Abstract: A decontamination system for victims of chemical, biological, radiological, or other harmful exposure. The system effectively isolates a contaminated patient during a gross washing process and provides the highest level of protection to unit operators that may be dressed in street clothes. The system comprises an isolation apparatus, a washing chamber, an output enclosure, a method of passing a non-ambulatory patient through the system and a waste collection system. The parts of the system may function together as a single, integral unit for mass decontamination at the site of exposure. Further, the system may be used for non-ambulatory and ambulatory humans and/or animals and possibly equipment and other objects.