Abstract: The present patent application discloses the compounds according to Formula I shown below, or pharmaceutically acceptable salts thereof, wherein JB, n, R1, R2, R3, R4, R5, m and X as defined herein.

Abstract: Provided herein are compositions, systems, and methods comprising effector proteins, effector partners, and uses thereof. These effector proteins may be characterized as CRISPR-associated (Cas) proteins. Various compositions, systems, and methods of the present disclosure may leverage the activities of these effector proteins for the modification, detection, and/or engineering of nucleic acids.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training an action selection neural network used to select actions to be performed by an agent interacting with an environment. In one aspect, a system comprises a plurality of actor computing units and a plurality of learner computing units. The actor computing units generate experience tuple trajectories that are used by the learner computing units to update learner action selection neural network parameters using a reinforcement learning technique. The reinforcement learning technique may be an off-policy actor critic reinforcement learning technique.

Abstract: A spindle nut retainer is used with a spindle with a flat portion on its threaded end. The flat portion interrupts the threads on the threaded end. A washer with a mating flat portion is slidably mounted over the threaded end and a nut is removably threaded to the threaded end of the spindle against the washer to set the preload on bearings. The nut retainer overlays a plurality of the corners of the nut and engages the threaded portion of the spindle with tangs. A majority of the tangs are flexed or bent to remain in biased contact with the threads on the spindle. Some of the tangs are located over the flat portion and remain unbent. The tangs resist rotation of the nut by engagement with the flat portion where it meets the threads.

Abstract: A digital security system can store data associated with entities in resolver trees. If the digital security system determines that two resolver trees are likely representing the same entity, the digital security system can use a merge operation to merge the resolver trees into a single resolver tree that represents the entity. The single resolver tree can include a merge node indicating a merge identifier of the merge operation. Nodes containing information merged into the resolver tree from another resolver tree during the merge operation can be tagged with the corresponding merge identifier. Accordingly, if the merge operation is to be undone, for instance if subsequent information indicates that the entries are likely separate entities, the resolver tree can be unmerged and the nodes tagged with the merge identifier can be restored to a separate resolver tree.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: Adapting automatic software update behavior for virtual desktop infrastructure deployed endpoints includes detecting a request for services of a threat management facility for an enterprise network that originates from a compute instance embodied as a virtual machine instantiated from a versioned software template, and updating software on the compute instance based on a determination of availability of updated software for the compute instance and an update pause parameter indicating that updating software for virtual machines instantiated from the versioned software template is permitted for the compute instance.

Abstract: Snares for retrieval of medical devices from the body of an animal, medical assemblies, kits, and methods of retrieving a medical device from the body of an animal are described. An example snare comprises an outer sheath defining an outer sheath lumen; an elongate member disposed in the outer sheath lumen and having a longitudinal axis and at least one elongate member lumen; a capture member disposed and axially movable within the at least one elongate member lumen, the capture member defining a capture loop having a throat region and a portion extending along a plane that is perpendicular to the longitudinal axis of the elongate member; and a threader member disposed and axially movable within the at least one elongate member lumen, the threader member defining a threader loop. A handle includes a rotatable control member for deflecting a distal end of the outer sheath.

Abstract: A circuit board assembly includes a circuit board and an electrical connector having a connector housing holding contacts in a contact array. The connector housing has a mating end configured to be mated with a mating electrical connector in a mating direction. The electrical connector has cables terminated to the contacts and extending from a cable end. A connector mount is used to locate the electrical connector relative to the circuit board. A bracket is coupled to the mounting surface of the circuit board. A biasing member is coupled to the bracket and the mounting feature and is compressible along a compression axis parallel to the mating direction to allow the electrical connector to float in the mating direction relative to the circuit board.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: A method including detecting that a vehicle that may be propelled by an electric drive system having one or more motors disconnects or begins disconnecting from an off-board source of power while the one or more motors are being powered by the off-board source of power. The method may include supplanting a decreasing amount of a first electric energy supplied by the off-board source of power to the electric drive system with an amount of a second electric energy supplied by an onboard source of power to the electric drive system responsive to the detection of the disconnect from the off-board source of power.

Abstract: An anti-collision system for railcars and locomotives provides a distance ranging and worker coupling protection system utilizing remote-sensing radar techniques for use with a locomotive and railcar. The anti-collision system may include an object detector device attached to a railcar or a locomotive that detects objects in a path of the railcar and the locomotive and a train display device electrically connected to the object detector device. The anti-collision system may also include an emergency action device which enables a crew member to stop the railcar or locomotive without communication to a locomotive operator when a hazard is recognized. The object detector device may include a remote sensor, a radio, and a microprocessor programmed to include data-logging to record and log all data from the anti-collision system.

Abstract: Techniques for employing a smart sensor device that has a primary sensing function for sensing a state of a physical component and can concurrently enable one or more backup functions for sensing one or more states of one or more other physicals components in response to one or more other smart sensor devices not being able to perform their primary function of sensing and/or reporting on the one or more states of the one or more other physical components.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for measuring and reporting calibration accuracy of robots and sensors assigned to perform a task in an operating environment. One of the methods includes receiving a request to perform a calibration process for one or more robots in an operating environment; in response, performing the calibration process including executing a calibration program that generates movement data representing movements by the one or more robots within the operating environment; computing a measure of calibration accuracy from the movement data; receiving an input program to be executed in the operating environment; determining that the measure of calibration accuracy does not satisfy an accuracy tolerance of the input program; and in response, generating a notification representing that the measure of calibration accuracy generated from performing the calibration process does not satisfy the accuracy tolerance of the input program.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A speaker can have a main body with a generally spheroidal shape, which can be supported standing on its end. The speaker can include a subwoofer that faces forward. A plurality of mid-range drivers can be distributed around the sub-woofer, facing generally forward and radially outward. A plurality of tweeters can be distributed around the sub-woofer, facing generally forward and generally outward. The outer housing portion of the speaker can be covered with a fabric material. A user interface ring 162 can be touch sensitive to receive input, and can have a plurality of lights that can be illuminated separately to convey information to the user.

Abstract: Systems and methods for using stratigraphic heat maps to steer a well being drilled. Data from one or more offset wells can be provided to a computer system and used with data from a well being drilled to generate one or more stratigraphic heat maps during the drilling of the subject well. The stratigraphic heat maps can be displayed and used to determine the location of the wellbore relative to one or more geological formations, including one or more target formations or within a target formation. Based on the use of the heat maps and the location of the wellbore relative to a target, the drill plan can be adjusted or updated and/or one or more drilling parameters or operations may be adjusted to drill the wellbore, such as to drill the wellbore to the target or to maximize the length of the wellbore within a target zone.

Abstract: Systems and methods for purposeful computing are disclosed that, among other things, include a user purpose class resource information computing environment. Such environment supports resource purpose classes, and further supports resource identification information sets that characterize their respective subject matter resources. The computing environment can be used to identify and evaluate one or more purpose class subject matter resource members.

Abstract: A circuit board assembly includes an electrical connector mounted to a circuit board having a connector housing holding contacts in a contact array. A connector mount having a bracket is coupled to the mounting surface of the circuit board proximate to the mating edge. The electrical connector is movably coupled to the connector mount to move relative to the circuit board during mating with the mating electrical connector. The connector mount has a biasing member compressible along a compression axis parallel to the mating direction to allow the electrical connector to float in the mating direction relative to the circuit board. The electrical connector is movably coupled to the connector mount in a confined envelope in at least one floating direction perpendicular to the mating direction.

Abstract: A method of printing a 3D part with an additive manufacturing system includes printing a first portion of the part and pre-heating the first portion of the part along an upcoming tool path to a temperature at or above a material-specific bonding temperature and below a degradation temperature of the material. Material is extruding material onto the first portion along the pre-heated tool path while the temperature along the part surface remains at or above a material-specific bonding temperature and below the degradation temperature of the material thereby forming a newly extruded road. The method includes cooling the newly extruded road along the pre-heated tool path to remove heat imparted by the preheating step such that a thermally stable temperature is reached, wherein the preheating, extruding and cooling is performed in less than ten seconds.