Patents by Inventor Timothy Shepherd
Timothy Shepherd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220249869Abstract: Methods, systems, and apparatuses are disclosed for radiation treatment of tumors based at least in part on patient-specific imaging information. The methods, systems and apparatuses include computer programs encoded on computer-readable media. The methods include acquiring imaging information relating to a target to be treated. The imaging information is non-anatomic imaging information relating to the target acquired from at least one imaging marker that reflects at least one of the metabolic, physiological and histological features of the target. The methods further include computing a radiation dose based at least on the imaging information.Type: ApplicationFiled: February 21, 2022Publication date: August 11, 2022Applicant: NEW YORK UNIVERSITYInventors: Douglas KONDZIOLKA, Timothy SHEPHERD
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Patent number: 11253726Abstract: Methods, systems, and apparatuses are disclosed for radiation treatment of tumors based at least in part on patient-specific imaging information. The methods, systems and apparatuses include computer programs encoded on computer-readable media. The methods include acquiring imaging information relating to a target to be treated. The imaging information is non-anatomic imaging information relating to the target acquired from at least one imaging marker that reflects at least one of the metabolic, physiological and histological features of the target. The methods further include computing a radiation dose based at least on the imaging information.Type: GrantFiled: April 20, 2017Date of Patent: February 22, 2022Assignee: New York UniversityInventors: Douglas Kondziolka, Timothy Shepherd
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Patent number: 10966694Abstract: A primary sample holder for imaging, gross pathology, or histological correlations of a biological sample includes an enclosure having a first side wall, a second side wall, and a bottom wall; a plurality of slots provided at predetermined intervals along the first and second side walls; and a grid recessed within the bottom wall. The grid includes a hole bisected by a central panel and at least one axial panel that intersects the central panel along a length thereof. The biological sample received by the primary sample holder is configured to be aligned with the central panel of the grid to align the biological sample along an accepted internal orientation line (e.g., the anterior-posterior commissure line in the brain). The slots are configured to receive a cutting device to cut the biological sample into slices of uniform thickness containing a region of interest based on histological and imaging findings.Type: GrantFiled: June 28, 2018Date of Patent: April 6, 2021Assignee: NEW YORK UNIVERSITYInventors: Timothy Shepherd, Ryan Brown, Mary Bruno
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Publication number: 20190000431Abstract: A primary sample holder for imaging, gross pathology, or histological correlations of a biological sample includes an enclosure having a first side wall, a second side wall, and a bottom wall; a plurality of slots provided at predetermined intervals along the first and second side walls; and a grid recessed within the bottom wall. The grid includes a hole bisected by a central panel and at least one axial panel that intersects the central panel along a length thereof. The biological sample received by the primary sample holder is configured to be aligned with the central panel of the grid to align the biological sample along an accepted internal orientation line (e.g., the anterior-posterior commissure line in the brain). The slots are configured to receive a cutting device to cut the biological sample into slices of uniform thickness containing a region of interest based on histological and imaging findings.Type: ApplicationFiled: June 28, 2018Publication date: January 3, 2019Inventors: Timothy SHEPHERD, Ryan BROWN, Mary BRUNO
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Publication number: 20180303559Abstract: An electronic position guidance device is configured to attach to a medical device having a first end configured for percutaneous insertion and a second end configured to remain exterior to a patient's skin. The device includes an orientation attachment configured to detect an orientation and a position of the medical device, a processor configured to receive orientation and position information from the orientation attachment and determine a degree to which an actual insertion angle of the medical device deviates from a target angle and/or a degree to which an actual insertion depth of the medical device deviates from a target insertion depth, a display configured to visually convey to a user, in real-time via graphic, text and/or color, the orientation and the position of the medical device, and a speaker configured to audibly convey to the user, in real-time via sound, the orientation and the position of the medical device.Type: ApplicationFiled: October 18, 2016Publication date: October 25, 2018Inventors: Timothy SHEPHERD, Nainesh PARIKH, Peter THELWALL
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Publication number: 20170216624Abstract: Methods, systems, and apparatuses are disclosed for radiation treatment of tumors based at least in part on patient-specific imaging information. The methods, systems and apparatuses include computer programs encoded on computer-readable media. The methods include acquiring imaging information relating to a target to be treated. The imaging information is non-anatomic imaging information relating to the target acquired from at least one imaging marker that reflects at least one of the metabolic, physiological and histological features of the target. The methods further include computing a radiation dose based at least on the imaging information.Type: ApplicationFiled: April 20, 2017Publication date: August 3, 2017Inventors: Douglas KONDZIOLKA, Timothy SHEPHERD
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Patent number: 8309363Abstract: An apparatus (10) for evaluating a liquid hydrocarbon to determine the propensity for coke formation comprising an injector (12), a supply of air (14) arranged to supply air to the injector (12) and a supply of liquid hydrocarbon (16) arranged to supply liquid hydrocarbon to the injector (12). The injector (12) is arranged to atomise the liquid hydrocarbon and to supply the air and atomised liquid hydrocarbon into a chamber (18) and the chamber (18) is arranged to supply atomised liquid hydrocarbon and air to a test pipe (20) and a heater (22) is arranged to heat the test pipe (20). The test pipe (20) is pivotably mounted on a frame (28) such that the orientation of the test pipe (20) relative to the frame (28) is variable. The apparatus (10) is able to simulate conditions within a vent pipe of a lubricant system of an aero gas turbine engine.Type: GrantFiled: May 11, 2009Date of Patent: November 13, 2012Assignee: Rolls-Royce PLCInventors: John S Askins, Timothy A Shepherd
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Publication number: 20090305428Abstract: An apparatus (10) for evaluating a liquid hydrocarbon to determine the propensity for coke formation comprising an injector (12), a supply of air (14) arranged to supply air to the injector (12) and a supply of liquid hydrocarbon (16) arranged to supply liquid hydrocarbon to the injector (12). The injector (12) is arranged to atomise the liquid hydrocarbon and to supply the air and atomised liquid hydrocarbon into a chamber (18) and the chamber (18) is arranged to supply atomised liquid hydrocarbon and air to a test pipe (20) and a heater (22) is arranged to heat the test pipe (20). The test pipe (20) is pivotably mounted on a frame (28) such that the orientation of the test pipe (20) relative to the frame (28) is variable. The apparatus (10) is able to simulate conditions within a vent pipe of a lubricant system of an aero gas turbine engine.Type: ApplicationFiled: May 11, 2009Publication date: December 10, 2009Applicant: ROLLS-ROYCE PLCInventors: John S. Askins, Timothy A. Shepherd
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Patent number: 7486071Abstract: A fluid monitoring arrangement 1 for an engine is operated in accordance with a method whereby nuclear magnetic resonance (NMR) interrogation of the fluid flow 3 it is possible to determine whether appropriate fluids and additives are being utilised as well as whether potential detrimental actions occur such as engine wear and carbonisation through particulate components within the flow 3. Generally, an expected signal response from the fluid flow 3 is determined and the actual signal response compared in a comparator 8 with that expected signal response. Divergence in the actual signal response and in particular with regard to its profile is identified and an indication provided in a display 10 with regard to the potential coolant of such divergence. Normally, a reference library 11 is provided of expected signal responses for comparison in the comparator with the actual signal responses.Type: GrantFiled: July 7, 2004Date of Patent: February 3, 2009Assignee: Rolls-Royce plcInventors: Ian C D Care, Timothy A Shepherd
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Publication number: 20070225267Abstract: The present invention provides BACE inhibitors of Formula (I); methods for their use and preparation, and intermediates useful for their preparation.Type: ApplicationFiled: September 20, 2005Publication date: September 27, 2007Inventors: Howard Broughton, Robert Dally, Timothy Durham, Maria Rosario Gonzalez-Garcia, Lilly Sa, Patric Hahn, Kenneth Henry, Todd Kohn, James McCarthy, Timothy Shepherd, Jon Erickson, Ana Bueno Melendo
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Publication number: 20070225372Abstract: The present invention provides BRACE inhibitors of Formula (I): methods for their use, and intermediates and methods for their preparation.Type: ApplicationFiled: April 8, 2005Publication date: September 27, 2007Inventors: Ana Bueno Melendo, Shu-Hui Chen, Jon Erickson, Maria Rosario Gonzalez-Garcia, Deqi Guo, Alicia Marcos Lorente, James McCarthy, Timothy Shepherd, Scott Sheehan, Yvonne Yip
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Publication number: 20070213331Abstract: The present invention provides BACE inhibitors of Formula I: methods for their use and preparation, and intermediates for their preparation.Type: ApplicationFiled: April 8, 2005Publication date: September 13, 2007Inventors: Robert Dally, Timothy Shepherd, David Bender, Maria Rojo Garcia
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Publication number: 20070111988Abstract: The present invention relates to a selective estrogen receptor modulators of formula I (I); or a pharmaceutical acid addition salt thereof; and of formula II (II); or a pharmaceutical salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.Type: ApplicationFiled: January 18, 2005Publication date: May 17, 2007Applicant: ELI LILLY AND COMPANYInventors: Robert Dally, Jeffrey Dodge, Conrad Hummel, Scott Jones, Timothy Shepherd, Owen Wallace, Wayne Weber
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Publication number: 20060183736Abstract: The present invention relates to a selective estrogen receptor modulator of formula I or a pharmaceutical acid addition salt thereof; useful, e.g., for treating endometriosis and/or uterine leiomyoma/leiomyomata.Type: ApplicationFiled: July 16, 2003Publication date: August 17, 2006Inventors: Robert Dally, Jeffrey Dodge, Scott Frank, Scott Jones, Timothy Shepherd, Owen Wallace, Kin Fong, Conrad Hummel, George Lewis
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Publication number: 20050272791Abstract: The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis.Type: ApplicationFiled: July 31, 2003Publication date: December 8, 2005Applicant: Eil Lilly and CompanyInventors: Rosanne Bonjouklian, Jose De Diego Gomez, Alfonso De Dios, Chafiq Hamdouchi, Tiecho Li, Beatriz De Uralde Garmendia, Michal Vieth, Jeremy York, Robert Dally, Miriam Del Prado Catalina, Carlos Jaramillo Aguado, Luisa Martin-Cabrejas, Carlos Montero Salgado, Sheila Pleite Selgas, Concepcion Sanchez-Martinez, Timothy Shepherd, James Wikel
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Publication number: 20050024053Abstract: A fluid monitoring arrangement 1 for an engine is operated in accordance with a method whereby nuclear magnetic resonance (NMR) interrogation of the fluid flow 3 it is possible to determine whether appropriate fluids and additives are being utilised as well as whether potential detrimental actions occur such as engine wear and carbonisation through particulate components within the flow 3. Generally, an expected signal response from the fluid flow 3 is determined and the actual signal response compared in a comparator 8 with that expected signal response. Divergence in the actual signal response and in particular with regard to its profile is identified and an indication provided in a display 10 with regard to the potential coolant of such divergence. Normally, a reference library 11 is provided of expected signal responses for comparison in the comparator with the actual signal responses.Type: ApplicationFiled: July 7, 2004Publication date: February 3, 2005Inventors: Ian Care, Timothy Shepherd
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Patent number: 6693199Abstract: A method of making HIV protease inhibitors of general formula (1): These HIV compounds inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other antiviral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.Type: GrantFiled: November 21, 2002Date of Patent: February 17, 2004Assignee: Agouron Pharmaceuticals, Inc.Inventors: Bruce A. Dressman, James E. Fritz, Marlys Hammond, William J. Hornback, Stephen W. Kaldor, Vincent J. Kalish, John E. Munroe, Siegfried Heinz Reich, John H. Tatlock, Timothy A. Shepherd, Michael J. Rodriguez
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Publication number: 20030216569Abstract: A method of making HIV protease inhibitors of general formula (1): 1Type: ApplicationFiled: November 21, 2002Publication date: November 20, 2003Inventors: Bruce A. Dressman, James E. Fritz, Marlys Hammond, William J. Hornback, Stephen W. Kaldor, Vincent J. Kalish, John E. Munroe, Siegfried Heinz Reich, John H. Tatlock, Timothy A. Shepherd, Michael J. Rodriguez
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Patent number: 6525215Abstract: Compounds useful as intermediates in the preparation of HIV protease inhibitors.Type: GrantFiled: June 21, 2001Date of Patent: February 25, 2003Assignee: Agouron Pharmaceuticals, Inc.Inventors: Bruce A. Dressman, James E. Fritz, Marlys Hammond, William J. Hornback, Stephen W. Kaldor, Vincent J. Kalish, John E. Munroe, Siegfried Heinz Reich, John H. Tatlock, Timothy A. Shepherd, Michael J. Rodriguez
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Publication number: 20020077338Abstract: HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other antiviral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.Type: ApplicationFiled: June 21, 2001Publication date: June 20, 2002Inventors: Bruce A. Dressman, James E. Fritz, Marlys Hammond, William J. Hornback, Stephen W. Kaldor, Vincent J. Kalish, John E. Munroe, Siegfried Heinz Reich, John H. Tatlock, Timothy A. Shepherd, Michael J. Rodriguez