Patents by Inventor Timothy Springer

Timothy Springer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11499753
    Abstract: The flameless heater system includes an energy source comprising a diesel engine configured to create volumes of air, a hydraulic system to control engine loading for heat generation and for air moving, and a control system, operatively coupled with the energy source and the hydraulic system to control at least one of a speed of the diesel engine, a loading of the diesel engine, or a fan speed.
    Type: Grant
    Filed: October 22, 2019
    Date of Patent: November 15, 2022
    Assignee: Anderson Industries, LLC
    Inventors: Daniel Ewert, Timothy Springer
  • Publication number: 20220348609
    Abstract: Alpha(v) beta (6) integrin (avb6) binding polypeptides are disclosed herein, and their use in treating and detecting tumors, and their use in treating pulmonary fibrosis.
    Type: Application
    Filed: October 23, 2020
    Publication date: November 3, 2022
    Inventors: Anindya Roy, Lei Shi, Xianchi Dong, Jing Li, Timothy Springer, David Baker
  • Patent number: 11398136
    Abstract: Gaming systems and methods that enables the exchange of monetary currency for a greater amount of virtual currency based on a first exchange rate for use by a player via the gaming system, and the exchange of virtual currency back to monetary currency based on second and third exchange rates, and in certain instances with a virtual currency usage fee. In various embodiments, the first exchange rate, the second exchange rate, the third exchange rate, and/or the virtual currency usage fee may vary based on one or more different factors such as but not limited to casino driven factors.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: July 26, 2022
    Assignee: IGT
    Inventor: Timothy Springer
  • Publication number: 20210264729
    Abstract: Gaming systems and methods that enables the exchange of monetary currency for a greater amount of virtual currency based on a first exchange rate for use by a player via the gaming system, and the exchange of virtual currency back to monetary currency based on second and third exchange rates, and in certain instances with a virtual currency usage fee. In various embodiments, the first exchange rate, the second exchange rate, the third exchange rate, and/or the virtual currency usage fee may vary based on one or more different factors such as but not limited to casino driven factors.
    Type: Application
    Filed: May 10, 2021
    Publication date: August 26, 2021
    Inventor: Timothy Springer
  • Patent number: 11011020
    Abstract: Gaming systems and methods that enables the exchange of monetary currency for a greater amount of virtual currency based on a first exchange rate for use by a player via the gaming system, and the exchange of virtual currency back to monetary currency based on second and third exchange rates, and in certain instances with a virtual currency usage fee. In various embodiments, the first exchange rate, the second exchange rate, the third exchange rate, and/or the virtual currency usage fee may vary based on one or more different factors such as but not limited to casino driven factors.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: May 18, 2021
    Assignee: IGT
    Inventor: Timothy Springer
  • Publication number: 20200394872
    Abstract: Gaming systems and methods that enables the exchange of monetary currency for a greater amount of virtual currency based on a first exchange rate for use by a player via the gaming system, and the exchange of virtual currency back to monetary currency based on second and third exchange rates, and in certain instances with a virtual currency usage fee. In various embodiments, the first exchange rate, the second exchange rate, the third exchange rate, and/or the virtual currency usage fee may vary based on one or more different factors such as but not limited to casino driven factors.
    Type: Application
    Filed: June 17, 2019
    Publication date: December 17, 2020
    Inventor: Timothy Springer
  • Publication number: 20200132338
    Abstract: The flameless heater system includes an energy source comprising a diesel engine configured to create volumes of air, a hydraulic system to control engine loading for heat generation and for air moving, and a control system, operatively coupled with the energy source and the hydraulic system to control at least one of a speed of the diesel engine, a loading of the diesel engine, or a fan speed.
    Type: Application
    Filed: October 22, 2019
    Publication date: April 30, 2020
    Inventors: Daniel Ewert, Timothy Springer
  • Patent number: 8021668
    Abstract: The present invention provides an isolated polypeptide capable of binding to aCAM-1, comprising the integrin (XL I domain or biologically active portion thereof, wherein one or more residues is substituted, wherein the substituted polypeptide binds ICAM-I at a higher affinity than wild type integrin CCL protein. The invention provides a method for inhibiting ICAM-I and a pharmaceutical composition comprising an integrin (XL I domain polypeptide or biologically active portion of the polypeptides. The invention also provides a method of treating or preventing an LFA-I mediated ICAM-1 associated disease such as inflammation, artherosclerosis, allograft rejection, diabetes, T-cell mediated sensitization reaction, psoriasis, HIV infection, or rheumatoid arthritis.
    Type: Grant
    Filed: December 12, 2006
    Date of Patent: September 20, 2011
    Assignee: Immune Disease Institute, Inc.
    Inventors: Moonsoo Jin, Timothy Springer
  • Publication number: 20080311130
    Abstract: The present invention provides an isolated polypeptide capable of binding to aCAM-1, comprising the integrin (XL I domain or biologically active portion thereof, wherein one or more residues is substituted, wherein the substituted polypeptide binds ICAM-I at a higher affinity than wild type integrin CCL protein. The invention provides a method for inhibiting ICAM-I and a pharmaceutical composition comprising an integrin (XL I domain polypeptide or biologically active portion of the polypeptides. The invention also provides a method of treating or preventing an LFA-I mediated ICAM-1 associated disease such as inflammation, artherosclerosis, allograft rejection, diabetes, T-cell mediated sensitization reaction, psoriasis, HIV infection, or rheumatoid arthritis.
    Type: Application
    Filed: December 12, 2006
    Publication date: December 18, 2008
    Applicant: IMMUNE DISEASE INSTITUTE, INC.
    Inventors: Moonsoo Jin, Timothy Springer
  • Publication number: 20050260192
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: November 24, 2005
    Inventors: Timothy Springer, Motomu Shimaoka, Chafen Lu
  • Patent number: 6951927
    Abstract: The invention relates to novel proteins with novel integrin and I domain activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of integrin related disorders. TABLE 1 Computationally designed mutantsa WT ido1q ido1r ido2r jlm2r Backbone Energyb 1ido ?1037 ??1145 ?1138 ?1116 ??678 1jlm ?1059 +82758 ??840 ?1000 ?1086 Position Residues 139 I — — V — 153 M — — A — 156 F L W — — 157 V — — I — 160 V I — — — 199 V I I I — 215 I L L — V 219 V — — — I 223 F — — — L 238 V F F I I 239 V L L L — 240 I L L — — 259 A L L — — 269 I L — — — 271 V F — — — 287 I V V V — 299 V A I I — 308 I V — — — aMutants are named according to the structure that was stabilized (ido or jlm), the solvation potential used (1 or 2) and the definition of core residues (q or r).
    Type: Grant
    Filed: July 9, 2001
    Date of Patent: October 4, 2005
    Assignee: California Institute of Technology
    Inventors: Stephen Mayo, Julia Shifman, Motomu Shimaoka, Timothy Springer
  • Publication number: 20050182244
    Abstract: The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulfide bond in only one protein conformation, and therefore lock the protein in a given conformation. Accordingly, antibody and small molecule therapeutics are selected that are specific for the desired protein conformation. The invention also provides modified integrin I-domain polypeptides that are stabilized in a desired conformation. The invention further provides screening assays and therapeutic methods utilizing the modified integrin I-domains of the invention.
    Type: Application
    Filed: March 15, 2005
    Publication date: August 18, 2005
    Inventors: Timothy Springer, Motomu Shimaoka, Chafen Lu
  • Publication number: 20030054440
    Abstract: The invention relates to novel proteins with novel integrin and I domain activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of integrin related disorders.
    Type: Application
    Filed: July 9, 2001
    Publication date: March 20, 2003
    Inventors: Stephen Mayo, Julia Shifman, Motomu Shimaoka, Timothy Springer
  • Patent number: 5948758
    Abstract: The invention relates to therapeutic methods of using a substantially pure protein comprising the .beta.-subunit of a human glycoprotein involved in cellular adhesion, or a biologically active fragment thereof, or analog thereof. These therapeutic methods are useful for treating auto immune diseases and allograft rejection.
    Type: Grant
    Filed: March 4, 1997
    Date of Patent: September 7, 1999
    Assignee: Dana Faber Cancer Institute Inc.
    Inventors: Timothy Springer, Takashi K. Kishimoto, Thomas M. Roberts
  • Patent number: 5739032
    Abstract: The present invention discloses a cDNA sequence which encodes the beta-subunit of LFA-1. The present invention further discloses fragments of the cDNA sequence which are capable of recognizing a restriction length polymorphism within the LFA-1 sequence.
    Type: Grant
    Filed: April 6, 1994
    Date of Patent: April 14, 1998
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Timothy Springer, Takashi K. Kishimoto, Thomas M. Roberts
  • Patent number: 5190859
    Abstract: A method of purifying LFA-3 using affinity chromatography. Purified LFA-3 is useful for quantitating or separating out CD-2-containing cells.
    Type: Grant
    Filed: October 3, 1989
    Date of Patent: March 2, 1993
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Michael Dustin, Timothy Springer
  • Patent number: 5071964
    Abstract: A micelle of an adhesion protein which naturally includes a phosphatidylinositol lipid anchor, the micelle being capable of binding multivalently to a plurality of target molecules on a cell surface; where the adhesion protein is LFA-3, the LFA-3 micelles can be administered to a patient to inhibit binding of activated T-cells to other cells.
    Type: Grant
    Filed: April 17, 1990
    Date of Patent: December 10, 1991
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Michael Dustin, Timothy Springer