Patents by Inventor Timur Yarovinsky

Timur Yarovinsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods of use of oncolytic virus like vesicles
    Patent number: 12577585
    Abstract: The present invention relates to high-titer hybrid vims vectors which produce virus-like vesicle (VLVs) and compositions and methods thereof for targeting a malignancy or infectious disease. VLVs are a capsid-free, self-replicating artificial virus platform carrying positive-strand capped and polyadenylated RNA encoding an in vitro evolved Semliki Forest vims (SFV) RNA-dependent RNA replicase and the vesicular stomatitis virus (VSV) glycoprotein. The VLVs of the present invention and pharmaceutical compositions thereof encode for polynucleotide and/or polypeptide therapeutic agents useful in methods for the treatment, prophylaxis, and prevention of malignancies and infectious diseases.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: March 17, 2026
    Assignee: Carogen Corporation
    Inventors: Bijan Almassian, Valerian Nakaar, Xianyong Ma, Bhaskara Reddy Madina, Kepeng Wang, Timur Yarovinsky
  • MICRORNA BLOCKADE FOR THE TREATMENT OF DISEASE
    Publication number: 20240182900
    Abstract: In various aspects and embodiments the invention provides compositions and methods useful in the treatment of disease. In one aspect the invention provides a composition comprising a polynucleotide comprising one or more of SEQ ID NOS: 1-41 and at least one modification selected from the group consisting of locked nucleic acid, bridged nucleic acid, phosphorothioate nucleic acid, and peptide nucleic acid.
    Type: Application
    Filed: November 5, 2020
    Publication date: June 6, 2024
    Inventors: Jeffrey BENDER, Vinod RAMGOLAM, Timur YAROVINSKY
  • Blockade of miR466l-3p binding to IL-17A mRNA with site-specific target site blocker prevents neuro-inflammatory-mediated disease
    Publication number: 20230302037
    Abstract: In various aspects and embodiments the invention provides compositions and methods useful in the treatment of inflammatory disease, in particular, multiple sclerosis.
    Type: Application
    Filed: June 6, 2023
    Publication date: September 28, 2023
    Inventors: Jeffrey Bender, Vinod Ramgolam, Timur Yarovinsky
  • Blockade of miR4661-3p binding to IL-17A mRNA with site-specific target site blocker prevents neuro-inflammatory-mediated disease
    Patent number: 11717530
    Abstract: In various aspects and embodiments the invention provides compositions and methods useful in the treatment of inflammatory disease, in particular, multiple sclerosis.
    Type: Grant
    Filed: May 7, 2019
    Date of Patent: August 8, 2023
    Assignee: YALE UNIVERSITY
    Inventors: Jeffrey Bender, Vinod Ramgolam, Timur Yarovinsky
  • COMPOSITIONS AND METHODS OF USE OF ONCOLYTIC VIRUS LIKE VESICLES
    Publication number: 20230063041
    Abstract: The present invention relates to high-titer hybrid vims vectors which produce virus-like vesicle (VLVs) and compositions and methods thereof for targeting a malignancy or infectious disease. VLVs are a capsid-free, self-replicating artificial virus platform carrying positive-strand capped and polyadenylated RNA encoding an in vitro evolved Semliki Forest vims (SFV) RNA-dependent RNA replicase and the vesicular stomatitis virus (VSV) glycoprotein. The VLVs of the present invention and pharmaceutical compositions thereof encode for polynucleotide and/or polypeptide therapeutic agents useful in methods for the treatment, prophylaxis, and prevention of malignancies and infectious diseases.
    Type: Application
    Filed: January 8, 2021
    Publication date: March 2, 2023
    Applicant: Carogen Corporation
    Inventors: Bijan Almassian, Valerian Nakaar, Xianyong Ma, Bhaskara Reddy Madina, Kepeng Wang, Timur Yarovinsky
  • Blockade of miR466l-3p binding to IL-17A mRNA with site-specific target site blocker prevents neuro-inflammatory-mediated disease
    Publication number: 20210069233
    Abstract: In various aspects and embodiments the invention provides compositions and methods useful in the treatment of inflammatory disease, in particular, multiple sclerosis.
    Type: Application
    Filed: May 7, 2019
    Publication date: March 11, 2021
    Inventors: Jeffrey Bender, Vinod Ramgolam, Timur Yarovinsky
  • Topoisomerase activated oligonucleotide adaptors and uses therefor
    Publication number: 20020068290
    Abstract: The invention provides methods and compositions for the rapid joining of a target nucleic acid sequence with a topoisomerase activated adaptor sequence that provides a specific function to the target.
    Type: Application
    Filed: May 31, 2001
    Publication date: June 6, 2002
    Inventor: Timur Yarovinsky