Patents by Inventor Timothy Wencewicz

Timothy Wencewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DIHYDROFOLATE SYNTHASE (DHFS) INHIBITING AGENTS AND METHODS OF MAKING AND USING SAME
    Publication number: 20230322667
    Abstract: The present disclosure provides for compositions of, synthetic methods of, and methods for use of dihydrofolate synthase (DHFS) inhibiting agents.
    Type: Application
    Filed: April 7, 2023
    Publication date: October 12, 2023
    Applicant: Washington University
    Inventors: Timothy Wencewicz, Brett Virgin-Downey
  • Chemoenzymatic synthesis of peptide beta-lactones and beta-hydroxy acids
    Patent number: 10655153
    Abstract: Methods of producing peptide beta-lactones and beta-hydroxy acids are disclosed that include contacting a beta-hydroxy-alpha-amino acid, an aryl carrier protein (ObiD), and ATP with a non-ribosomal protein synthetase. A continuous flow reactor is disclosed that includes an elongate conduit with at least one region that includes a first region with a non-ribosomal protein synthetase immobilized to a substrate. The non-ribosomal protein synthetase of the continuous flow reactor is configured to contact a flow of a reaction mixture that includes a beta-hydroxy-alpha-amino acid and an aryl carrier protein. The non-ribosomal protein synthetase is further configured to release a peptide beta-lactone into the flow of the reaction mixture.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: May 19, 2020
    Assignee: Washington University
    Inventors: Timothy A. Wencewicz, Jason E. Schaffer, Margaret R. Reck
  • Inhibition and diagnostics of emerging tetracycline resistance enzymes
    Patent number: 10273468
    Abstract: The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: April 30, 2019
    Assignee: Washington University
    Inventors: Niraj Tolia, Gautam Dantas, Timothy Wencewicz, Jooyoung Park, Andrew Gasparrini, Kevin Forsberg, Joseph Vogel, Margaret Ruth Reck, Chanez Tiffany Symister, Jana L. Markley
  • CHEMOENZYMATIC SYNTHESIS OF PEPTIDE BETA-LACTONES AND BETA-HYDROXY ACIDS
    Publication number: 20180265905
    Abstract: Methods of producing peptide beta-lactones and beta-hydroxy acids are disclosed that include contacting a beta-hydroxy-alpha-amino acid, an aryl carrier protein (ObiD), and ATP with a non-ribosomal protein synthetase. A continuous flow reactor is disclosed that includes an elongate conduit with at least one region that includes a first region with a non-ribosomal protein synthetase immobilized to a substrate. The non-ribosomal protein synthetase of the continuous flow reactor is configured to contact a flow of a reaction mixture that includes a beta-hydroxy-alpha-amino acid and an aryl carrier protein. The non-ribosomal protein synthetase is further configured to release a peptide beta-lactone into the flow of the reaction mixture.
    Type: Application
    Filed: March 14, 2018
    Publication date: September 20, 2018
    Applicant: Washington University
    Inventors: Timothy A. Wencewicz, Jason E. Schaffer, Margaret R. Reck
  • INHIBITION AND DIAGNOSTICS OF EMERGING TETRACYCLINE RESISTANCE ENZYMES
    Publication number: 20170369864
    Abstract: The present disclosure provides compositions and methods for treating bacterial infections in a subject. The methods comprise administering a compound that binds a FAD-dependent flavoenzyme and a tetracycline, analog, derivative, or pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 26, 2017
    Publication date: December 28, 2017
    Applicant: Washington University
    Inventors: Niraj Tolia, Gautam Dantas, Timothy Wencewicz, Jooyoung Park, Andrew Gasparrini, Kevin Forsberg, Joseph Vogel, Margaret Ruth Reck, Chanez Tiffany Symister, Jana L. Markley