Abstract: Provided herein are methods of delivering a low viscosity fluid to a targeted sub-region of a subject's nasal cavity via delivery as a continuous liquid stream.

Abstract: The present disclosure describes intranasal knockout bolus formulations, methods, and devices. Olfactory delivery of a therapeutic agent via an intranasal bolus of the therapeutic agent may be reduced or terminated by precision delivery of a knockout bolus of a purging formulation. The knockout bolus may be delivered at a velocity sufficient to physically displace the therapeutic agent from an olfactory cleft, may dilute the intranasal bolus of a therapeutic formulation, or may cause an osmotic pressure sufficient to reverse a direction of a drug flow through a tissue of the olfactory cleft. An ability to modulate or stop delivery of the therapeutic agent via the olfactory cleft allows for more precision dosing and more control of dose timing in response to biometric monitoring.

Abstract: The present disclosure describes formulations, methods, and devices tor biomarker sampling and therapeutic delivery using magnetic formulations. When combined with the application of external magnetic fields, magnetic formulations move within the nasal cavity. Magnetic formulations provide benefits including the ability to: target or steer placement of the formulations via a magnetic field, enhance mixing of the formulation via a magnetic field, enhance biological material collection via antibody-coated magnetic beads, or enhance sample retrieval via a magnetic-tipped inserter. Example biological materials for collection include proteins, enzymes, neural stem cells, and other biomarkers.

Abstract: Provided herein are methods of delivering a low viscosity fluid to a targeted sub-region of a subject's nasal cavity via delivery as a continuous liquid stream.

Abstract: The present disclosure describes formulations, methods, and devices for intranasal delivery to a subject. The formulations may form two fluids which are immiscible at intranasal environmental conditions, such that when a formulation is delivered to a nasal cavity the two fluids separate with the more dense of the fluids settling below the less dense of the two fluids. One or more of the two fluids may concentrate a therapeutic agent or sampling fluid against a selected portion of the nasal cavity and the more dense of the two fluids can increase retention time of the formulation within the nasal cavity. Devices of the present disclosure may provide a convenient and effective way to deliver dual-density formulations intranasally.

Abstract: Provided herein are methods of delivering a low viscosity fluid to a targeted sub-region of a subject's nasal cavity via delivery as a continuous liquid stream.

Abstract: An isolator performance data logging system comprising a displacement unit for measuring a displacement of the isolator. the displacement unit comprises a displacement sensor housing fixable relative to a mitigated end of the isolator, a target fixable relative to an unmitigated end of the isolator. A displacement sensor is located within the displacement sensor housing for measuring a displacement of the target relative to the displacement sensor. A first accelerometer unit is fixable relative to the mitigated end of the isolator. A second accelerometer unit is fixable relative to the unmitigated end of the isolator.

Abstract: An isolator performance data logging system comprising a displacement unit for measuring a displacement of the isolator. the displacement unit comprises a displacement sensor housing fixable relative to a mitigated end of the isolator, a target fixable relative to an unmitigated end of the isolator. A displacement sensor is located within the displacement sensor housing for measuring a displacement of the target relative to the displacement sensor. A first accelerometer unit is fixable relative to the mitigated end of the isolator. A second accelerometer unit is fixable relative to the unmitigated end of the isolator.

Abstract: A suspension system has an isolator cylinder with a primary reservoir having a primary reservoir volume, a secondary reservoir having a secondary reservoir volume, a manifold and a primary duct fluidly connecting the primary and secondary reservoirs for controlling the flow rate of the fluid between the primary and secondary reservoirs, and optionally a valve for controlling a flow rate of a fluid through the duct, and a control system for operating the valve. A shock absorption system for a vehicle seat is provided comprising an isolator with at least one secondary pneumatic reservoir connected with a fluid duct to the primary reservoir of an isolator. The reservoir volumes, length and cross sectional area of the connecting duct and fluid flow control valves may be determined using methods including algorithms, experimental testing and models to determine the optimal values to achieve consistent shock mitigation across a range of seat loads.