Abstract: Systems and methods for enabling cross-tenant access are provided. In particular, a computing device may receive an access request, from a user of a first tenant, requesting access to a resource of a plurality of resources on a shared collaborative channel of a second tenant. The computing device may further evaluate cross-tenant access policies of the first and second tenants to determine that access to the plurality of resources is authorized by the first and second tenants, validate that the user is a member of the shared collaborative channel, and generate a validation token indicating the user is validated to access the plurality of resources. Based on the validation token, the computing device may further validate that the user is in compliance with the cross-tenant access policies for accessing the resource and grant the user a set of permissions to access the resource.

Abstract: The present invention features antisense oligonucleotides (AONs) for the treatment of diseases and disorders associated with the deleterious effects of transposable element insertion (e.g., long interspersed nuclear element-i (LINE-1), Arthrobacter luteus element (Alu), short interspersed nuclear element variable number tandem repeat Arthrobacter luteus element (SINE-VNTR-Alu) or (SVA), or endogenous retrovirus (ERV). In one aspect, the invention provides one or more antisense oligonucleotides complementary to a transposable element present in an intronic sequence within a gene. In another aspect, the invention provides a method for treating a subject having a genetic disorder associated with the insertion of a transposable element, the method involving administering to the subject one or more antisense oligonucleotides of any aspect delineated herein.

Abstract: Systems and methods for enabling cross-tenant access are provided. In particular, a computing device may receive an access request, from a user of a first tenant, requesting access to a resource of a plurality of resources on a shared collaborative channel of a second tenant. The computing device may further evaluate cross-tenant access policies of the first and second tenants to determine that access to the plurality of resources is authorized by the first and second tenants, validate that the user is a member of the shared collaborative channel, and generate a validation token indicating the user is validated to access the plurality of resources. Based on the validation token, the computing device may further validate that the user is in compliance with the cross-tenant access policies for accessing the resource and grant the user a set of permissions to access the resource.

Abstract: Described herein are methods and compositions related to the modulation of progranulin expression or activity in the brain for the treatment of neurodegenerative diseases.

Abstract: Described herein are methods and compositions related to the modulation of progranulin expression or activity in the brain for the treatment of neurodegenerative diseases.

Abstract: Described herein are methods and compositions related to the modulation of progranulin expression or activity in the brain for the treatment of neurodegenerative diseases.

Abstract: A connector having a relatively high terminal density is provide for reducing the requirement of the electric currents in one signal terminal and increase the conducting efficiency. The connector includes plural first conducting components each having a first terminal and extended laterally, plural second conducting components each having at least two second terminals and extended laterally, and an insulating housing having plural slots for mounting the plural first conducting components and the plural second conducting components, wherein each first conducting component and each corresponding second conducting component are mounted in the respective slot, so as to contain a contact pad having plural pins.

Abstract: A heat-dissipating assembly for removing a portion of heat from a heat-generating device includes a fan and a heat sink. The fan has holes. The heat sink has a base in contact with a surface of the heat-generating device, and first fins and second fins extending upwards from the base, wherein the second fins further have projecting plates corresponding to the holes and each of the projecting plates includes a pedestal and a fastening portion, the height of the pedestal being substantially the same as that of the fan, wherein the projecting plates are inserted into the corresponding holes and the fasting portions are bent so as to be in contact with the upper surface of the fan.

Abstract: A fin-shaped heat dissipation apparatus for an electronic device. The fin-shaped heat dissipation apparatus has a thermal conductive plate and a fin-shaped heat sink. The fin-shaped heat sink is in a wave formed including alternative peaks and troughs. Either the troughs or the peaks are coupled to the thermal conductive plate, while the thermal conductive plate is coupled to the electronic device.

Abstract: The present invention discloses a power supply system with modularized and integrated cable interface configuration for providing power from an external power source to a plurality of subsystems in a personal computer. The power supply system includes a power cable for connecting the power supply system to the external power source. The power supply system further includes an output (O/P) cable having a first end and second end, the O/P cable including a plurality of cable groups wherein each of the cable groups including a subsystem plug module on the first end for connecting to a corresponding PC subsystems. The power supply system further includes an integrated PC receptive module for providing an interface with the O/P cable. The O/P cable further including an integrated O/P cable plug module on the second end for plugging the O/P cable into the integrated receptive module, wherein the integrated O/P plug module being in electric connection to each of the cable groups.

Abstract: .alpha.-Aminoalkyl-3-(1,2-dihydroxyethyl)-4-hydroxy-benzyl alcohols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are disclosed.

Abstract: Novel 7-oxocephalosporins and a process for preparing them are disclosed. These compounds are useful intermediates in the preparation of other cephalosporins which have antibacterial activity.

Abstract: 7-Mandelamido-3-(1-oxidopyridylthiomethyl)-3-cephem-4-carboxylic acid and substituted derivatives which have antibacterial activity are disclosed.

Abstract: .alpha.-Aminomethyl-5-hydroxy-2-pyridinemethanols having .beta.-adrenergic stimulant activity, particularly as selective bronchodilators, are prepared generally from a 2-pyridine-carboxaldehyde by reaction with an appropriate isocyanide, via an amide intermediate followed by reduction to an amine and finally catalytic hydrogenation to remove benzyl protective groups.