Abstract: The present disclosure provides methods, systems, compositions, and kits for the high-throughput detection of multi-molecule biomarkers in a biological sample. The disclosed methods, systems, compositions, and kits utilize antibody-oligonucleotide tags to detect two or more molecules that are in close proximity.

Abstract: The present disclosure provides methods, systems, compositions, and kits for the high-throughput detection of multi-molecule biomarkers in a biological sample. The disclosed methods, systems, compositions, and kits utilize antibody-oligonucleotide tags to detect two or more molecules that are in close proximity.

Abstract: The present disclosure provides methods, systems, compositions, and kits for the high-throughput detection of multi-molecule biomarkers in a biological sample. The disclosed methods, systems, compositions, and kits utilize antibody-oligonucleotide tags to detect two or more molecules that are in close proximity.

Abstract: Disclosed herein are systems, methods, and compositions for treating a subject diagnosed with, or suffering from cancer. In some embodiments, the method comprises determining whether a tumor sample from the subject includes a cytotoxic gene signature, and treating the subject based on the determination. In some embodiments, the subject has or is suspected of having a loss of heterozygosity in human leukocyte antigen (HLA) class I genes. In some embodiments, the therapy comprises one or more checkpoint inhibitors. In some embodiments, the cancer is colorectal, uterine, stomach, lung, skin, head or neck, or non-small cell lung carcinoma.

Abstract: Systems and methods for applying both profile and user customizations to an application user interface are provided. Profile customizations, created for a specialized use or field, are adapted to an application user interface, which has command-menu-toolbar contributions from various add-in modules. The user has access to the customizations through a user interface. Then, as a user is customizing the application, through commands, toolbars, and menus, the user customizations are tagged. A priority and group is assigned to each customization to allow for relative positioning of each customization. The difference between the user's final desired state and a reset state is computed. This difference computation is used to track the changes made to the application and to assist in resets of the customizations.

Abstract: The aforementioned need is satisfied by the present invention in which a help architecture supports an application and a help engine operating on a computer, where the help engine is for locating help topics relevant to the application. In the help architecture, at least one help library stores a plurality of help topics therein, where the help topics are accessible to a user from the help library by way of the computer, and a central store stores topic metadata corresponding to help topics available from each help library. The central store in response to a search request from the help engine locates topic metadata relevant to the search request and returns information from the located topic metadata.

Abstract: A device and method are provided for determining the wear of a sole of a shoe. The device includes first and second sensors receivable in the sole of the shoe. The sensors are axially spaced and generate signals in response to corresponding impact forces acting thereon. A control circuit is connectable to the first and second sensors. The control circuit compares the difference between the first and second signals to a threshold and generates an alert signal in response to the difference between the first and second signal meeting the threshold.

Abstract: An application and a context-based help system operate on a computer. The application includes a plurality of components that effectuate application functions, where each component of the application is constructed to describe a current context of the component representative of a current state of the component. At least some of the components are active at any one time. The help system includes a help engine that receives the current context from each active component, dynamically builds a current overall context of the application based on each received current context, locates help topics based on the current overall context, and filters and prioritizes the located help topics.

Abstract: The aforementioned need is satisfied by the present invention in which a help architecture supports an application and a help engine operating on a computer, where the help engine is for locating help topics relevant to the application. In the help architecture, at least one help library stores a plurality of help topics therein, where the help topics are accessible to a user from the help library by way of the computer, and a central store stores topic metadata corresponding to help topics available from each help library. The central store in response to a search request from the help engine locates topic metadata relevant to the search request and returns information from the located topic metadata.

Abstract: An application and a context-based help system operate on a computer. The application includes a plurality of components that effectuate application functions, where each component of the application is constructed to describe a current context of the component representative of a current state of the component. At least some of the components are active at any one time. The help system includes a help engine that receives the current context from each active component, dynamically builds a current overall context of the application based on each received current context, locates help topics based on the current overall context, and filters and prioritizes the located help topics.