Patents by Inventor Timothy W. Evans

Timothy W. Evans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purification of somatotropin from transformed microorganisms
    Patent number: 6916914
    Abstract: This invention discloses a commercially advantageous process for extraction and purification of protein from microorganisms. The initial steps of the process are useful for purifying many insoluble proteins while later steps are designed to renature denatured somatotropins produced by transformed microorganisms. The process is especially useful for purifying recombinantly-produced bovine somatotropin.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: July 12, 2005
    Assignee: Pharmacia & Upjohn Co.
    Inventors: Timothy W. Evans, Mark W. Knuth
  • Purification of somatotropin from transformed microorganisms
    Patent number: 6586575
    Abstract: This invention discloses a commercially advantageous process for extraction and purification of protein from microorganisms. The initial steps of the process are useful for purifying many insoluble proteins while later steps are designed to renature denatured somatotropins produced by transformed microorganisms. The process is especially useful for purifying recombinantly-produced bovine somatotropin.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: July 1, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Timothy W. Evans, Mark W. Knuth
  • Microbial .DELTA.1-dehydrogenation process using a scavenger of toxic oxygen
    Patent number: 4749649
    Abstract: A process for converting 1,2-saturated 3-keto steroids to 1,2-dehydro steroids which are useful steroid intermediates. The process involves exposing the substrate to steroid-1-dehydrogenase activity in the presence of an added electron carrier and one or more added scavengers of a toxic oxygen species.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: June 7, 1988
    Assignee: The Upjohn Company
    Inventors: Timothy W. Evans, Leo A. Kominek, Holly J. Wolf, Sheryl L. Henderson
  • Process for converting 1,2-saturated steroids to 1,2-dehydro steroids
    Patent number: 4684610
    Abstract: Disclosed and claimed is an improved microbial bioconversion to produce 1,2-dehydro steroids from their corresponding 1,2-saturated derivatives by use of a water-immiscible solvent comprising an aromatic hydrocarbon in the reaction procedure.
    Type: Grant
    Filed: April 17, 1985
    Date of Patent: August 4, 1987
    Assignee: The Upjohn Company
    Inventor: Timothy W. Evans
  • Process for the recovery of spectinomycin
    Patent number: 4203903
    Abstract: An improved process for recovering the antibiotic spectinomycin from an aqueous concentrate containing the same. This improvement concerns the use of benzoic acid, or a salt thereof, to remove inorganic salts which interfere with the recovery of spectinomycin from an aqueous concentrate.
    Type: Grant
    Filed: May 10, 1979
    Date of Patent: May 20, 1980
    Assignee: The Upjohn Company
    Inventor: Timothy W. Evans
  • Process of purifying cholesterol oxidase
    Patent number: 4043870
    Abstract: This invention relates to a novel process for purifying aqueous solutions which contain cholesterol oxidase. In particular, this invention relates to a process for removing nonionic surfactants from aqueous processing solutions containing cholesterol oxidase by extraction with a water-immiscible solvent.
    Type: Grant
    Filed: May 11, 1976
    Date of Patent: August 23, 1977
    Assignee: The Upjohn Company
    Inventor: Timothy W. Evans