Abstract: A system and method based on the use of a mobile application running on a handheld mobile device that can be manipulated by a user/patient with the result that the data gathered by the application is communicated via a secure link to a computer service in order for evaluation of the user/patient's neurological and physical functioning for purposes of detecting changes in the progression of certain functions to aid in the diagnosis of certain diseases, such as multiple sclerosis and related neurological diseases.

Abstract: A system and method based on the use of a mobile application running on a handheld mobile device that can be manipulated by a user/patient with the result that the data gathered by the application is communicated via a secure link to a computer service in order for evaluation of the user/patient's neurological and physical functioning for purposes of detecting changes in the progression of certain functions to aid in the diagnosis of certain diseases, such as multiple sclerosis and related neurological diseases.

Abstract: The invention provides epsilon toxin (ETX) produced by Clostridium perfringens type B or type D as a causative toxin for human multiple sclerosis (MS). The invention further identifies ETX binding receptor MAL for ETX mediated cell death and other toxin-logical activities in MS. Methods and compositions to prevent humans from multiple sclerosis (MS) and/or treating MS by directly or indirectly interfering with epsilon toxin (ETX), its binding receptor (e.g., MAL), or ETX-receptor interactions so as to inhibit or suppress downstream ETX mediated receptor signaling activities are provided. Also provided are various methods to detect, diagnose, monitor, assess multiple sclerosis (MS) by determining an expression level of ETX gene or its encoding protein in human patient suspected for and/or at risk for multiple sclerosis (MS).

Abstract: The invention provides epsilon toxin (ETX) produced by Clostridium perfringens type B or type D as a causative toxin for human multiple sclerosis (MS). The invention further identifies ETX binding receptor MAL for ETX mediated cell death and other toxin-logical activities in MS. Methods and compositions to prevent humans from multiple sclerosis (MS) and/or treating MS by directly or indirectly interfering with epsilon toxin (ETX), its binding receptor (e.g., MAL), or ETX-receptor interactions so as to inhibit or suppress downstream ETX mediated receptor signaling activities are provided. Also provided are various methods to detect, diagnose, monitor, assess multiple sclerosis (MS) by determining an expression level of ETX gene or its encoding protein in human patient suspected for and/or at risk for multiple sclerosis (MS).