Patents by Inventor Timothy Woudenberg
Timothy Woudenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20070128652Abstract: The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel.Type: ApplicationFiled: December 29, 2006Publication date: June 7, 2007Applicant: Applera CorporationInventors: Timothy Woudenberg, Reid Kowallis
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Publication number: 20070111299Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: January 9, 2007Publication date: May 17, 2007Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20070111300Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device includes a substrate which defines a sample-distribution network having (i) a sample inlet, (ii) one or more detection chambers, and (iii) channel means providing a dead-end fluid connection between each of the chambers and the inlet. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: January 9, 2007Publication date: May 17, 2007Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20060286659Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: December 21, 2006Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20060269641Abstract: A thermal cycler for automatic performance of the polymerase chain reaction is provided. The thermal cycler comprises a heater control that provides close temperature control of the reaction.Type: ApplicationFiled: May 12, 2006Publication date: November 30, 2006Applicant: Applera CorporationInventors: John Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20060269934Abstract: Compositions and methods of use are disclosed for clonally amplifying and analyzing one or more polynucleotides.Type: ApplicationFiled: March 16, 2006Publication date: November 30, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Cheryl Heiner, Eric Nordman
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Publication number: 20060210439Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. The device can comprise wells and each well can comprise an analyte-specific reagent effective to react with a selected analyte that may be present in the sample. Also disclosed are methods utilizing the device.Type: ApplicationFiled: May 16, 2006Publication date: September 21, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20060204401Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: May 10, 2006Publication date: September 14, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20060188917Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: April 7, 2006Publication date: August 24, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20060183151Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: April 7, 2006Publication date: August 17, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20060166352Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: February 24, 2006Publication date: July 27, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20060127939Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: January 27, 2006Publication date: June 15, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Raqusa, Emily Winn-Deen
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Publication number: 20060128007Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: February 8, 2006Publication date: June 15, 2006Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20050186684Abstract: A method for making a test device is provided. The method can comprise providing (a) a substrate comprising a plurality of wells, wherein each well comprises at least one dimension no greater than 1 mm; (ii) a robotic dispensing system comprising at least one piezoelectric dispenser; and (iii) a liquid solution comprising at least one analyte-specific reagent. The method further comprises delivering a volume of the liquid solution into at least some of the wells using the at least one piezoelectric dispenser. The volume can be no greater than about 1 microliter. The method can further comprise placing a cover over the wells.Type: ApplicationFiled: April 12, 2005Publication date: August 25, 2005Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Ragusa, Emily Winn-Deen
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Publication number: 20050158781Abstract: The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality of different analytes in a liquid sample. Each chamber may include an analyte-specific reagent effective to react with a selected analyte that may be present in the sample, and detection means for detecting the signal. Also disclosed are methods utilizing the device.Type: ApplicationFiled: January 5, 2005Publication date: July 21, 2005Applicant: Applera CorporationInventors: Timothy Woudenberg, Michael Albin, Reid Kowallis, Yefim Raysberg, Robert Raqusa, Emily Winn-Deen
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Publication number: 20050112634Abstract: Methods for amplifying polynucleotides, e.g., by PCR, in a sample comprising polynucleotide targets present at very low concentration, comprising: (a) applying amplification reactants to the surface of a substrate comprising reaction spots, wherein the reactants comprise the sample and an amplification reagent; (b) forming a sealed reaction chamber, having a volume less than about 120 nanoliters, preferably less than about 20 nanoliters, over each of said reaction spots; and (c) thermal cycling the substrate and reactants. In one embodiment, the forming step comprises loading a sealing fluid, e.g., mineral oil, on the surface so as to cover the reaction spots. The present invention also provides microplates, comprising: (a) a substrate having at least about 10,000 reaction spots, each comprising a primer and a droplet of reagent having a volume less than about 120 nanoliters, preferably less then about 20 nanoliters; and (b) a sealing liquid isolating each of the spots.Type: ApplicationFiled: September 17, 2004Publication date: May 26, 2005Inventors: Timothy Woudenberg, Robert Jones, Kenneth Livak
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Publication number: 20050084957Abstract: A sample tube including a cylindrical part and a conical part is described. The cylindrical part can include, a first wall portion having a first wall portion thickness, a second wall portion having a second wall portion thickness, and a shoulder including a planar first surface and a conically beveled second surface disposed between the first wall portion and the second wall portion. The first wall portion can be disposed closer to the planar first surface than the conically beveled second surface. The conical part can be shaped as a frustrum of a cone having a conical part wall thickness. The frustrum can include a wider-end and a narrower-end. The wider-end of the frustrum can be in contact with the second wall portion of the cylindrical part. At least one of the first wall portion thickness and the second wall portion thickness can be greater than the conical part wall thickness.Type: ApplicationFiled: August 30, 2004Publication date: April 21, 2005Applicant: Applera CorporationInventors: John Atwood, Susan Stone, Judith Atwood, Albert Mossa, Lisa Goven, Fenton Williams, Timothy Woudenberg, Marcel Margulies, Robert Ragusa, Richard Leath, Clive Miles
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Publication number: 20050074774Abstract: The present invention generally relates to the detection of analytes, particularly biomolecules in samples. The invention also relates to compositions, methods, and kits for detecting the presence of analytes, typically in multiplex detection formats. The invention also relates to methods for determining the presence of at least one analyte in a sample, the methods employing employ single molecule detection techniques to individually detect at least one molecular complex or at least part of a molecular complex.Type: ApplicationFiled: August 29, 2003Publication date: April 7, 2005Applicant: Applera CorporationInventors: Timothy Woudenberg, Dar Bahatt, Muhammad Sharaf, Timothy Liu, Serguei Ermakov, Charles Connell, Jens Hyldig-Nielsen
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Publication number: 20050069895Abstract: The teachings herein generally relates to probes comprising fabricated coded molecular tags for detecting analytes. The teachings also relate to compositions, methods, and kits for fabricating coded molecular tags comprising a multiplicity or reporter groups in an ordered pattern.Type: ApplicationFiled: August 29, 2003Publication date: March 31, 2005Applicant: Applera CorporationInventors: Timothy Woudenberg, Dar Bahatt, Muhammad Sharaf, Timothy Liu, Serguei Ermakov, Charles Connell, Jens Hyldig-Nielsen, Benjamin Schroeder, Paolo Vatta
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Publication number: 20050061669Abstract: Bubble-free electrodes, electrochemical cells including bubble-free electrodes, analytical devices, and methods for preparing and using them are provided. The analytical devices each include at least one bubble-free electrode. Analytical devices that include an electrochemical cell and a sample containment device are also provided, wherein the electrochemical cell includes an anodic reservoir, a cathodic reservoir, an electrical connection between the anodic reservoir and the cathodic reservoir, and a first bubble-free electrode disposed within one of the anodic reservoir and the cathodic reservoir. A second electrode is disposed within the other reservoir and a power source is provided having a positive terminal that is normally in electrical contact with the first electrode, and a negative terminal that is normally in electrical contact with the second electrode.Type: ApplicationFiled: November 9, 2004Publication date: March 24, 2005Applicant: Applera CorporationInventors: Timothy Woudenberg, Zbigniew Bryning, Reid Kowallis