Abstract: Disclosed is a registration object for computed radiographic tomography. The object has a body portion defining a void for including at least part of a target object. The registration object comprises one or more relatively radiopaque or relatively radiolucent features. Said feature or features provide, in a suitable proportion of radiographic projections of the registration object with respect to angle about a predetermined axis, a pair of identifiable registration points which are spaced apart in a direction parallel to the predetermined axis by a first distance, and whose positions in that direction are each either a constant or a function only of the angle of the projection about the predetermined axis.

Abstract: Provided herein are genetic markers for predicting response to antipsychotic treatment. Genotyping of the disclosed SNPs can be used to predict response to antipsychotic drugs in patients suffering from schizophrenia. There is provided method of treating a subject with an antipsychotic medication comprising obtaining genetic information from the subject comprising the sequence of SNPs rs6923761, rs2300615, and rs1042044 to provide the GLP1 R Antipsychotic Response Phenotype (GARP) genetic signature of the subject; and administering an antipsychotic medication to the subject based on the GARP genetic signature of the subject.

Abstract: Disclosed is a registration object for computed radiographic tomography. The object has a body portion defining a void for including at least part of a target object. The registration object comprises one or more relatively radiopaque or relatively radiolucent features. Said feature or features provide, in a suitable proportion of radiographic projections of the registration object with respect to angle about a predetermined axis, a pair of identifiable registration points which are spaced apart in a direction parallel to the predetermined axis by a first distance, and whose positions in that direction are each either a constant or a function only of the angle of the projection about the predetermined axis.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR and PDGFR kinases.

Abstract: The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFR and PDGFR kinases.

Abstract: This invention relates to compounds of the formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.

Abstract: This application discloses compounds that inhibit Raf kinase having the formula (I), wherein R1 is a phenyl radical or a heteroaryl radical; and R2 is a phenyl radical; or an N-oxide or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of proliferative diseases, such as cancer.

Abstract: The invention relates to phenyl-[4-(3-phenyl-1H-pyrazol-4-yl)-pyrimidin-2-yl]-amine derivatives and to processes for the preparation thereof, to pharmaceutical compositions comprising such derivatives and to the use of such derivatives—alone or in combination with one or more other pharmaceutically active compounds—for the preparation of pharmaceutical compositions for the treatment especially of a proliferative disease, such as a tumour.

Abstract: The present invention relates to certain substituted polyketides of formula I, wherein A, B and C are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

Abstract: The present invention relates to certain substituted polyketides of formula I, wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

Abstract: A method for creating a multimedia presentation, which presentation comprises an audio or video recording of a session wherein a presenter presents an audiovisual presentation, said method comprising said presenter presenting said audiovisual presentation, making an audio or video recording of said presentation, wherein timing data comprising data for start, end and transition events within said audiovisual presentation are automatically, and without manual processing, incorporated into said audio or video recording, so as to allow said events to be used on playback to coordinate the audio or video portion of said multimedia presentation with the audiovisual portion thereof.

Abstract: A high-performance, adaptive and scalable system for distributing streaming media, in which processing into a plurality of output formats is controlled in a real-time distributed manner, and which further incorporates processing improvements relating to workflow management, video acquisition and video preprocessing. The processing system may be used as part of a high-speed content delivery system in which such streaming media processing is conducted at the edge of the network, allowing video producers to supply improved live streaming experience to multiple simultaneous users independent of the users' individual viewing device, network connectivity, bit rate and supported streaming formats. Methods by which such system may be used to commercial advantage are also described.