Abstract: Embodiments of the present disclosure provide a surgical robot system may include an end-effector element configured for controlled movement and positioning and tracking of surgical instruments and objects relative to an image of a patient's anatomical structure. In some embodiments the end-effector may be tracked by surgical robot system and displayed to a user. In some embodiments the end-effector element may be configured to restrict the movement of an instrument assembly in a guide tube. In some embodiments, the end-effector may contain structures to allow for magnetic coupling to a robot arm and/or wireless powering of the end-effector element. In some embodiments, tracking of a target anatomical structure and objects, both in a navigation space and an image space, may be provided by a dynamic reference base located at a position away from the target anatomical structure.

Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A surgical instrument, has an end effector that includes an ultrasonic blade, and a clamp arm that moves relative to the ultrasonic blade from an opened position toward an intermediate position and a closed position. The clamp arm is offset from the ultrasonic blade to define a predetermined gap in the intermediate position between the opened position and the closed position. A clamp arm actuator connects to the clamp arm and moves from an opened configuration to a closed configuration to direct the clamp arm from the opened position toward the intermediate position and the closed position. A spacer connects with the clamp arm to inhibit movement of the clamp arm from the intermediate position toward the closed position for maintaining the predetermined gap between the clamp arm and the ultrasonic blade.

Abstract: The present invention relates to Tetracyclic Heterocycle Compounds of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein R1 is as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Heterocycle Compound, and methods of using the Tetracyclic Heterocycle Compounds for treating or preventing HIV infection in a subject.

Abstract: Provided herein are systems, devices, and methods for performing a medical procedure on a patient. The system comprises an ablation catheter comprising a shaft, at least one therapeutic element positioned on the shaft, and one or more tissue-contact sensing components configured to provide a contact signal related to the level of contact between the at least one therapeutic element and tissue. The system further comprises: an energy delivery unit configured to deliver ablative energy to the at least one therapeutic element to create a lesion in target tissue, and to provide an energy delivery data; a force module configured to receive the contact signal and provide contact data; and a processing unit configured to determine an ablation index based on both the energy delivery data and the contact data. The ablation index can represent the status of the lesion being created.

Abstract: Electric vehicle supply equipment includes a processor having a first file including software code for detecting whether a pilot connection exists with a vehicle interface of a vehicle and a second file partitioned from the first file including software code for requesting the vehicle interface to toggle a pilot switch a predetermined number of cycles.

Abstract: A product container made of a certain plastic material, and the coupling of multiple such product containers together are disclosed herein. Each of the product containers includes either a solid or a solid/liquid combination product therein, which impacts the process of coupling the product containers.

Abstract: Techniques for determining a vehicle trajectory that causes a vehicle to navigate in an environment relative to one or more objects are described herein. For example, the techniques may include a computing device determining a decision tree having nodes to represent different object intents and/or nodes to represent vehicle actions at a future time. A tree search algorithm can search the decision tree to evaluate potential interactions between the vehicle and the one or more objects over a time period, and output a vehicle trajectory for the vehicle. The vehicle trajectory can be sent to a vehicle computing device for consideration during vehicle planning, which may include simulation.

Abstract: To satisfy the need for refitting the lighting of a vehicle without the need to modify the controlling system of the vehicle, the present invention proposes a lighting system which comprises an electrical element (110), configured to consume the received power and incapable of emitting light; a light source (130); and a controller (120), configured to receive a first signal indicating the working status of the electrical element (110) and control the light source (130) generating a first light and a second light, respectively, based on the first signal. By utilizing the signal indicating the working status of the electrical element (110), which element is used to replace another automotive lamp, the controller can control the light source (130) to mimic said another automotive lamp while performing its original function.

Abstract: To satisfy the need for refitting the lighting of a vehicle without the need to modify the controlling system of the vehicle, the present invention proposes a lighting system which comprises an electrical element (110), configured to consume the received power and incapable of emitting light; a light source (130); and a controller (120), configured to receive a first signal indicating the working status of the electrical element (110) and control the light source (130) generating a first light and a second light, respectively, based on the first signal. By utilizing the signal indicating the working status of the electrical element (110), which element is used to replace another automotive lamp, the controller can control the light source (130) to mimic said another automotive lamp while performing its original function.