method is provided. The method comprises selecting at least one set of line of sight (LOS) vectors oriented in one or more directions outward from a vehicle; determining at least one air data solution based on the at least one set of LOS vectors; adjusting at least one value of an air vector equation based on a predetermined quantity; upon adjusting the at least one value, then determining at least one modified air data solution, wherein the at least one modified air data solution is determined based on the at least one set of LOS vectors and the at least one value; and comparing a difference between the at least one air data solution and the at least one modified air data solution to a threshold value, wherein the threshold value is indicative of error with respect to the at least one set of LOS vectors.

Abstract: An air data system comprises a light source that emits a pulsed beam, and an optical transceiver coupled to the light source and configured to receive the pulsed beam. The transceiver is operative to transmit the pulsed beam into an interrogation air region; and receive and collect scattered pulses from the interrogation air region. An optical modulation device is coupled to the transceiver, and is configured to receive the collected scattered pulses from the transceiver and output modulated pulses. An optical detector is coupled to the modulation device and receives the modulated pulses from the modulation device. The modulation device has a nanosecond-based rise/fall time that is synchronized and delayed with respect to the pulsed beam. The modulation device provides for stroboscopic detection of a volume of the interrogation air region based on the modulated pulses received by the detector and having an exposure time of multiple pulse periods.

Abstract: A system comprises an optical air data system that measures aerosol and molecular scattering of light, and an optical instrument that measures aerosol and/or molecular scattering of light. A processor receives data from the air data system and from the optical instrument. The processor performs one or more signal analysis and data fusion methods comprising: (a) determining aerosol and/or molecular concentration from the received data, modifying a data analysis algorithm to optimize any remaining unknown parameters, and outputting enhanced air data parameters; (b) determining aerosol concentration from the received data, dynamically optimizing hardware settings in the air data system to enhance a signal level and avoid system saturation, and outputting enhanced air data parameters; or (c) determining aerosol and/or molecular concentration from the received data, estimating a confidence level of an air data algorithm, verifying optical health of the air data system, and reporting the optical health to a user.

Abstract: Various embodiments of a drug delivery device and a method of using such device are disclosed. The drug delivery device includes a backing layer having a first major surface and a second major surface, and an array of patch segments defined by segment separation lines disposed in the backing layer. Each segment separation line is adapted to enhance separation of one or more patch segments from the array of patch segments. Further, a patch segment of the array of patch segments includes a polygonal shape.

Abstract: Various embodiments of an adhesive article and a method of forming such article are disclosed. The adhesive article includes an active pharmaceutical ingredient; a substrate having a first surface and a second surface including a first area and a second area; and a first adhesive layer disposed on the first area of the second surface of the substrate. The active pharmaceutical ingredient is present in the first adhesive layer at a first concentration. The adhesive article also includes a second adhesive layer having a first portion that is in contact with the first adhesive layer and a second portion that is disposed in the second area of the substrate. The active pharmaceutical ingredient is present in the second adhesive layer at a second concentration. The second concentration is less than the first concentration.

Abstract: Preparations of exosomes and/or Purified Exosome Product (PEP) include antioxidant proteins and antiviral proteins. Compositions that include exosomes and/or PEP can be used to treat subject having, or at risk of having, a condition or tissue damage caused, at least in part, by oxidative stress. Also, compositions that include exosomes and/or PEP can be used to treat subject having, or at risk of having, a viral infection.

Abstract: Film-forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, an amine-rich adhesion promoter, and a volatile solvent. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing. In some cases, the film-forming gel composition can include lidocaine.

Abstract: A tailgate with an integrated grill includes a tailgate body pivotally secured to a rear end of a vehicle. A grill assembly disposed within an interior side of the tailgate body includes a grill grate positioned above a first heating element, a plurality of controls for operating the first heating element, and a pair of compartments positioned adjacent opposing sides of the grill grate. The compartments can be utilized for storing cooking utensils and for other purposes. A fuel supply is secured within a rear storage area of the vehicle. A fuel line coupled to the fuel supply extends through the interior side of the tailgate body and couples to the first heating element. The grill assembly may include additional heating elements such as a gas burners and electric heating elements. The plurality of controls may be utilized to select between different heating elements for different cooking options.

Abstract: A system comprises an optical air data system that measures aerosol and molecular scattering of light, and an optical instrument that measures aerosol and/or molecular scattering of light. A processor receives data from the air data system and from the optical instrument. The processor performs one or more signal analysis and data fusion methods comprising: (a) determining aerosol and/or molecular concentration from the received data, modifying a data analysis algorithm to optimize any remaining unknown parameters, and outputting enhanced air data parameters; (b) determining aerosol concentration from the received data, dynamically optimizing hardware settings in the air data system to enhance a signal level and avoid system saturation, and outputting enhanced air data parameters; or (c) determining aerosol and/or molecular concentration from the received data, estimating a confidence level of an air data algorithm, verifying optical health of the air data system, and reporting the optical health to a user.

Abstract: An air data method and system are disclosed. In one implementation, the method comprises obtaining one or more data measurements from an interrogation region with at least one light detection and ranging (LiDAR) unit along at least one line of sight. The method further comprises sending the one or more data measurements to a processor operative to perform data processing. The data processing includes extracting one or more shock front distances from the one or more data measurements, and calculating one or more shock front angles from the one or more shock front distances. The data processing further includes calculating one or more air data parameters from the one or more shock front angles.

Abstract: In an embodiment, a method is provided. The method comprises selecting at least one set of line of sight (LOS) vectors oriented in one or more directions outward from a vehicle; determining at least one air data solution based on the at least one set of LOS vectors; adjusting at least one value of an air vector equation based on a predetermined quantity; upon adjusting the at least one value, then determining at least one modified air data solution, wherein the at least one modified air data solution is determined based on the at least one set of LOS vectors and the at least one value; and comparing a difference between the at least one air data solution and the at least one modified air data solution to a threshold value, wherein the threshold value is indicative of error with respect to the at least one set of LOS vectors.

Abstract: An air data system comprises a light source that emits a pulsed beam, and an optical transceiver coupled to the light source and configured to receive the pulsed beam. The transceiver is operative to transmit the pulsed beam into an interrogation air region; and receive and collect scattered pulses from the interrogation air region. An optical modulation device is coupled to the transceiver, and is configured to receive the collected scattered pulses from the transceiver and output modulated pulses. An optical detector is coupled to the modulation device and receives the modulated pulses from the modulation device. The modulation device has a nanosecond-based rise/fall time that is synchronized and delayed with respect to the pulsed beam. The modulation device provides for stroboscopic detection of a volume of the interrogation air region based on the modulated pulses received by the detector and having an exposure time of multiple pulse periods.

Abstract: Transdermal patch having at least one pharmaceutically active ingredient and a tamper-evidencing element, as well as methods of making and using the same.

Abstract: An extracellular vesicle includes an exogenous therapeutic component. The exogenous therapeutic component can include a therapeutic polypeptide, a polynucleotide that encodes a therapeutic polypeptide, a therapeutic nucleic acid, or a therapeutic agent. In some embodiments, the extracellular vesicle includes an exosome or purified exosome product (PEP).

Abstract: Silicone-polyether copolymers, adhesives and medical articles comprising same, and methods of making same. The silicone-polyether copolymer composition can include a backbone composition having a first (silicone) segment and a second (polyether) segment connected randomly via at least one of an oxamide linkage and a urea linkage. The method of making the silicone-polyether copolymer composition can include combining: a) a first (silicone) precursor; b) a second (polyether) precursor; and c) at least one of a diisocyanate and an oxalate compound.

Abstract: Silicone-polyether copolymers, adhesives and medical articles comprising same, and methods of making same. The silicone-polyether copolymer composition can include a backbone composition having a first (silicone) segment and a second (polyether) segment connected randomly via at least one of an oxamide linkage and a urea linkage. The method of making the silicone-polyether copolymer composition can include combining: a) a first (silicone) precursor; b) a second (polyether) precursor; and c) at least one of a diisocyanate and an oxalate compound.