Abstract: This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators.

Abstract: A pump includes a conduit defining an inner volume and formed from a flexible material, the conduit movable between an expanded state and a relaxed state. A coil is disposed within the conduit and includes an outer diameter that is approximately equal to an inner diameter of the conduit, the coil substantially maintaining its outer diameter when the conduit is moved between the relaxed state and the expanded state. A manifold is in fluid communication with the inner volume and is operable to permit fluid to enter the inner volume in a first mode and expel fluid from the inner volume in a second mode.

Abstract: A multi-port antenna and associated systems having extremely wide bandwidth and capable of maintaining directivity as frequency decreases and is made arbitrarily low, allowing DF systems to operate to arbitrarily low frequency regardless of size. Construction may be rugged, lightweight, and low cost, allowing reliable service in harsh environments. The systems allow utilization of both the E and H fields occupying a common area of space. The disclosed DF system takes advantage of knowledge of the as-installed array manifold, uses pattern matching to determine the angle of arrival (AoA) of incoming waves, and enhances sensitivity by using integration on cross-correlation products between the multiple ports to achieve SNR improvement.

Abstract: A multi-port antenna and associated systems having extremely wide bandwidth and capable of maintaining directivity as frequency decreases and is made arbitrarily low, allowing DF systems to operate to arbitrarily low frequency regardless of size. Construction may be rugged, lightweight, and low cost, allowing reliable service in harsh environments. The systems allow utilization of both the E and H fields occupying a common area of space. The disclosed DF system takes advantage of knowledge of the as-installed array manifold, uses pattern matching to determine the angle of arrival (AoA) of incoming waves, and enhances sensitivity by using integration on cross-correlation products between the multiple ports to achieve SNR improvement.

Abstract: An assembly process for assembling a basin using a molding tool operable between an open position and a closed position, the molding tool having a female molding insert, a male molding insert, and an insert jig, the female molding insert and the male molding insert cooperating to define a mold cavity when the molding tool is in the closed position, the female molding insert having an aperture, the insert jig having a sleeve and a cylinder, the cylinder repositionable within the sleeve and having an end with an end face and a pin protruding from the end face, includes applying adhesive to the pin. The assembly process also includes aligning the pin with an aperture of a basin rim insert. The assembly process also includes pressing the basin rim insert towards the end face such that the pin is received within the aperture of the basin rim insert.

Abstract: A multi-port antenna and associated systems having extremely wide bandwidth and capable of maintaining directivity as frequency decreases and is made arbitrarily low, allowing DF systems to operate to arbitrarily low frequency regardless of size. Construction may be rugged, lightweight, and low cost, allowing reliable service in harsh environments. The systems allow utilization of both the E and H fields occupying a common area of space. The disclosed DF system takes advantage of knowledge of the as-installed array manifold, uses pattern matching to determine the angle of arrival (AoA) of incoming waves, and enhances sensitivity by using integration on cross-correlation products between the multiple ports to achieve SNR improvement.

Abstract: A multiport antenna in which the antenna conductive elements are arranged to form an at least partially enclosed volume which can accommodate an enclosure containing one or more electronic components, or optical components, or optoelectronic components, or a combination of these. The enclosure may also be provided with a conductive transparent window which permits optical components to receive and/or send optical information.

Abstract: A multiport antenna in which the antenna conductive elements are arranged to form an at least partially enclosed volume which can accommodate an enclosure containing one or more electronic components, or optical components, or optoelectronic components, or a combination of these. The enclosure may also be provided with a conductive transparent window which permits optical components to receive and/or send optical information.

Abstract: A multiport antenna in which the antenna conductive elements are arranged to form an at least partially enclosed volume which can accommodate an enclosure containing one or more electronic components, or optical components, or optoelectronic components, or a combination of these. The enclosure may also be provided with a conductive transparent window which permits optical components to receive and/or send optical information.

Abstract: A multi-port antenna and associated systems having extremely wide bandwidth and capable of maintaining directivity as frequency decreases and is made arbitrarily low, allowing DF systems to operate to arbitrarily low frequency regardless of size. Construction may be rugged, lightweight, and low cost, allowing reliable service in harsh environments. The systems allow utilization of both the E and H fields occupying a common area of space. The disclosed DF system takes advantage of knowledge of the as-installed array manifold, uses pattern matching to determine the angle of arrival (AoA) of incoming waves, and enhances sensitivity by using integration on cross-correlation products between the multiple ports to achieve SNR improvement.

Abstract: An electromagnetic transmission system is provided, comprising: M chirp generators, each operating at a first frequency, each of the M chirp generators being configured to generate an ith digital chirp portion comprising (1/M)th of a digital chirp signal having a set ramp rate; a parallel-in serial-out register configured to receive the M digital chip portions in parallel at the first frequency, and configured to output the M digital chip portions in series as the digital chirp signal at a second frequency; and a digital-to-analog converter operating at the second frequency and configured to convert the digital chirp signal into an analog chirp signal, wherein i is an index that goes from 1 to M, and wherein the second frequency is M times the first frequency.

Abstract: A heated portable collapsible chair includes a collapsible frame. The collapsible frame supports a fabric human contact sheet having a chair seat portion and a chair back portion. A flexible heating element is located adjacent to a back surface of the human contact sheet so that heat generated by the heating element passes through the human contact sheet to warm a user. A battery is provided for selectively heating the heating element. The flexible heating element is preferably affixed to a backing sheet wherein the backing sheet is affixed to the back surface of the human contact sheet. The flexible heating element accommodates the flexing of the human contact sheet when the human contact sheet is distorted when collapsing the chair for storage or transport.

Abstract: An electromagnetic transmission system is provided, comprising: M chirp generators, each operating at a first frequency, each of the M chirp generators being configured to generate an ith digital chirp portion comprising (1/M)th of a digital chirp signal having a set ramp rate; a parallel-in serial-out register configured to receive the M digital chip portions in parallel at the first frequency, and configured to output the M digital chip portions in series as the digital chirp signal at a second frequency; and a digital-to-analog converter operating at the second frequency and configured to convert the digital chirp signal into an analog chirp signal, wherein i is an index that goes from 1 to M, and wherein the second frequency is M times the first frequency.

Abstract: A heated portable collapsible chair includes a collapsible frame. The collapsible frame supports a fabric human contact sheet having a chair seat portion and a chair back portion. A flexible heating element is located adjacent to a back surface of the human contact sheet so that heat generated by the heating element passes through the human contact sheet to warm a user. A battery is provided for selectively heating the heating element. The flexible heating element is preferably affixed to a backing sheet wherein the backing sheet is affixed to the back surface of the human contact sheet. The flexible heating element accommodates the flexing of the human contact sheet when the human contact sheet is distorted when collapsing the chair for storage or transport.

Abstract: A method of treating a cardiomyopathy in a subject includes administering directly to or expressing locally in a weakened, ischemic, and/or peri-infarct region of myocardial tissue of the subject an amount of SDF-1 effective to cause functional improvement in at least one of the following parameters: left ventricular volume, left ventricular area, left ventricular dimension, cardiac function, 6-minute walk test, or New York Heart Association (NYHA) functional classification.

Abstract: An equalizer is provided, including: a feedback combiner to combine an input signal and a feedback signal to produce a first signal; a delay line to delay the first signal to produce a second signal; a feed-forward combiner to combine the second signal and a feed-forward signal to produce an output signal; an interim decision circuit to extract a sign bit from the first signal; N feedback scaling elements to generate N scaled feedback signals; M feed-forward scaling elements to generate M scaled feed forward signals; a feedback circuit to pass the N scaled feedback signals through feedback delay elements and feedback summing elements to generate the feedback signal in response to the sign bit; and a feed forward circuit to pass the M scaled feed forward signals through feed-forward delay elements and feed-forward summing elements to generate the feed-forward signal in response to the sign bit.

Abstract: A receiver circuit (200) is provided, comprising: an agile clock (250) configured to generate an agile clock signal having a controllable agile clock phase based on agile clock control signals; a code processor (260) configured to receive an incoming signal and the agile clock signal, and to generate an on-time signal (110) and an error signal (120) corresponding to the incoming signal; a coarse acquisition circuit (270, 310) configured to identify a coarse acquisition phase based on a total power of the on-time signal and plus a total power of the error signal; a fine acquisition circuit (270, 320) configured to identify a fine acquisition phase based on the coarse acquisition phase and a magnitude of the on-time signal; and an acquisition controller (270, 330) configured to control operation of the coarse acquisition circuit and the fine acquisition circuit, and to provide a final acquisition phase as a current phase based on the one or more fine acquisition phases.

Abstract: A method is provided for transmitting data. A first device generates a first signal having a first duty cycle, comprising a first gated-on portion and a first gated-off portion in a time slot; and a second device generates a second signal having second duty cycle, comprising a second gated-on portion and a second gated-off portion in the same time slot. The first gated-on portion is generated during a first segment of the time slot and the first gated-off portion is generated during a second segment of the time slot, while the second gated-on portion is generated during the second segment and the second gated-off portion is generated during the first segment. Media access control (MAC) can be used to further define positions within time slots and provide error correction, power control, and the like. A preamble can be transmitted at an increased power level to facilitate acquisition.