Patents by Inventor Timothy Willson

Timothy Willson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Orphan Nuclear Receptor
    Publication number: 20080096239
    Abstract: The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monoxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding such a receptor, to methods of making the receptor and to methods of using the receptor and nucleic acid sequences encoding same. The invention also relates to non-human animals transformed to express the human receptor and to methods of using such animals to screen compounds for drug interactions and toxicities.
    Type: Application
    Filed: June 22, 2007
    Publication date: April 24, 2008
    Applicant: SMITHKLINE BEECHAM CORPORATION
    Inventors: Steven Kliewer, Stacey Jones, Timothy Willson
  • Purine derivatives as liver x receptor agonists
    Publication number: 20060094733
    Abstract: The invention relates to methods for the treatment or prevention of an LXR mediated disease or condition, including cardiovascular disease and atherosclerosis, novel compounds for use in such methods and pharmaceutical compositions comprising compounds for use in such methods.
    Type: Application
    Filed: May 20, 2003
    Publication date: May 4, 2006
    Applicant: Glaxo Group Limited
    Inventors: Sharon Boggs, Jon Loren Collins, Adam Fivush, Eugene Stewart, Timothy Willson
  • Substituted aminopropoxyaryl derivatives useful as agonists for LXR
    Publication number: 20050282908
    Abstract: The invention relates to a compound of formula (I), wherein all variables are as defined herein, and pharmaceutically acceptable salts or solvates thereof. The compounds of formula (I) are useful as LXR agonists.
    Type: Application
    Filed: June 16, 2005
    Publication date: December 22, 2005
    Inventors: Jon Collins, Adam Fivush, Patrick Maloney, Eugene Stewart, Timothy Willson
  • Crystallized hnf4 gamma ligand binding domain polypeptide and screening methods employing same
    Publication number: 20050131209
    Abstract: A solved three-dimensional crystal structure of an HNF4g ligand binding domain polypeptide is disclosed, along with a crystal form of the HNF4g ligand binding domain. Methods of designing modulators of the biological activity of HNF4g, and other HNF4 ligand binding domain polypeptides are also disclosed.
    Type: Application
    Filed: January 31, 2002
    Publication date: June 16, 2005
    Inventors: Roderick Davis, Robert Johnson, Aaren Miller, James Way, Shawn Williams, Timothy Willson, George Wisely, Ann Kontz