Abstract: The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.

Abstract: A polymeric scaffold useful for conjugating with a protein based recognition-molecule (PBRM) to form a PBRM-polymer-drug conjugate is described herein. The scaffold includes one or more terminal maleimido groups. Also disclosed is a PBRM-polymer-drug conjugate prepared from the scaffold. Compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions are also described.

Abstract: The invention concerns a multilayer biaxially oriented white polyester film (adhesion, absence of chalking, opacity whiteness, reflectance, hydrolysis resistance & light stability) comprising three polyester layers: a core layer and two outer layers and contains TiO2 particles. In this film: at least one layer comprises a PET whose: number average molecular weight is within [18500-40000]; intrinsic viscosity IV is ?0.70 dL/g; and carboxyl group content is ?30 eq/T. Additionally, the core layer comprises TiO2 particles in a range of [0.1-40]% w/w; the intrinsic viscosity IV is between [0.5-0.85] dL/g; a small endothermic peak temperature is between 180-230° C.; and at least one light stabilizer is added in at least one of the outer layers, in a total concentration between [0.1-35]% w/w. The invention also includes the method for manufacturing such film and the laminate which is part of the back sheet of a solar cell.

Abstract: A control unit connected to power supplies and loads transitions between states to connect supplies and loads in various configurations. In a first state, for example, the first supply and first load are connected in series, and the second supply and second load are connected in series. In a second state, the first supply and second load are connected in series, and the second supply and first load are connected in series. The control unit transitions between states via a transition state in which all supplies and loads are connected in parallel, avoiding load power disruptions. First and second power supplies can be rechargeable battery packs, and first and second loads can be any devices drawing or generating power. If one load is a motor and the other a generator, one battery can power the motor and the other battery can be charged using the generator.

Abstract: A product catalog system includes a product catalog having product offers received from various merchants. The product catalog system includes an analysis module that determines, for each merchant that provides product offers, which product offers are for products that are likely to be variants of one another based in part on titles of the products and assigns sets of product offers that are likely to be variants a merchant cluster identifier. The analysis module groups the product offers into product catalog entries based on the particular product that the offers are for. The analysis module determines which products are variants based on associations between the product catalog entries and the merchant cluster identifiers of the product offers included in the product catalog entries.

Abstract: The invention concerns a multilayer biaxially oriented white polyester film (adhesion, absence of chalking, opacity whiteness, reflectance, hydrolysis resistance & light stability) which has three polyester layers: a core layer and two outer layers and contains TiO2 particles. In this film: (i) at least one layer includes a PET whose: number average molecular weight is within [18500-40000]; intrinsic viscosity IV is ?0.70 dL/g; carboxyl group content is ?30 eq/T (ii) the core layer includes TiO2 particles [0.1-40]% w/w; (iii) the intrinsic viscosity IV of the film is between [0.5-0.85] dL/g; (iv) a small endothermic peak temperature is between 180-230° C.; (v) at least one light stabilizer is added in at least one of the outer layers, in a total concentration between [0.1-35]% w/w. The invention also includes the method for manufacturing such film and the laminate which includes the above multilayered film and which is part of the back sheet of a solar cell.

Abstract: A product catalog system includes a product catalog having product offers received from various merchants. The product catalog system includes an analysis module that determines, for each merchant that provides product offers, which product offers are for products that are likely to be variants of one another based in part on titles of the products and assigns sets of product offers that are likely to be variants a merchant cluster identifier. The analysis module groups the product offers into product catalog entries based on the particular product that the offers are for. The analysis module determines which products are variants based on associations between the product catalog entries and the merchant cluster identifiers of the product offers included in the product catalog entries.

Abstract: A data display system including a plurality of data sources; a data transmitter coupled to the data sources and to a transmission network comprising a power line; wherein the data transmitter comprises means for modulating the data as a frequency modulated carrier and means for transmitting the carrier over the power line; and a plurality of gauges each having a display and coupled to the power line, and a data receiver comprising means for demodulating the carrier and means for translating the data to the display. The gauges are coupled to the data transmitter only by the power line, disregarding any ground connections, and the power line provides power to the gauges and the data transmitter.

Abstract: An intrusion detection system (IDS) is capable of identifying the source of traffic, filtering the traffic to classify it as either safe or suspect and then applying sophisticated detection techniques such as stateful pattern recognition, protocol parsing, heuristic detection or anomaly detection either singularly or in combination based on the traffic type. In a network environment, each traffic source is provided with at least one IDS sensor that is dedicated to monitoring a specific type of traffic such as RPC, HTTP, SMTP, DNS, or others. Traffic from each traffic source is filtered to remove known safe traffic to improve efficiency and increase accuracy by keeping each IDS sensor focused on a specific traffic type.

Abstract: The present invention provides tough, high modulus, low density thermoset polyurethane compositions which are useful in general as, for example, cast structural materials and in a preferred embodiment can be cured directly onto an aircraft engine fan blade, thereby providing a lighter blade, without concomitant loss in structural integrity or blade performance due to, for example, resistance to foreign object impacts and fuel efficiency. In a preferred embodiment, the composition is comprised of bis-amine compounds reacted with isocyanate-functional polyether polymers in the presence of hollow polymeric microspheres. The thermoset polymer compositions are formed by casting into a mold which is formed by a cavity within the metallic or composite fan blade or guide vane in the form of a pocket and a removable caul sheet. After the elastomeric polyurethane foam is injected through at least one injector port into the mold, the foam is cured.

Abstract: The present invention provides tough, high modulus, low density thermoset polyurethane compositions which are useful in general as, for example, cast structural materials and in a preferred embodiment can be cured directly onto an aircraft engine fan blade, thereby providing a lighter blade, without concomitant loss in structural integrity or blade performance due to, for example, resistance to foreign object impacts and fuel efficiency. In a preferred embodiment, the composition is comprised of bis-amine compounds reacted with isocyanate-functional polyether polymers in the presence of hollow polymeric microspheres. The thermoset polymer compositions are formed by casting into a mold which is formed by a cavity within the metallic or composite fan blade or guide vane in the form of a pocket and a removable caul sheet. After the elastomeric polyurethane foam is injected through at least one injector port into the mold, the foam is cured.

Abstract: A gas turbine engine rotor disk has a number of annular hubs circumscribed about a centerline and each of the hubs is connected to a disk rim by a web. A plurality of circumferentially spaced apart circular arc dovetail slots are disposed through the rim. Circumferentially extending annular burst slots extend radially through the rim into the dovetail slots between each adjacent pair of the webs. The fan blades have circular arc dovetail roots disposed within the circumferentially spaced apart circular arc dovetail slots. A one piece spinner attached to a forward extension of the disk at a location between a tip and an axially aft spinner end of the spinner. Non-integral platforms circumferentially disposed between the fan blades. A booster spool is connected to the rotor disk by a mounting plate therebetween and the platforms are radially retained to the disk and mounting plates by pins through holes in mounting lugs depending radially inwardly from the platforms.

Abstract: The present invention provides tough, high modulus, low density thermoset polyurethane compositions which are useful in general as, for example, cast structural materials and in a preferred embodiment can be cured directly onto an aircraft engine fan blade, thereby providing a lighter blade, without concomitant loss in structural integrity or blade performance due to, for example, resistance to foreign object impacts and fuel efficiency. In a preferred embodiment, the composition is comprised of bis-amine compounds reacted with isocyanate-functional polyether polymers in the presence of hollow polymeric microspheres. The thermoset polymer compositions are formed by casting into a mold which is formed by a cavity within the metallic or composite fan blade or guide vane in the form of a pocket and a removable caul sheet. After the elastomeric polyurethane foam is injected through at least one injector port into the mold, the foam is cured.

Abstract: A gas turbine engine rotor disk has a number of annular hubs circumscribed about a centerline and each of the hubs is connected to a disk rim by a web. A plurality of circumferentially spaced apart dovetail slots are disposed through the rim, extending circumferentially between disk posts, extending axially from a forward end to an aft end of the rim, and extending radially inwardly from a disk outer surface of the rim. Circumferentially extending annular burst slots extend radially through the rim into the dovetail slots between each adjacent pair of the webs. In the exemplary embodiment of the disk illustrated herein, the dovetail slots are circular arc dovetail slots. An axially forwardly extending overhang is located radially outwardly on each of the disk posts and a chamfer is on a radially outer corner of the each of the disk posts on a portion of the overhangs.

Abstract: A gas turbine engine rotor disk has a number of annular hubs circumscribed about a centerline and each of the hubs is connected to a disk rim by a web. A plurality of circumferentially spaced apart circular arc dovetail slots are disposed through the rim. Circumferentially extending annular burst slots extend radially through the rim into the dovetail slots between each adjacent pair of the webs. The fan blades have circular arc dovetail roots disposed within the circumferentially spaced apart circular arc dovetail slots. A one piece spinner attached to a forward extension of the disk at a location between a tip and an axially aft spinner end of the spinner. Non-integral platforms circumferentially disposed between the fan blades. A booster spool is connected to the rotor disk by a mounting plate therebetween and the platforms are radially retained to the disk and mounting plates by pins through holes in mounting lugs depending radially inwardly from the platforms.

Abstract: An exemplary embodiment of the invention is a spinner for a front end of a fan assembly of a gas turbine engine. The spinner includes a single piece substantially conically shaped hollow body circumscribed about a centerline extending aftwardly from a tip to an axially aft spinner end. A plurality of bolt holes extend axially parallel to the centerline through the hollow body at an axial location between the tip and the aft spinner end. The hollow body may include a forward conical section extending aftwardly from the tip to a transition section, an aft conical section extending aftwardly from the transition section to the aft spinner end, and the bolt holes are axially located in the transition section. An aft spinner flange attached to the axially aft spinner end includes a plurality of flange lightening holes axially disposed through the aft spinner flange and the flange lightening holes.

Abstract: A fan blade includes a metal airfoil having a pocket disposed in a first side thereof, with the pocket including a filler bonded thereto. The pocket includes a plurality of cells separated by corresponding ribs which are submerged in the filler.

Abstract: Disclosed are semicrystalline polyester oriented films having the properties of MD F5.gtoreq.18 daN/mm.sup.2, TD F5.gtoreq.10 daN/mm.sup.2, MDE.gtoreq.800 daN/mm.sup.2, TDE.gtoreq.400 daN/mm.sup.2, MDE+TDE.gtoreq.1200 daN/mm.sup.2, MDS 105.ltoreq.1.5%, MDS 150.ltoreq.5.2%, and TD St/TD F5.ltoreq.2.2. Also disclosed is a process for preparing semicrystalline polyester oriented films wherein an amorphous polyester film is successively subjected to a sequence of drawings comprising a lengthwise drawing in a single stage, a transverse drawing and a lengthwise drawing, wherein the first drawing mD is conducted at a temperature of between Tg +40.degree. C. and Tc -20.degree. C. and with a draw ratio .lambda.mD of between 1.2 and 3.